Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Jeffrey S Mogil"'
Publikováno v:
eLife, Vol 11 (2022)
The mechanisms underlying the transition from acute to chronic pain are unclear but may involve the persistence or strengthening of pain memories acquired in part through associative learning. Contextual cues, which comprise the environment in which
Externí odkaz:
https://doaj.org/article/c75f363cd9e94cedab80ee5127831313
Autor:
Arkady Khoutorsky, Robert P Bonin, Robert E Sorge, Christos G Gkogkas, Sophie Anne Pawlowski, Seyed Mehdi Jafarnejad, Mark H Pitcher, Tommy Alain, Jimena Perez-Sanchez, Eric W Salter, Loren Martin, Alfredo Ribeiro-da-Silva, Yves De Koninck, Fernando Cervero, Jeffrey S Mogil, Nahum Sonenberg
Publikováno v:
eLife, Vol 4 (2015)
Activation of the mechanistic/mammalian target of rapamycin (mTOR) kinase in models of acute and chronic pain is strongly implicated in mediating enhanced translation and hyperalgesia. However, the molecular mechanisms by which mTOR regulates nocicep
Externí odkaz:
https://doaj.org/article/1646d0777a1b4f18ab3e65cd60d5602c
Publikováno v:
PLoS Biology, Vol 12, Iss 5, p e1001863 (2014)
Preclinical researchers confront two overarching agendas related to drug development: selecting interventions amid a vast field of candidates, and producing rigorous evidence of clinical promise for a small number of interventions. We suggest that ea
Externí odkaz:
https://doaj.org/article/835d26b2650a48708202d848d2b3fd7d
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/fea0c270a4484fbf902c26c68f1e6905
Autor:
Patricia Soriano Roque, Carolina Thörn Perez, Mehdi Hooshmandi, Calvin Wong, Mohammad Javad Eslamizade, Shilan Heshmati, Nicole Brown, Vijendra Sharma, Kevin C. Lister, Vanessa Magalie Goyon, Laura Neagu-Lund, Cathy Shen, Nicolas Daccache, Hiroaki Sato, Tamaki Sato, Jeffrey S. Mogil, Karim Nader, Christos G. Gkogkas, Mihaela D. Iordanova, Masha Prager-Khoutorsky, Heidi M. McBride, Jean-Claude Lacaille, Linda Wykes, Thomas Schricker, Arkady Khoutorsky
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly
Externí odkaz:
https://doaj.org/article/a714889051cb4d529be111104342892a
Autor:
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thörn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Séguéla, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the intrinsic properties of the nociceptive endings, leads to nociceptive hyperexcitability and thus
Externí odkaz:
https://doaj.org/article/486d93f8afa440fda061b38bd05ee999
Publikováno v:
PAIN Reports, Vol 5, Iss 3, p e824 (2020)
Abstract. Introduction:. Increasing attention is being paid to the effects of organismic factors like age on pain sensitivity. However, very little data exist on this topic using modern algesiometric assays and measures in laboratory rodents. Objecti
Externí odkaz:
https://doaj.org/article/553d7fadfbad4b5399a7a7362c1377a2
Autor:
Sonali Uttam, Calvin Wong, Inês S. Amorim, Seyed Mehdi Jafarnejad, Shannon N. Tansley, Jieyi Yang, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Christos G. Gkogkas, Arkady Khoutorsky
Publikováno v:
Neurobiology of Pain, Vol 4, Iss , Pp 35-44 (2018)
Acute pain serves as a protective mechanism, guiding the organism away from actual or potential tissue injury. In contrast, chronic pain is a debilitating condition without any obvious physiological function. The transition to, and the maintenance of
Externí odkaz:
https://doaj.org/article/f350ac7b5d1c408188a59b41101b6490
Autor:
Wataru, Nemoto, Dalia, Kozak, Susana G, Sotocinal, Shannon, Tansley, Kirsty, Bannister, Jeffrey S, Mogil
Publikováno v:
Pain. 164:1096-1105
Descending control of nociception (DCN; also known as conditioned pain modulation [CPM], the behavioral correlate of diffuse noxious inhibitory controls) is the phenomenon whereby pain inhibits pain in another part of the body and is the subject of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7e1f95c7105dc11623765133456b75
https://doi.org/10.1097/j.pain.0000000000002806
https://doi.org/10.1097/j.pain.0000000000002806
Autor:
Marc Parisien, Samar Khoury, Anne-Julie Chabot-Doré, Susana G. Sotocinal, Gary D. Slade, Shad B. Smith, Roger B. Fillingim, Richard Ohrbach, Joel D. Greenspan, William Maixner, Jeffrey S. Mogil, Inna Belfer, Luda Diatchenko
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1940-1952 (2017)
Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQ
Externí odkaz:
https://doaj.org/article/3a6588954ecc4835a5e89cb2f02df82b