Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jeffrey Rubens"'
Autor:
Elizabeth Alva, Jeffrey Rubens, Susan Chi, Tom Rosenberg, Alyssa Reddy, Eric H. Raabe, Ashley Margol
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 37, Iss , Pp 100880- (2023)
Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable,
Externí odkaz:
https://doaj.org/article/5c241990d0c5472da5a1d04fc2396d73
Abstract 1141: The CoREST complex as a novel target to disrupt AT/RT’s abnormal epigenetic landscape
Autor:
Anupa Geethadevi, Marianne Collard, Nikhil Vaidya, Tyler Findlay, Kristen Malebranche, Charles Eberhart, Eric Raabe, Philip Cole, Rhoda Alani, Jeffrey Rubens
Publikováno v:
Cancer Research. 83:1141-1141
Atypical teratoid/rhabdoid tumors (AT/RT) are deadly infantile brain tumors. Their aggressive phenotype results from a single recurring biallelic loss-of-function mutation in genes encoding components of the SWI/SNF chromatin-remodeling complex - SMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff891f3e30fdef4d9ceccbb31954f66
https://doi.org/10.1158/1538-7445.am2023-1141
https://doi.org/10.1158/1538-7445.am2023-1141
Publikováno v:
Cancer Research. 83:4990-4990
Diffuse midline glioma (DMG) is an aggressive pediatric glioma with no curative treatment options. Mutation in MAPK pathway is common in many DMG tumors, however, has not been largely explored before. E6201 is a dual inhibitor of ACVR1 and MEK 1/2. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33a4f88bd8fbecf7f74ad3e83f35ee1
https://doi.org/10.1158/1538-7445.am2023-4990
https://doi.org/10.1158/1538-7445.am2023-4990
Publikováno v:
Cancer Research. 83:6720-6720
H3K27-altered diffuse midline glioma (DMG) and atypical teratoid/rhabdoid tumor (AT/RT) are aggressive pediatric brain tumors with dismal outcomes. DMG and AT/RT have increased baseline activation of the integrated stress response (ISR), an evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe5d60ad83cde285d6479de060fc494
https://doi.org/10.1158/1538-7445.am2023-6720
https://doi.org/10.1158/1538-7445.am2023-6720
Autor:
Fausto J. Rodriguez, Jeff S. Mumm, Eric H. Raabe, Liqun Jiang, Jeffrey Rubens, Ming Yuan, Liam Chen, Jennifer Bynum, Eric M. Jackson, Linda M.S. Resar, Charles G. Eberhart, David T. White, Mari L. Groves, Alan R. Cohen, Eli E. Bar
Publikováno v:
Neuro Oncol
Background The conditional reprogramming cell culture method was developed to facilitate growth of senescence-prone normal and neoplastic epithelial cells, and involves co-culture with irradiated fibroblasts and the addition of a small molecule Rho k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e366efad616fafb640a237b0033b3ba6
https://doi.org/10.1093/neuonc/noaa263
https://doi.org/10.1093/neuonc/noaa263
Autor:
Eric H. Raabe, Harpreet Kaur, Shubin Shahab, Charles G. Eberhart, Heather Sweeney, Jeffrey Rubens
Publikováno v:
J Neuropathol Exp Neurol
Atypical teratoid/rhabdoid (AT/RT) tumors are the most common malignant brain tumor of infancy and have a poor prognosis. We have previously identified very high expression of LIN28A and/or LIN28B in AT/RT tumors and showed that AT/RT have correspond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4b458e758faf9ff4187b36b4d8d8a8
https://doi.org/10.1093/jnen/nlaa042
https://doi.org/10.1093/jnen/nlaa042
Autor:
Jeffrey Rubens, David J. Clark, Lijun Chen, Antje Arnold, Micah J. Maxwell, Hui Zhang, Eric H. Raabe, Tung-Shing M. Lih, Michael Schnaubelt, Heather Sweeney, Charles G. Eberhart
Publikováno v:
Molecular & Cellular Proteomics : MCP
The mitogen-activated protein kinase pathway is one of the most frequently altered pathways in cancer. It is involved in the control of cell proliferation, invasion, and metabolism, and can cause resistance to therapy. A number of aggressive malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad6edd54a95268217095d4ba24909d
http://europepmc.org/articles/PMC8363840
http://europepmc.org/articles/PMC8363840
Autor:
Allison Hanaford, Charles G. Eberhart, Antoinette Price, Harpreet Kaur, Brad Poore, Sariah Allen, Brent A. Orr, Barbara S. Slusher, Jesse Alt, Eric H. Raabe, Jeffrey Rubens, Sabrina Wang
Publikováno v:
Clinical Cancer Research. 25:5925-5936
Purpose: Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive infantile brain tumors with poor survival. Recent advancements have highlighted significant molecular heterogeneity in AT/RT with an aggressive subgroup featuring overexpression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9c252945b289071ac3de9ede97e86e
https://doi.org/10.1158/1078-0432.ccr-19-0189
https://doi.org/10.1158/1078-0432.ccr-19-0189
Publikováno v:
Cancer Research. 82:5226-5226
Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive pediatric brain tumors and the most common malignant brain tumors of infancy. The four-year event-free survival rate is only 37%. For patients with relapsed AT/RT, there are limited treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e5949dc5ac2159eb3e9686cb9d38b1
https://doi.org/10.1158/1538-7445.am2022-5226
https://doi.org/10.1158/1538-7445.am2022-5226
Publikováno v:
Cancer Research. 82:5225-5225
Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy with a four-year event-free survival of 37%. Previously, we have identified high activation of both mTORC1 and mTORC2 through immunohistochemistry of 18 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0442b383b7ae39e5afdd12821615ddfd
https://doi.org/10.1158/1538-7445.am2022-5225
https://doi.org/10.1158/1538-7445.am2022-5225