Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jeffrey R. Patton"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94610 (2014)
The most abundant of the modified nucleosides, and once considered as the "fifth" nucleotide in RNA, is pseudouridine, which results from the action of pseudouridine synthases. Recently, the mammalian pseudouridine synthase 1 (hPus1p) has been report
Externí odkaz:
https://doaj.org/article/b77fe52de2cf4b4cafd706ce10ca8ee1
Autor:
Xiansi Zhao, Jeffrey R. Patton, Remco A. Spanjaard, Ling Shen, Sajal Ghosh, Nathan Fischel-Ghodsian
Publikováno v:
Molecular Endocrinology. 21:686-699
It was previously shown that mouse Pus1p (mPus1p), a pseudouridine synthase (PUS) known to modify certain transfer RNAs (tRNAs), can also bind with nuclear receptors (NRs) and function as a coactivator through pseudouridylation and likely activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbaf0255e4b61e0e97318c29fad3c3
https://doi.org/10.1210/me.2006-0414
https://doi.org/10.1210/me.2006-0414
Autor:
Jeffrey R. Patton, Joshua E. Mangum, Anoop K. Sendamarai, Shayne C. Barlow, Melissa J. Puppa, Hart G.W. Lidov, Nathan Fischel-Ghodsian, Paul J. Schmidt, Diego Altomare, Johnathon Elkes, James A. Carson, Justin P. Hardee, Dean R. Campagna, Dennis K. Fix, Yelena Bykhovskaya, Mark D. Fleming
Publikováno v:
Scientific Reports
Mitochondrial myopathy with lactic acidosis and sideroblastic anemia (MLASA) is an oxidative phosphorylation disorder, with primary clinical manifestations of myopathic exercise intolerance and a macrocytic sideroblastic anemia. One cause of MLASA is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a73d225fbfb9aed9c11d421a129aace
https://pubmed.ncbi.nlm.nih.gov/27197761
https://pubmed.ncbi.nlm.nih.gov/27197761
Autor:
Richard W. Padgett, Jeffrey R. Patton
Publikováno v:
Biochemical Journal. 372:595-602
The formation of pseudouridine (Ψ) from uridine is post-transcriptional and catalysed by pseudouridine synthases, several of which have been characterized from eukaryotes. Pseudouridine synthase 1 (Pus1p) has been well characterized from yeast and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7326e6a820cfbd4b77ffc55b5fae7ec
https://doi.org/10.1042/bj20021938
https://doi.org/10.1042/bj20021938
Autor:
Jianguang Chen, Jeffrey R. Patton
Publikováno v:
Biochemical Journal. 352:465-473
Evidence for the alternative splicing of the message for mouse pseudouridine synthase 1 (mPus1p) was found when several expressed sequence tag clones were completely sequenced. The genomic DNA for the MPUS1 gene (6.9kb) was cloned from a mouse genomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d544ec2f51b89838042f3b0b28bcc1d7
https://doi.org/10.1042/bj3520465
https://doi.org/10.1042/bj3520465
Autor:
Dennis B. Zerby, Jeffrey R. Patton
Publikováno v:
Nucleic Acids Research. 25:4808-4815
Small nuclear RNAs (snRNA), cofactors in the splicing of pre-mRNA, are highly modified. In this report the modification of human U4 RNA was studied using cell extracts and in vitro synthesized, and therefore unmodified, U4 RNA. The formation of pseud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6726fa823b4377770584a09e7606e259
https://doi.org/10.1093/nar/25.23.4808
https://doi.org/10.1093/nar/25.23.4808
Autor:
Jeffrey R. Patton, Bryan S. Sibert
Publikováno v:
Nucleic Acids Research
Pseudouridine synthase 1 (Pus1p) is an unusual site-specific modification enzyme in that it can modify a number of positions in tRNAs and can recognize several other types of RNA. No consensus recognition sequence or structure has been identified for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8aba0137f81a1957484a590751e69ad
https://pubmed.ncbi.nlm.nih.gov/22102571
https://pubmed.ncbi.nlm.nih.gov/22102571
Pseudouridine synthase 1 (Pus1p) is an enzyme that converts uridine to Pseudouridine (Ψ) in tRNA and other RNAs in eukaryotes. The active site of Pus1p is composed of stretches of amino acids that are highly conserved and it is hypothesized that mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7735f199361870985d576d6f715a010
https://europepmc.org/articles/PMC2525951/
https://europepmc.org/articles/PMC2525951/
A previously unidentified activity of yeast and mouse RNA:pseudouridine synthases 1 (Pus1p) on tRNAs
Autor:
Christiane Branlant, Isabelle Behm-Ansmant, FranÇoise Immel, Jeffrey R. Patton, Yuri Motorin, Séverine Massenet
Publikováno v:
RNA
RNA, Cold Spring Harbor Laboratory Press, 2006, 12 (8), pp.1583-1593. ⟨10.1261/rna.100806⟩
RNA, Cold Spring Harbor Laboratory Press, 2006, 12 (8), pp.1583-1593. ⟨10.1261/rna.100806⟩
Mouse pseudouridine synthase 1 (mPus1p) was the first vertebrate RNA:pseudouridine synthase that was cloned and characterized biochemically. The mPus1p was previously found to catalyze Ψ formation at positions 27, 28, 34, and 36 in in vitro produced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4584e85a3402d471c45a584b2828128f
https://hal.archives-ouvertes.fr/hal-02279876
https://hal.archives-ouvertes.fr/hal-02279876
Autor:
Jeffrey R. Patton, Richard W. Padgett
Publikováno v:
BMC Molecular Biology
BMC Molecular Biology, Vol 6, Iss 1, p 20 (2005)
BMC Molecular Biology, Vol 6, Iss 1, p 20 (2005)
BackgroundPseudouridine (Ψ) is an abundant modified nucleoside in RNA and a number of studies have shown that the presence of Ψ affects RNA structure and function. The positions of Ψ in spliceosomal small nuclear RNAs (snRNAs) have been determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23621b217dc2fe58aee75ea7a3fa021
https://doi.org/10.1186/1471-2199-6-20
https://doi.org/10.1186/1471-2199-6-20