Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

Autor: Hae J Park, Mark A Gregory, Vadym Zaberezhnyy, Andrew Goodspeed, Craig T Jordan, Jeffrey S Kieft, James DeGregori

Publikováno v: eLife, Vol 11 (2022)

While leukemic cells are susceptible to various therapeutic insults, residence in the bone marrow microenvironment typically confers protection from a wide range of drugs. Thus, understanding the unique molecular changes elicited by the marrow is of

Externí odkaz: https://doaj.org/article/ea84268fcc014d5baa026f0532c4b188

A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

Autor: Marisa D Ruehle, Haibo Zhang, Ryan M Sheridan, Somdeb Mitra, Yuanwei Chen, Ruben L Gonzalez Jr, Barry S Cooperman, Jeffrey S Kieft

Publikováno v: eLife, Vol 4 (2015)

Internal ribosome entry sites (IRESs) are powerful model systems to understand how the translation machinery can be manipulated by structured RNAs and for exploring inherent features of ribosome function. The intergenic region (IGR) IRESs from the Di

Externí odkaz: https://doaj.org/article/427c93c8058e4b5fb4ed901849befe4e

The 5' leader of the mRNA encoding the mouse neurotrophin receptor TrkB contains two internal ribosomal entry sites that are differentially regulated.

Autor: Stephanie L Timmerman, Jennifer S Pfingsten, Jeffrey S Kieft, Les A Krushel

Publikováno v: PLoS ONE, Vol 3, Iss 9, p e3242 (2007)

A single internal ribosomal entry site (IRES) in conjunction with IRES transactivating factors (ITAFs) is sufficient to recruit the translational machinery to a eukaryotic mRNA independent of the cap structure. However, we demonstrate that the mouse

Externí odkaz: https://doaj.org/article/3cc17d664c6c472ba033c889a0858f29

Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions

Autor: Lewis Rolband, Damian Beasock, Yang Wang, Yao-Gen Shu, Jonathan D. Dinman, Tamar Schlick, Yaoqi Zhou, Jeffrey S. Kieft, Shi-Jie Chen, Giovanni Bussi, Abdelghani Oukhaled, Xingfa Gao, Petr Šulc, Daniel Binzel, Abhjeet S. Bhullar, Chenxi Liang, Peixuan Guo, Kirill A. Afonin

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, 2022, 20, pp.6120-6137. ⟨10.1016/j.csbj.2022.11.007⟩

The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2bc08700d9fe6521988ef0b53597e3
https://doi.org/10.1016/j.csbj.2022.11.007

Supplementary Tables 1 - 4 from Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization

Autor: Dan Theodorescu, Jeffrey S. Kieft, Xuejiao Wang, Marta Sanchez-Carbayo, Yuanbin Ru, Hong Wang

PDF file - 136K, Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization Table S1. Clinicopathologic characteristics of bladder patient samples in microarray datasets Table S2. Clinicopatholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a496fcc938abf3198cdcad91a11101
https://doi.org/10.1158/1078-0432.22451577.v1