Výsledky vyhledávání - "Jeffrey S Martini"

Akademický článek

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.

Autor: Jessica I Gold, Jeffrey S Martini, Jonathan Hullmann, Erhe Gao, J Kurt Chuprun, Linda Lee, Douglas G Tilley, Joseph E Rabinowitz, Julie Bossuyt, Donald M Bers, Walter J Koch

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e57324 (2013)

G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte g

Externí odkaz: https://doaj.org/article/f933052fcc7e42b0bf320c5f5af94e73

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Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress

Autor: Brent R. DeGeorge, Jeffrey S. Martini, Stephen Soltys, Erhe Gao, Matthieu Boucher, Philip Raake, J. Kurt Chuprun, Andrea D. Eckhart, David M. Harris, Walter J. Koch, Gilbert W. Kim, Leif Erik Vinge

Publikováno v: Circulation. 117:1378-1387

Background— A salient characteristic of dysfunctional myocardium progressing to heart failure is an upregulation of the adenylyl cyclase inhibitory guanine nucleotide (G) protein α subunit, Gα i2 . It has not been determined conclusively whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3cce019b6c4db0779f77865e22c5a6
https://doi.org/10.1161/circulationaha.107.752618

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Regulated Overexpression of the A 1 -Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function

Autor: Joseph R. Libonati, Jeffrey S. Martini, Ling L. Lee, Jeffrey Robbins, Timothy M. Palmer, Jin Zhang, Steven R. Houser, Atsushi Sanbe, Julie C. Good, Jarkko Piuhola, Hajime Funakoshi, Xiongwen Chen, Tung O. Chan, Arthur M. Feldman, David E. Herrmann, Scott M. MacDonnell, Walter J. Koch

Publikováno v: Circulation. 114:2240-2250

Background— Both the A 1 - and A 3 -adenosine receptors (ARs) have been implicated in mediating the cardioprotective effects of adenosine. Paradoxically, overexpression of both A 1 -AR and A 3 -AR is associated with changes in the cardiac phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219e99640bfc6690329b62383414f13e
https://doi.org/10.1161/circulationaha.106.620211

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Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

Autor: Jonathan Hullmann, Douglas G. Tilley, Joseph E. Rabinowitz, Jeffrey S. Martini, Erhe Gao, Linda L. Lee, Walter J. Koch, J. Kurt Chuprun, Jessica I. Gold, Donald M. Bers, Julie Bossuyt

Publikováno v: PLoS ONE
PloS one, vol 8, iss 3
PLoS ONE, Vol 8, Iss 3, p e57324 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041658f11ca255c00c9e2480a0820e95
http://europepmc.org/articles/PMC3589474

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Abstract P195: Nuclear Translocation of GRK5 Following Hypertrophic Stimuli Is a Calmodulin-Dependent Process

Autor: Jessica I Gold, Jeffrey S Martini, J Kurt Chuprun, Walter J Koch

Publikováno v: Circulation Research. 109

Maladaptive ventricular hypertrophy often precedes the pathological endpoint of Heart Failure (HF). G protein Coupled Receptors (GPCRs), such as the β-adrenergic receptor, play a crucial role in the development of cardiac hypertrophy. GPCR Kinase 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0ea047e4f2e1b18a71cb621b9a06e1f
https://doi.org/10.1161/res.109.suppl_1.ap195

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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

Autor: Jeffrey S, Martini, Philip, Raake, Leif E, Vinge, Brent R, DeGeorge, Brent, DeGeorge, J Kurt, Chuprun, David M, Harris, Erhe, Gao, Andrea D, Eckhart, Julie A, Pitcher, Walter J, Koch

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 105(34)

G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs important for myocardial regulation, and both have been shown to be up-regulated in the dysfunc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da06a2b23fd0779468f7ad13f8f80dd
https://pubmed.ncbi.nlm.nih.gov/18711143

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A GRK5 Polymorphism that Inhibits β-Adrenergic Receptor Signaling is Protective in Heart Failure

Autor: Faisal M. Syed, Li Sparks, Abhinav Diwan, Rohan R. Parekh, Stephen B. Liggett, Jeffrey S. Martini, Reagan Kelly, Walter J. Koch, Gerald W. Dorn, Sharon Cresci, John A. Spertus, Harvey S. Hahn, Scot J. Matkovich, Sharon L.R. Kardia

EVALUATION OF: Liggett SB, Cresci S, Kelly RJ et al.: A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat. Med. 14, 510-517 (2008). beta-Adrenoceptor blockade therapy was developed for the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a93afb96167e51c477dd81b02797f0
https://europepmc.org/articles/PMC2596476/

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Abstract 1057: Specific Targeting of Gi Signaling in Normal and Dysfunctional Myocardium

Autor: Andrea D. Eckhart, Brent R. DeGeorge, Philip Raake, Leif Erik Vinge, Jeffrey S. Martini, J K Chuprun, Erhe Gao, Walter J. Koch, Matthieu Boucher, Stephen Soltys, David M. Harris

Publikováno v: Circulation. 116

Evidence has accumulated to suggest that cardiomyocyte apoptosis contributes significantly to the progression of heart failure. A salient characteristic of the failing heart is an upregulation of the adenylyl cyclase inhibitory G protein alpha subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::981a6ffe7613190d6609e373a2cd347e
https://doi.org/10.1161/circ.116.suppl_16.ii_211-b

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Cardiac adenoviral S100A1 gene delivery rescues failing myocardium

Autor: Walter J. Koch, Sven T. Pleger, Melanie Boerries, Paul M.L. Janssen, Andrea D. Eckhart, Dieter Weichenhan, Beatrix Heidt, Mirko Völkers, Jeffrey S. Martini, Eva Löffler, Hugo A. Katus, Andrew Remppis, Matthew L. Williams, Patrick Most

Publikováno v: The Journal of clinical investigation. 114(11)

Cardiac-restricted overexpression of the Ca 2+ -binding protein S100A1 has been shown to lead to increased myocardial contractile performance in vitro and in vivo. Since decreased cardiac expression of S100A1 is a characteristic of heart failure, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cd5f909456a476437c62139a4a0570
https://pubmed.ncbi.nlm.nih.gov/15578088

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