Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Jeffrey Raizer"'
Autor:
David Mills, Hui Gan, Jeffrey Raizer, Patrick Yung Wen, Warren Mason, John DeGroot, Valerie Donnet, Mona El-Hashimy, Mark Rosenthal, Paul M Clement, Mario Campone, Miguel J Gil-Gil, Olivier Chinot, Ahmed Idbaih, Estela Pineda
Publikováno v:
ESMO Open, Vol 5, Iss 4 (2020)
Background Glioblastoma relapse is associated with activation of phosphatidylinositol 3-kinase (PI3K) signalling pathway. In preclinical studies, the pan-PI3K inhibitor buparlisib showed antitumour activity in glioma models.Methods This was a two-par
Externí odkaz:
https://doaj.org/article/9958bcd5cebc4f3d938a04ffd0410a75
Autor:
Andrey Ugolkov, Wenan Qiang, Gennadiy Bondarenko, Daniel Procissi, Irina Gaisina, C. David James, James Chandler, Alan Kozikowski, Hendra Gunosewoyo, Thomas O'Halloran, Jeffrey Raizer, Andrew P. Mazar
Publikováno v:
Translational Oncology, Vol 10, Iss 4, Pp 669-678 (2017)
Resistance to chemotherapy remains a major challenge in the treatment of human glioblastoma (GBM). Glycogen synthase kinase-3β (GSK-3β), a positive regulator of NF-κB–mediated survival and chemoresistance of cancer cells, has been identified as
Externí odkaz:
https://doaj.org/article/f432510ec6364bdcb9e59663f8b8df25
Publikováno v:
F1000Research, Vol 7 (2018)
Meningiomas are the most common adult primary intracranial tumor. Despite their higher incidence, there have not—until recently—been as many advances in understanding and managing meningiomas. Thus far, two broad classes of meningiomas have emerg
Externí odkaz:
https://doaj.org/article/322ad8ab50814ee1be5ad7e69a6ed72c
Autor:
Kohei Shitara, Akihito Kawazoe, Akihiro Hirakawa, Yuka Nakanishi, Satomi Furuki, Musashi Fukuda, Yoko Ueno, Jeffrey Raizer, Ahsan Arozullah
Publikováno v:
Cancer Science. 114:1606-1615
Zolbetuximab is a chimeric monoclonal antibody that targets claudin-18.2, a candidate biomarker in patients with advanced gastric/gastroesophageal cancer. This nonrandomized phase 1 study (NCT03528629) enrolled previously treated Japanese patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6d6daf6b9a3d3ccaeaec0dc35ebacb
https://doi.org/10.1111/cas.15684
https://doi.org/10.1111/cas.15684
Autor:
Leonidas C. Platanias, Michael E. Berens, Jeffrey Raizer, Priya Kumthekar, Kristiina Vuori, Andrew P. Mazar, Craig Horbinski, Ichiro Nakano, C. David James, Shi-Yuan Cheng, Stewart Goldman, Jessica Clymer, Kristen Alley, Elspeth M. Beauchamp, Barbara Kroczynska, Seungchan Kim, Sen Peng, Darren Finlay, Harshil D. Dhruv, Frank Eckerdt, Jonathan B. Bell
These figures show the PN and MES specific drugs identified by the follow-up cell viability screen. Also shown are the enrichment of translation gene sets in MES GSCs. Relates to Figure 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7cdc3e51447c8e7eb1cf3f1f7a66b4
https://doi.org/10.1158/1541-7786.22511688
https://doi.org/10.1158/1541-7786.22511688
Autor:
Leonidas C. Platanias, Michael E. Berens, Jeffrey Raizer, Priya Kumthekar, Kristiina Vuori, Andrew P. Mazar, Craig Horbinski, Ichiro Nakano, C. David James, Shi-Yuan Cheng, Stewart Goldman, Jessica Clymer, Kristen Alley, Elspeth M. Beauchamp, Barbara Kroczynska, Seungchan Kim, Sen Peng, Darren Finlay, Harshil D. Dhruv, Frank Eckerdt, Jonathan B. Bell
This table shows the initial cell viability screen in GBM cells. Relates to Figure 1C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d096560775a9273eb70101b961c7b0
https://doi.org/10.1158/1541-7786.22511679
https://doi.org/10.1158/1541-7786.22511679
Autor:
Leonidas C. Platanias, Michael E. Berens, Jeffrey Raizer, Priya Kumthekar, Kristiina Vuori, Andrew P. Mazar, Craig Horbinski, Ichiro Nakano, C. David James, Shi-Yuan Cheng, Stewart Goldman, Jessica Clymer, Kristen Alley, Elspeth M. Beauchamp, Barbara Kroczynska, Seungchan Kim, Sen Peng, Darren Finlay, Harshil D. Dhruv, Frank Eckerdt, Jonathan B. Bell
Mesenchymal (MES) and proneural (PN) are two distinct glioma stem cell (GSC) populations that drive therapeutic resistance in glioblastoma (GBM). We screened a panel of 650 small molecules against patient-derived GBM cells to discover compounds targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6fc82afde93a5072bdab903c04a4669
https://doi.org/10.1158/1541-7786.c.6540009.v1
https://doi.org/10.1158/1541-7786.c.6540009.v1
Autor:
Leonidas C. Platanias, Michael E. Berens, Jeffrey Raizer, Priya Kumthekar, Kristiina Vuori, Andrew P. Mazar, Craig Horbinski, Ichiro Nakano, C. David James, Shi-Yuan Cheng, Stewart Goldman, Jessica Clymer, Kristen Alley, Elspeth M. Beauchamp, Barbara Kroczynska, Seungchan Kim, Sen Peng, Darren Finlay, Harshil D. Dhruv, Frank Eckerdt, Jonathan B. Bell
Relates to materials & methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8284b615ae355a63524665941fae0255
https://doi.org/10.1158/1541-7786.22511682.v1
https://doi.org/10.1158/1541-7786.22511682.v1
Autor:
Johann de Bono, Mohammed M. Dar, C. Martin Curtis, Bo Ma, A. Benjamin Suttle, Roger E. McLendon, Jorge Barriuso, Jeffrey Raizer, Steve Rosenfeld, Tom Mikkelsen, Louis Nabors, Patrick Y. Wen, Morris D. Groves, David A. Reardon
PDF file - 82K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb8954667ce67d039a6bd7b135b18a9
https://doi.org/10.1158/1078-0432.22450127.v1
https://doi.org/10.1158/1078-0432.22450127.v1
Autor:
Johann de Bono, Mohammed M. Dar, C. Martin Curtis, Bo Ma, A. Benjamin Suttle, Roger E. McLendon, Jorge Barriuso, Jeffrey Raizer, Steve Rosenfeld, Tom Mikkelsen, Louis Nabors, Patrick Y. Wen, Morris D. Groves, David A. Reardon
PDF file - 182K, Tumor reduction in 3 patients who achieved a partial response following (A) 21 days, (B) 15 months, and (C) 18 months of treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555c9b5970fe8207a3720f2fdd5bb3a7
https://doi.org/10.1158/1078-0432.22450130.v1
https://doi.org/10.1158/1078-0432.22450130.v1