Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.

Autor: Sonia Davila, Martin L Hibberd, Ranjeeta Hari Dass, Hazel E E Wong, Edhyana Sahiratmadja, Carine Bonnard, Bachti Alisjahbana, Jeffrey S Szeszko, Yanina Balabanova, Francis Drobniewski, Reinout van Crevel, Esther van de Vosse, Sergey Nejentsev, Tom H M Ottenhoff, Mark Seielstad

Publikováno v: PLoS Genetics, Vol 4, Iss 10, p e1000218 (2008)

Despite high rates of exposure, only 5-10% of people infected with Mycobacterium tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for genetic variation in the human immune response to this infection. Here, we

Externí odkaz: https://doaj.org/article/92c7c158cba54fe682ce14d2f76b2fb0

Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing

Autor: John A. Todd, Sarah Nutland, Rebecca C.J. Twells, Jeffrey S. Szeszko, Jason D. Cooper, Helen Stevens, Joanna M. M. Howson, Neil Walker

Publikováno v: Diabetes. 55:559-562

Recently, the interleukin-18 cytokine gene (IL18) was reported to be associated with type 1 diabetes. In the present report, we calculated that the reported genotypes of the two 5′ region/promoter single nucleotide polymorphisms (SNPs), −607 (C�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec8a2043e668ad3fe5327e81c63c1b3
https://doi.org/10.2337/diabetes.55.02.06.db05-0826

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis

Autor: Edhyana Sahiratmadja, Esther van de Vosse, Francis Drobniewski, Jeffrey S. Szeszko, Sergey Nejentsev, Mark Seielstad, Yanina Balabanova, Sonia Davila, Bachti Alisjahbana, Reinout van Crevel, Martin L. Hibberd, Hazel E. E. Wong, Tom H. M. Ottenhoff, Carine Bonnard, Ranjeeta Hari Dass

Publikováno v: PLoS Genetics, Vol 4, Iss 10, p e1000218 (2008)
PLoS genetics, vol 4, iss 10
PLoS Genetics
Plos Genetics, 4, e1000218-e1000218
Plos Genetics, 4, 10, pp. e1000218-e1000218

Despite high rates of exposure, only 5–10% of people infected with Mycobacterium tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for genetic variation in the human immune response to this infection. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52f506d5c00a063da3e7a5dae15dfb6
http://europepmc.org/articles/PMC2568981?pdf=render