Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jeffrey R. Sampson"'
Autor:
Mark Gerstein, Jeffrey R. Sampson, Farren J. Isaacs, Jesse Rinehart, Karl W. Barber, Richard V Szeligowski, Paul R. Muir, Svetlana Rogulina
Publikováno v:
Nature biotechnology
Post-translational phosphorylation is essential to human cellular processes, but the transient, heterogeneous nature of this modification complicates its study in native systems. We developed an approach to interrogate phosphorylation and its role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d68aa44e44c4683828905ea2869543
http://europepmc.org/articles/PMC6590076
http://europepmc.org/articles/PMC6590076
Autor:
Benjamin D. Lunstad, Israel Steinfeld, Kenji D Okochi, Laurakay Bruhn, Subhadeep Roy, Daniel E. Ryan, Bo Curry, Magdalena Olesiak, Madhurima Singh, David Taussig, Ryan McCaffrey, Chong Wing Yung, Douglas J. Dellinger, Xuan Vuong, Smruti M Phadnis, Jeffrey R. Sampson
Publikováno v:
Nucleic Acids Research
CRISPR systems have emerged as transformative tools for altering genomes in living cells with unprecedented ease, inspiring keen interest in increasing their specificity for perfectly matched targets. We have developed a novel approach for improving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5983ffc5eb2b92f101efcc6c1144cd11
http://europepmc.org/articles/PMC5778453
http://europepmc.org/articles/PMC5778453
Autor:
Jeffrey R. Sampson
This book began as a series of lecture notes for a course called Introduc tion to Adaptive Systems which I developed for undergraduate Computing Science majors at the University of Alberta and first taught in 1973. The objective of the course has b
Autor:
Dennis A. Dougherty, Wenge Zhong, Patrick C. Kearney, John Abelson, Jon S. Thorson, Peter G. Schultz, Jeffrey R. Sampson, Scott K. Silverman, Mark W. Nowak, Norman Davidson, Cesar Labarca, Henry A. Lester, Margaret E. Saks
Publikováno v:
Science. 268:439-442
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to intact cells and combined with electrophysiological analysis to probe structure-function relations in the nicotinic acetylcholine receptor. Functional re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d477b2784aa0b5094b0eeb779409df3
https://doi.org/10.1126/science.7716551
https://doi.org/10.1126/science.7716551
Publikováno v:
Science. 263:191-197
Correct recognition of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases is central to the maintenance of translational fidelity. The hypothesis that synthetases recognize anticodon nucleotides was proposed in 1964 and had considerable experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812633e09f79cd57c63cb9ae9a422973
https://doi.org/10.1126/science.7506844
https://doi.org/10.1126/science.7506844
Autor:
Fernando Ferreira, Douglas J. Dellinger, John O. Turner, Zoltan Timar, Marvin H. Caruthers, Jeffrey R. Sampson, Joel Myerson, Kenneth W. Hill, Zoltán Kupihár, Agnieszka B. Sierzchala, James A. Powell, Geraldine F Dellinger
Publikováno v:
Journal of the American Chemical Society. 133(30)
An improved method for the chemical synthesis of RNA was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide product using 1,2-diamines under anh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a17d3ac9752513ef811a9342d212de
https://pubmed.ncbi.nlm.nih.gov/21688829
https://pubmed.ncbi.nlm.nih.gov/21688829
Publikováno v:
Nucleic Acids Research. 20:4055-4059
The irradiation of native or unmodified yeast tRNA(Phe) by short wavelength UV light (260 nM) results in an intramolecular crosslink that has been mapped to occur between C48 in the variable loop and U59 in the T loop. Photo-reversibility of the cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f3f316cd7926435d9768acbff7e99e
https://doi.org/10.1093/nar/20.15.4055
https://doi.org/10.1093/nar/20.15.4055
Autor:
Kathleen B. Hall, Jeffrey R. Sampson
Publikováno v:
Nucleic Acids Research. 18:7041-7047
Both NMR and nuclease mapping have been used to probe the structure of an unmodified yeast tRNA(phe) precursor synthesized in vitro by T7 RNA polymerase. A comparison of the NMR data of the precursor and of the mature tRNA transcript shows that the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0b29ae05d24aba20d91f31e38d324b
https://doi.org/10.1093/nar/18.23.7041
https://doi.org/10.1093/nar/18.23.7041
Publikováno v:
Science (New York, N.Y.). 279(5357)
The transfer RNA (tRNA) multigene family comprises 20 amino acid–accepting groups, many of which contain isoacceptors. The addition of isoacceptors to the tRNA repertoire was critical to establishing the genetic code, yet the origin of isoacceptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c6395bb6852e4d8ec7ff1f665fadfd
https://pubmed.ncbi.nlm.nih.gov/9497276
https://pubmed.ncbi.nlm.nih.gov/9497276
Autor:
Jeffrey R. Sampson, Margaret E. Saks
Publisher Summary Most systematic evolution of ligands by exponential enrichment (SELEX) schemes, involving nucleic acid ligands, require some type of postselection amplification of the nucleic acid sequence. This is usually accomplished by the polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8de3afba9e58c4c3ea579e2fb4b8a0
https://doi.org/10.1016/s0076-6879(96)67024-4
https://doi.org/10.1016/s0076-6879(96)67024-4