Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jeffrey S Denny"'
Publikováno v:
Applied In Vitro Toxicology. 9:13-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe9a0420a9dc7ffc9948331204e12752
https://doi.org/10.1089/aivt.2022.0013
https://doi.org/10.1089/aivt.2022.0013
Autor:
Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz
Publikováno v:
Toxicol Sci
Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb6524a19ef791df91df42dd10d0e95
https://doi.org/10.1093/toxsci/kfac014
https://doi.org/10.1093/toxsci/kfac014
Autor:
Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung
Publikováno v:
Toxicol Sci
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f2fa073d9a14784133cb3ac98477b
https://doi.org/10.1093/toxsci/kfaa036
https://doi.org/10.1093/toxsci/kfaa036
Autor:
Joseph J. Korte, Sigmund J. Degitz, Phillip C. Hartig, Jessica P Christensen, Jennifer H Olker, Paige M Kent, Carsten Knutsen, Mary C. Cardon, Michael W. Hornung, Jeffrey S. Denny
Publikováno v:
Toxicological Sciences. 168:430-442
Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8efb5fab58a9168c1f0124bb1a0ce01
https://doi.org/10.1093/toxsci/kfy302
https://doi.org/10.1093/toxsci/kfy302
Autor:
Sigmund J. Degitz, Jennifer H Olker, Phillip C. Hartig, Mary C. Cardon, Jonathan T. Haselman, Joseph J. Korte, Jeffrey S. Denny, Michael W. Hornung
Publikováno v:
Toxicol In Vitro
The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption. This highly conserved enzyme plays an essential role in maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e32d38a329beb29a438f2710808fe4
https://pubmed.ncbi.nlm.nih.gov/33352258
https://pubmed.ncbi.nlm.nih.gov/33352258
Publikováno v:
Environ Toxicol Chem
Feminization of male fish and the role of endocrine-active chemicals in this phenomenon has been an area of intense study for many years. Estrone (E1), a natural steroid, is found in aquatic environments sometimes at high concentrations relative to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dffcd7c70e78ba810d891f612704c28
https://pubmed.ncbi.nlm.nih.gov/33448467
https://pubmed.ncbi.nlm.nih.gov/33448467
Autor:
Joseph J. Korte, Sally A. Mayasich, Phillip C. Hartig, Michael W. Hornung, Jennifer H Olker, Joseph O’Flanagan, Sigmund J. Degitz, Jeffrey S. Denny, Philip DeGoey
Publikováno v:
Toxicol In Vitro
Deiodinase enzymes are critical for tissue-specific and temporal control of activation or inactivation of thyroid hormones during vertebrate development, including amphibian metamorphosis. We previously screened ToxCast chemicals for inhibitory activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba790009f960d28137c71f33bef83c0
https://doi.org/10.1016/j.tiv.2021.105141
https://doi.org/10.1016/j.tiv.2021.105141
Autor:
Jose, Serrano, Mark A, Tapper, Richard C, Kolanczyk, Barbara R, Sheedy, Tylor, Lahren, Dean E, Hammermeister, Jeffrey S, Denny, Michael W, Hornung, Alena, Kubátová, Patricia A, Kosian, Jessica, Voelker, Patricia K, Schmieder
Publikováno v:
Xenobiotica
1. Cyclic phenones are chemicals of interest to the USEPA and international community due to their potential for endocrine disrupting activity. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e53dc9b3fec4de446856b1e69f946dd1
https://pubmed.ncbi.nlm.nih.gov/30888238
https://pubmed.ncbi.nlm.nih.gov/30888238
Autor:
Michael W. Hornung, Jessica Voelker, Tylor J. Lahren, Patricia K. Schmieder, Dean E. Hammermeister, Patricia A. Kosian, Mark A. Tapper, Jose Serrano, Alena Kubátová, Barbara R. Sheedy, Richard C. Kolanczyk, Jeffrey S. Denny
1. Cyclic phenones are chemicals of interest to the USEPA due to their potential for endocrine disruption to aquatic and terrestrial species. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b2b217c66f4c2a80cf270577040aaf
Autor:
Barbara R. Sheedy, Richard C. Kolanczyk, Jeffrey S. Denny, Mark A. Tapper, Patricia K. Schmieder
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 207
A representative group of multicyclic aromatic hydrocarbons (MAHC) which can be further classified as bridged-ring (bridged-MAHC) or fused-ring (fused-MAHC) were examined for their ability to interact with the estrogen receptor of rainbow trout (rtER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a4434eb3981b149376fa2c14d3a652
https://pubmed.ncbi.nlm.nih.gov/30513420
https://pubmed.ncbi.nlm.nih.gov/30513420