Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jeffrey S Han"'
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006837 (2017)
Long interspersed nuclear element-1s (LINE-1s, or L1s) are an active family of retrotransposable elements that continue to mutate mammalian genomes. Despite the large contribution of L1 to mammalian genome evolution, we do not know where active L1 pa
Externí odkaz:
https://doaj.org/article/631a2af8159e41a194e366bd6981120f
Autor:
Sandra R Richardson, Dorothy Chan, Patricia Gerdes, Jeffrey S Han, Jef D Boeke, Geoffrey J Faulkner
The retrotransposon Long Interspersed Element 1 (L1) contains adenosine rich ORFs, a characteristic that limits its expression in mammalian cells. A previously developed synthetic mouse L1 (smL1) with ORF adenosine content decreased from 40% to 26% s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb605877b546189caeecb4cef4bb6de
https://doi.org/10.1101/2022.08.29.505632
https://doi.org/10.1101/2022.08.29.505632
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 6, p e1006837 (2017)
PLoS Genetics, Vol 13, Iss 6, p e1006837 (2017)
Long interspersed nuclear element-1s (LINE-1s, or L1s) are an active family of retrotransposable elements that continue to mutate mammalian genomes. Despite the large contribution of L1 to mammalian genome evolution, we do not know where active L1 pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dfa06559404607ab4b6a43caf4d465
https://pubmed.ncbi.nlm.nih.gov/28586350
https://pubmed.ncbi.nlm.nih.gov/28586350
Autor:
Jan-Hendrik Trösemeier, Axel V. Horn, Gerald G. Schumann, Robert A. Jabulowsky, Carsten Münk, Johannes Löwer, Kay-Martin Hanschmann, Henning Hofmann, André Berger, Sabine Klawitter, Anja Bock, Ananda Ayyappan Jaguva Vasudevan, Egbert Flory, Jeffrey S. Han, Roswitha Löwer, Ulrike Held
Publikováno v:
Nucleic Acids Research
LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive proliferation resulted in the generation of ≈ 34% of the human genome. They have been shown to be a cause of single-gene diseases. Moreover, L1-encoded endonuclease can elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6f44f06f408885c41f27329d8d305c
http://europepmc.org/articles/PMC3874205
http://europepmc.org/articles/PMC3874205
Autor:
Axel V, Horn, Jeffrey S, Han
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1400
Long interspersed nuclear element (LINE) retrotransposons make up significant parts of mammalian genomes. They alter host genomes by direct mutagenesis through integration of new transposon copies, by mobilizing non-autonomous transposons, by changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f40ef8a97aca2324e44f06a60cea37f
https://pubmed.ncbi.nlm.nih.gov/26895051
https://pubmed.ncbi.nlm.nih.gov/26895051
Autor:
Axel V. Horn, Jeffrey S. Han
Publikováno v:
Methods in Molecular Biology ISBN: 9781493933709
Long interspersed nuclear element (LINE) retrotransposons make up significant parts of mammalian genomes. They alter host genomes by direct mutagenesis through integration of new transposon copies, by mobilizing non-autonomous transposons, by changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e96a566f4d99109ec46ce2511862bbae
https://doi.org/10.1007/978-1-4939-3372-3_9
https://doi.org/10.1007/978-1-4939-3372-3_9
Autor:
Sarah J. Wheelan, Jef D. Boeke, Candice E. Coombes, Jeffrey S. Han, Ping Ye, Wenfeng An, Christina Triplett, Edward S. Davis
Publikováno v:
Proceedings of the National Academy of Sciences. 103:18662-18667
Long interspersed element type 1 (L1) retrotransposons are ubiquitous mammalian mobile elements and potential tools for in vivo mutagenesis; however, native L1 elements are relatively inactive in mice when introduced as transgenes. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731527e6686472fd05662419aca55d87
https://doi.org/10.1073/pnas.0605300103
https://doi.org/10.1073/pnas.0605300103
Publikováno v:
Genome Research. 15:1073-1078
The L1 retrotransposon is the most highly successful autonomous retrotransposon in mammals. This prolific genome parasite may on occasion benefit its host through genome rearrangements or adjustments of host gene expression. In examining possible eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa62e079b4d01fca5025cc168468ad6
https://doi.org/10.1101/gr.3688905
https://doi.org/10.1101/gr.3688905
Autor:
Jeffrey S. Han, Jef D. Boeke
Publikováno v:
BioEssays. 27:775-784
LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074c1cab764dee523e283de59ee85a4c
https://doi.org/10.1002/bies.20257
https://doi.org/10.1002/bies.20257