Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jeffrey R. Moffitt"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. While single-cell omics studies have identified more than 120 different neuronal subtypes in the mouse retina, little
Externí odkaz:
https://doaj.org/article/054556ca0bec4257ba6a1ae32ea5af58
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bb61ba9be03a49f5bc6f9d4f85fc2f0a
Autor:
Ernest Aw, Stacie L. Lin, Yingying Zhang, Uli Herrmann, Esra Yalcin, Kent Langston, Carlos Castrillion, Minghe Ma, Jeffrey R. Moffitt, Michael C. Carroll
Publikováno v:
bioRxiv
Among systemic lupus erythematosus (SLE) patients, neuropsychiatric symptoms are highly prevalent, being observed in up to 80% of adult and 95% of pediatric patients. Type 1 interferons, particularly interferon alpha (IFNα), have been implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1be7f9fa316b946bc54fe520424e2fd
https://europepmc.org/articles/PMC10153248/
https://europepmc.org/articles/PMC10153248/
Autor:
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C. Macbeth, Elyza A. Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S. Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M. Chiu, Jeffrey R. Moffitt, Ansel Hsiao, John J. Mekalanos, Christophe Benoist, Dennis L. Kasper
Publikováno v:
bioRxiv
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement component 3 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e123493ed381fc22f2f57e2ae0c488
https://europepmc.org/articles/PMC9915568/
https://europepmc.org/articles/PMC9915568/
Autor:
Aritra Bhattacherjee, Chao Zhang, Brianna Watson, Mohamed Nadhir Djekidel, Jeffrey R. Moffitt, Yi Zhang
The prefrontal cortex (PFC) is functionally one of the most complex regions of mammalian brain. Unlike other cortical areas that process single sensory modalities (like vision, touch, smell, etc.), the PFC integrates information across brain regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b7f5d52ab4525094ce7cde7da5fb8ff
https://doi.org/10.1101/2022.12.29.522242
https://doi.org/10.1101/2022.12.29.522242
SummaryThe visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. We performed spatial transcriptomic profiling of over 100,000 cells from the mouse retina, uncovering the spatial distri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2570900c3bd5d4626357d7d83333787
https://doi.org/10.1101/2022.12.04.518972
https://doi.org/10.1101/2022.12.04.518972
Autor:
Jeffrey R. Moffitt, Peter V. Kharchenko, Paolo Cadinu, Ruslan A. Soldatov, Rosalind J. Xu, Viktor Petukhov, Konstantin Khodosevich
Publikováno v:
Nature Biotechnology. 40:345-354
Single-molecule spatial transcriptomics protocols based on in situ sequencing or multiplexed RNA fluorescent hybridization can reveal detailed tissue organization. However, distinguishing the boundaries of individual cells in such data is challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a986a2d67b760bf04dc189ba5e1c51dc
https://doi.org/10.1038/s41587-021-01044-w
https://doi.org/10.1038/s41587-021-01044-w
Publikováno v:
eLife, Vol 5 (2016)
Spatial organization of the transcriptome has emerged as a powerful means for regulating the post-transcriptional fate of RNA in eukaryotes; however, whether prokaryotes use RNA spatial organization as a mechanism for post-transcriptional regulation
Externí odkaz:
https://doaj.org/article/fe66283bb28f4ed4870fcbbacd4b37b2
Autor:
Kevin Petrecca, Alexandre Prat, John A. Heyman, Burkhard Becher, Jack P. Antel, Zhaorong Li, Michael A. Wheeler, Giulia Scalisi, Assaf Rotem, Charles P. Couturier, Liliana Maria Sanmarco, Iain C. Clark, Jeffrey R. Moffitt, Shravan Thaploo, Francisco J. Quintana, Stephanie Zandee, David A. Weitz, Veit Rothhammer, Jiannis Ragoussis, Sarah Alkwai, Brianna R. Watson, Emily C. Tjon
Publikováno v:
Nature, vol 578, iss 7796
Nature
Nature
Multiple sclerosis is a chronic inflammatory disease of the CNS(1). Astrocytes contribute to the pathogenesis of multiple sclerosis(2), but little is known about the heterogeneity of astrocytes and its regulation. Here we report the analysis of astro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c227ccf8cc3c4b90543672124d232485
https://doi.org/10.1038/s41586-020-1999-0
https://doi.org/10.1038/s41586-020-1999-0
Publikováno v:
Nature Reviews Genetics
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein profiling methods as a major pillar for cellular atlas building of complex samples, from tissues to full organisms. Emerging methods yield omics measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87118efacad49636bed8284f15085d1d