Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jeffrey S, Davies"'
Autor:
Romana Stark, Harry Dempsey, Elizabeth Kleeman, Martina Sassi, Sherri Osborne-Lawrence, Sepideh Sheybani-Deloui, Helen J. Rushby, Christen K. Mirth, Karl Austin-Muttitt, Jonathan Mullins, Jeffrey M. Zigman, Jeffrey S. Davies, Zane B. Andrews
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102025- (2024)
Objective: Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increas
Externí odkaz:
https://doaj.org/article/891d3f35c960479eb772808cf89ddfc5
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101896- (2022)
Summary: We describe a modified BaseScope™ Assay protocol (ACDBio) for RNA in situ hybridization on fixed-frozen human brain tissue. The original protocol caused tissue detachment due to harsh tissue pre-treatment. We therefore optimized it to impr
Externí odkaz:
https://doaj.org/article/156ef02bc0f045ef8a98e6ab9bd81268
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Acyl-ghrelin (AG) is an orexigenic hormone that has a unique octanoyl modification on its third serine residue. It is often referred to as the “hunger hormone” due to its involvement in stimulating food intake and regulating energy homeostasis. T
Externí odkaz:
https://doaj.org/article/02ab1a4215a046db9ac13ff5f0982039
Autor:
Amanda K.E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V. Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Mequinion, Romana Stark, Alex Reichenbach, Sarah H. Lockie, Mario Siervo, Owain Howell, Alwena H. Morgan, Timothy Wells, Zane B. Andrews, David J. Burn, Jeffrey S. Davies
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 7, Pp 100120- (2020)
Summary: Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plastic
Externí odkaz:
https://doaj.org/article/bbc0f91e9dda486a9282f158d171396c
Publikováno v:
Cells, Vol 11, Iss 5, p 765 (2022)
Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulat
Externí odkaz:
https://doaj.org/article/78d8a2a7c2e94b5fa184db8b0e07967a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12346 (2021)
Cell therapy is a promising treatment for Parkinson’s disease (PD), however clinical trials to date have shown relatively low survival and significant patient-to-patient variability. Glucagon Like Peptide-1 receptor (GLP-1R) agonists have potential
Externí odkaz:
https://doaj.org/article/7737bd875e064af7a8c6239e9244d68f
Autor:
Daniel, Rees, Amy L, Beynon, Mariah J, Lelos, Gaynor A, Smith, Luke D, Roberts, Lyndsey, Phelps, Stephen B, Dunnett, Alwena H, Morgan, Rowan M, Brown, Timothy, Wells, Jeffrey S, Davies
Publikováno v:
Cellular and molecular neurobiology.
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson's disease (PD). However, the potential protective effect of acyl-ghrelin on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80c6d669b430079c54c9da5588e12d64
https://pubmed.ncbi.nlm.nih.gov/36107359
https://pubmed.ncbi.nlm.nih.gov/36107359
Autor:
Ann J. Johnston, Jing-Qiong Kang, Wangzhen Shen, William O. Pickrell, Thomas D. Cushion, Jeffrey S. Davies, Kristin Baer, Jonathan G.L. Mullins, Carrie L. Hammond, Seo-Kyung Chung, Rhys H. Thomas, Cathy White, Phil E.M. Smith, Robert L. Macdonald, Mark I. Rees
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 131-141 (2014)
Genetic mutations in voltage-gated and ligand-gated ion channel genes have been identified in a small number of Mendelian families with genetic generalised epilepsies (GGEs). They are commonly associated with febrile seizures (FS), childhood absence
Externí odkaz:
https://doaj.org/article/dc9b7994a81047c3aaaafe890e39676e
Autor:
Jacqueline A Bayliss, Moyra B Lemus, Vanessa V Santos, Minh Deo, Jeffrey S Davies, Bruce E Kemp, John D Elsworth, Zane B Andrews
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159381 (2016)
Metformin is a widely prescribed drug used to treat type-2 diabetes, although recent studies show it has wide ranging effects to treat other diseases. Animal and retrospective human studies indicate that Metformin treatment is neuroprotective in Park
Externí odkaz:
https://doaj.org/article/b85dfa8a090c4b9bbecfce5a0ac911cc
Autor:
Jeffrey S, Davies
Publikováno v:
Vitamins and hormones. 118
The stomach hormone, ghrelin, which is released during food restriction, provides a link between circulating energy state and adaptive brain function. The maintenance of such homeostatic systems is essential for an organism to survive and thrive, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d40782399838df018a302cd2849d6c37
https://pubmed.ncbi.nlm.nih.gov/35180932
https://pubmed.ncbi.nlm.nih.gov/35180932