Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jeffrey R. Simard"'
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 5, Pp 790-807 (2020)
Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and
Externí odkaz:
https://doaj.org/article/be08d031896942fa88493875fa401ec6
Autor:
Jeffrey R. Simard, Tova Meshulam, Biju K. Pillai, Michael T. Kirber, Kellen Brunaldi, Su Xu, Paul F. Pilch, James A. Hamilton
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 914-922 (2010)
Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that sequestration of FA is due to the enrichment of caveolin in the cytosolic leaflet and its
Externí odkaz:
https://doaj.org/article/1262d82de30b417b94bd7dccecea83a0
Autor:
Jeffrey R. Simard, Klaus Michelsen, Yan Wang, Chunhua Yang, Beth Youngblood, Barbara Grubinska, Kristin Taborn, Daniel J. Gillie, Kevin Cook, Kyu Chung, Alexander M. Long, Brian E. Hall, Paul L. Shaffer, Robert S. Foti, Jacinthe Gingras
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:56-69
Ion channels are targets of considerable therapeutic interest to address a wide variety of neurologic indications, including pain perception. Current pharmacological strategies have focused mostly on small molecule approaches that can be limited by s
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
mp3 file (6.8 MB). In the inaugural edition of the Cancer Discovery podcast, Executive Editor Mark Landis talks with Matthew Meyerson about his paper, which describes the identification of the DDR2 kinase as a therapeutic target in squamous cell lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e5addd2d5a8ac8b634e34fdba42185
https://doi.org/10.1158/2159-8290.22529081
https://doi.org/10.1158/2159-8290.22529081
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
Supplementary Table 1 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db13f0f0711315c79b59f97a73ae407
https://doi.org/10.1158/2159-8290.22529072
https://doi.org/10.1158/2159-8290.22529072
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f85fe4c83a1a8d4a9016eb995d4c2
https://doi.org/10.1158/2159-8290.22529075.v1
https://doi.org/10.1158/2159-8290.22529075.v1
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
Supplementary Figure Legends 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5345540f2603d5198978a03ea047dd
https://doi.org/10.1158/2159-8290.22529078.v1
https://doi.org/10.1158/2159-8290.22529078.v1
Autor:
Daniel Rauh, Roman K. Thomas, Heidi Greulich, Tzu-Hsiu Chen, Yuki Yuza, Matthäus Getlik, Jeffrey R. Simard, Mirjam Koker, Matthias Rabiller, Lars Ruddigkeit, Jonathan Weiss, Johannes M. Heuckmann, Cecile Reuter, Vijaykumar G. Pawar, Sabine Klüter, Florian Fischer, Martin Peifer, Stefanie Heynck, Haridas B. Rode, Martin L. Sos
Supplementary Figure 2 from Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b33c46cc59f5c4a05c14a3e2762176c
https://doi.org/10.1158/0008-5472.22385273.v1
https://doi.org/10.1158/0008-5472.22385273.v1
Autor:
Daniel Rauh, Roman K. Thomas, Heidi Greulich, Tzu-Hsiu Chen, Yuki Yuza, Matthäus Getlik, Jeffrey R. Simard, Mirjam Koker, Matthias Rabiller, Lars Ruddigkeit, Jonathan Weiss, Johannes M. Heuckmann, Cecile Reuter, Vijaykumar G. Pawar, Sabine Klüter, Florian Fischer, Martin Peifer, Stefanie Heynck, Haridas B. Rode, Martin L. Sos
Supplementary Figure 4 from Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c3adab8e6719a4afeccf3c429f681c
https://doi.org/10.1158/0008-5472.22385267.v1
https://doi.org/10.1158/0008-5472.22385267.v1
Autor:
Daniel Rauh, Roman K. Thomas, Heidi Greulich, Tzu-Hsiu Chen, Yuki Yuza, Matthäus Getlik, Jeffrey R. Simard, Mirjam Koker, Matthias Rabiller, Lars Ruddigkeit, Jonathan Weiss, Johannes M. Heuckmann, Cecile Reuter, Vijaykumar G. Pawar, Sabine Klüter, Florian Fischer, Martin Peifer, Stefanie Heynck, Haridas B. Rode, Martin L. Sos
Reversible epidermal growth factor receptor (EGFR) inhibitors are the first class of small molecules to improve progression-free survival of patients with EGFR-mutated lung cancers. Second-generation EGFR inhibitors introduced to overcome acquired re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c57476dbb8bceb81527d4a605d7f2ff
https://doi.org/10.1158/0008-5472.c.6501170.v1
https://doi.org/10.1158/0008-5472.c.6501170.v1