Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jeffrey S, Humphrey"'
Autor:
Mary D. Ruppe, Xiaoping Zhang, Erik A. Imel, Thomas J. Weber, Mark A. Klausner, Takahiro Ito, Maria Vergeire, Jeffrey S. Humphrey, Francis H. Glorieux, Anthony A. Portale, Karl Insogna, Munro Peacock, Thomas O. Carpenter
Publikováno v:
Bone Reports, Vol 5, Iss , Pp 158-162 (2016)
X-linked hypophosphatemia (XLH) is characterized by lower extremity deformities that lead to bone and/or joint pain that result from decreased renal tubular reabsorption leading to hypophosphatemia caused by elevated levels of fibroblast growth facto
Externí odkaz:
https://doaj.org/article/089ee6dd0b454d568f66892c9fe0c52e
Autor:
Jing Wang, Oksana Zavidij, Srdan Verstovsek, Horatiu Olteanu, Dong Chen, Patrick Trojer, Patricia J. Keller, Claire N. Harrison, Moshe Talpaz, Katarina Luptakova, Gozde Colak, April Chiu, Mohamed E. Salama, Jike Cui, Curtis A. Hanson, Raajit Rampai, John Mascarenhas, Alessandro M. Vannucchi, Ruben A. Mesa, Zehua Chen, Stephen T. Oh, Jennifer A. Mertz, Jeffrey S. Humphrey
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S363-S364
Context: Pelabresib (CPI-0610) is a potent, selective BET bromodomain inhibitor under investigation in the ongoing Phase 2 MANIFEST trial, given as monotherapy to ruxolitinib (rux)-intolerant/refractory myelofibrosis (MF) pts in arm 1, as an “add-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f39ebb3d50c702106655f1aaeb06049b
https://doi.org/10.1016/s2152-2650(21)01835-8
https://doi.org/10.1016/s2152-2650(21)01835-8
Autor:
Gozde Colak, Patrick Trojer, Srdan Verstovsek, Jeffrey S. Humphrey, John Mascarenhas, Jing Wang, Katarina Luptakova, Suresh Bobba, Claire N. Harrison, James Shao
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S363
Context: CPI-0610 is a unique, first-in-class, oral, small-molecule inhibitor of BET proteins, designed to promote disease-modifying activity through selective gene regulation of key oncogenic, fibrotic, and inflammatory factors with potential to tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d6b4d3b00d0d1b2d7af11d01559f258
https://doi.org/10.1016/s2152-2650(21)01834-6
https://doi.org/10.1016/s2152-2650(21)01834-6
Autor:
Gozde Colak, Patricia J. Keller, Srdan Verstovsek, Jing Wang, John Mascarenhas, Jike Cui, Adam J. Mead, Rosana D Meyer, Jennifer A. Mertz, Katarina Luptakova, Oksana Zavidij, Ruben A. Mesa, Patrick Trojer, Jeffrey S. Humphrey, Mohamed E. Salama, Jean-Jacques Kiladjian, Vikas Gupta, James Shao, Claire N. Harrison, Adrian M. Senderowicz, Moshe Talpaz
Publikováno v:
Blood. 136:37-38
Myelofibrosis (MF) is characterized by progressive bone marrow (BM) fibrosis resulting from aberrant megakaryopoeisis and expression of pro-inflammatory cytokines. These two processes, heavily influenced by bromodomain and extraterminal domain (BET)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3337361f6300b521874cae336501ca36
https://doi.org/10.1182/blood-2020-138752
https://doi.org/10.1182/blood-2020-138752
Autor:
John Mascarenhas, Claire Harrison, Katarina Luptakova, Jessica Christo, Jing Wang, Jennifer A Mertz, Gozde Colak, James Shao, Suresh Bobba, Patrick Trojer, Adrian Senderowicz, Jeffrey S Humphrey, Srdan Verstovsek
Publikováno v:
Blood. 136:43-43
The bromodomain and extraterminal domain (BET) family of proteins bind to chromatin to regulate the transcription of target genes involved in multiple pro-fibrotic pathways and is a novel therapeutic target for reducing fibrosis in myelofibrosis (MF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e017125d522ed7bd355ff46d27f3684
https://doi.org/10.1182/blood-2020-140901
https://doi.org/10.1182/blood-2020-140901
Autor:
