Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Jeffrey S, Mogil"'
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/fea0c270a4484fbf902c26c68f1e6905
Autor:
Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown, Lisbet Haglund, Jean Ouellet, Carlo Santaguida, Alfredo Ribeiro-da-Silva, Soroush Tahmasebi, Masha Prager-Khoutorsky, Jiannis Ragoussis, Ji Zhang, Michael W. Salter, Luda Diatchenko, Luke M. Healy, Jeffrey S. Mogil, Arkady Khoutorsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microglia subpopulations may differentially contribute to pain. Here, the authors show that peripheral nerve injury induces time- and sex-specific transcriptional changes in mouse spinal cord microglia subpopulations and that ApoE is linked to neurop
Externí odkaz:
https://doaj.org/article/da0c9468505d43fa969f7922829123de
Autor:
Patricia Soriano Roque, Carolina Thörn Perez, Mehdi Hooshmandi, Calvin Wong, Mohammad Javad Eslamizade, Shilan Heshmati, Nicole Brown, Vijendra Sharma, Kevin C. Lister, Vanessa Magalie Goyon, Laura Neagu-Lund, Cathy Shen, Nicolas Daccache, Hiroaki Sato, Tamaki Sato, Jeffrey S. Mogil, Karim Nader, Christos G. Gkogkas, Mihaela D. Iordanova, Masha Prager-Khoutorsky, Heidi M. McBride, Jean-Claude Lacaille, Linda Wykes, Thomas Schricker, Arkady Khoutorsky
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly
Externí odkaz:
https://doaj.org/article/a714889051cb4d529be111104342892a
Autor:
Jeffrey S. Mogil
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Pain needs to be measured in order to be studied and managed. Pain measurement strategies in both humans and non-human animals have varied widely over the years and continue to evolve. This review describes the historical development of human and ani
Externí odkaz:
https://doaj.org/article/3b98a0939c764251894ebfc17c3683af
Autor:
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thörn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Séguéla, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the intrinsic properties of the nociceptive endings, leads to nociceptive hyperexcitability and thus
Externí odkaz:
https://doaj.org/article/486d93f8afa440fda061b38bd05ee999
Autor:
Arjun Muralidharan, Susana G. Sotocinal, Noosha Yousefpour, Nur Akkurt, Lucas V. Lima, Shannon Tansley, Marc Parisien, Chengyang Wang, Jean-Sebastien Austin, Boram Ham, Gabrielle M.G.S. Dutra, Philippe Rousseau, Sioui Maldonado-Bouchard, Teleri Clark, Sarah F. Rosen, Mariam R. Majeed, Olivia Silva, Rachel Nejade, Xinyu Li, Stephania Donayre Pimentel, Christopher S. Nielsen, G. Gregory Neely, Chantal Autexier, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescenc
Externí odkaz:
https://doaj.org/article/2360ec59506d468494cb5246d1be651d
Publikováno v:
eLife, Vol 11 (2022)
The mechanisms underlying the transition from acute to chronic pain are unclear but may involve the persistence or strengthening of pain memories acquired in part through associative learning. Contextual cues, which comprise the environment in which
Externí odkaz:
https://doaj.org/article/c75f363cd9e94cedab80ee5127831313
Autor:
Carolina B. Meloto, Pablo Ingelmo, Eduardo Vega Perez, Rebecca Pitt, Víctor Hugo González Cárdenas, Nada Mohamed, Susana G. Sotocinal, Valerie Bourassa, Lucas Vasconcelos Lima, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Luda Diatchenko
Publikováno v:
PAIN Reports, Vol 6, Iss 2, p e902 (2021)
Abstract. Introduction:. Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain. Objective:. We aimed to
Externí odkaz:
https://doaj.org/article/edb5ce97c3bc46509848427c225c9079
Publikováno v:
PAIN Reports, Vol 5, Iss 3, p e824 (2020)
Abstract. Introduction:. Increasing attention is being paid to the effects of organismic factors like age on pain sensitivity. However, very little data exist on this topic using modern algesiometric assays and measures in laboratory rodents. Objecti
Externí odkaz:
https://doaj.org/article/553d7fadfbad4b5399a7a7362c1377a2
Publikováno v:
Neurobiology of Pain, Vol 4, Iss , Pp 20-26 (2018)
Chronic pain is a pathological condition characterized by long-lasting pain after damaged tissue has healed. Chronic pain can be caused and maintained by changes in various components of the pain pathway, including sensory neurons, spinal cord and hi
Externí odkaz:
https://doaj.org/article/cd7e66d75a754382974b8617414917ed