Youn H Kim, Martine Bagot, Lauren Pinter-Brown, Alain H Rook, Pierluigi Porcu, Steven M Horwitz, Sean Whittaker, Yoshiki Tokura, Maarten Vermeer, Pier Luigi Zinzani, Lubomir Sokol, Stephen Morris, Ellen J Kim, Pablo L Ortiz-Romero, Herbert Eradat, Julia Scarisbrick, Athanasios Tsianakas, Craig Elmets, Stephane Dalle, David C Fisher, Ahmad Halwani, Brian Poligone, John Greer, Maria Teresa Fierro, Amit Khot, Alison J Moskowitz, Amy Musiek, Andrei Shustov, Barbara Pro, Larisa J Geskin, Karen Dwyer, Junji Moriya, Mollie Leoni, Jeffrey S Humphrey, Stacie Hudgens, Dmitri O Grebennik, Kensei Tobinai, Madeleine Duvic, Sunil Abhyankar, Oleg Akilov, Onder Alpdogan, Marie Beylot-Barry, Erin Boh, Dolores Caballero, Richard Cowan, Brigitte Dreno, Reinhard Dummer, Timothy Fenske, Francine Foss, Noriko Fukuhara, Pratyush Giri, Koji Habe, Toshihisa Hamada, Kiyohiko Hatake, Shinsuke Iida, Osamu Ishikawa, Lars Iversen, Eiji Kiyohara, Hiroshi Koga, Neil Korman, Bryone Jean Kuss, Zanetta Lamar, Frederick Lansigan, Mary Jo Lechowicz, Adam Lerner, Nina Magnolo, Lawrence Mark, Tomomitsu Miyagaki, Javier Munoz, Jan Peter Nicolay, Kaoru Nishiwaki, Hiroyuki Okamoto, Mikio Ohtsuka, Theresa Pacheco, Christiane Querfeld, Ronald Peter Rapini, Shigetoshi Sano, Maiko Tanaka, Michael D. Tharp, Jiro Uehara, Hidefumi Wada, Jillian Wells, Ryan A. Wilcox, Basem William, Kentaro Yonekura
Cutaneous T-cell lymphomas are rare non-Hodgkin lymphomas with substantial morbidity and mortality in advanced disease stages. We compared the efficacy of mogamulizumab, a novel monoclonal antibody directed against C-C chemokine receptor 4, with vori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8475d7d251c9235227444c08d963e299
http://hdl.handle.net/11585/674871
http://hdl.handle.net/11585/674871
Autor:
Kathleen M. Williams, Jeffrey S. Humphrey, Naiyer A. Rizvi, Delina A. Conway, Diana J. Daly, Elizabeth Ness, Michael D. Johnson, Daryl Sonnichsen, John Marshall, Elora Gupta, Herbert Hurwitz
Publikováno v:
Clinical Cancer Research. 10:1963-1970
Purpose: BMS-275291 is a novel broad-spectrum inhibitor of matrix metalloproteinase (MMPs) rationally designed to spare a class of closely related metalloproteinases known as sheddases. Inadvertent sheddase inhibition is hypothesized to play a role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9ff00364fcf404b6976b529af9acef
https://doi.org/10.1158/1078-0432.ccr-1183-02
https://doi.org/10.1158/1078-0432.ccr-1183-02
Autor:
Catherine Stolle, Gladys Glenn, Berton Zbar, Jeffrey S. Humphrey, Peter Choyke, McClellan Walther, Svetlanna Pack, Kathy Hurley, Carolyn Andrey, Richard Klausner, W. Marston Linehan
Publikováno v:
Human Mutation. 12:417-423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eb09ed9452768aedf1306f5cdbe4500
https://doi.org/10.1002/(sici)1098-1004(1998)12:6<417::aid-humu8>3.3.co
https://doi.org/10.1002/(sici)1098-1004(1998)12:6<417::aid-humu8>3.3.co
Autor:
McClellan M. Walther, Berton Zbar, Carolyn Andrey, Richard D. Klausner, Catherine A. Stolle, W. Marston Linehan, Jeffrey S. Humphrey, Peter L. Choyke, Svetlanna Pack, Gladys Glenn, Kathy Hurley
Publikováno v:
Human Mutation. 12:417-423
von Hippel-Lindau disease (VHL) is an inherited neoplastic disorder characterized by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland, pancreas, kidney, and epididymis. The VHL tumor suppressor gene was identified i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98cecbbea4e23e35f4de7b7c3225eb69
https://doi.org/10.1002/(sici)1098-1004(1998)12:6<417::aid-humu8>3.0.co
https://doi.org/10.1002/(sici)1098-1004(1998)12:6<417::aid-humu8>3.0.co
Autor:
W. M. Linehan, Jeffrey S. Humphrey, James R. Gnarra, De Chen, Richard D. Klausner, Sang Hyeon Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1770-1775
The product of the von Hippel-Lindau (VHL) tumor suppressor gene, the gene inactivated in VHL disease and in sporadic clear-cell renal carcinomas, has recently been shown to have as a functional target the transcription elongation complex, elongin (a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4eb40abd991d3815fb6a8b8402bf91
https://doi.org/10.1073/pnas.93.5.1770
https://doi.org/10.1073/pnas.93.5.1770