Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jeffrey R. Millman"'
Autor:
Marlie M. Maestas, Matthew Ishahak, Punn Augsornworawat, Daniel A. Veronese-Paniagua, Kristina G. Maxwell, Leonardo Velazco-Cruz, Erica Marquez, Jiameng Sun, Mira Shunkarova, Sarah E. Gale, Fumihiko Urano, Jeffrey R. Millman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing from human samples and studies using in vitro and in vivo models suggest that endoplasmic reticulum and inflammatory signaling play an important r
Externí odkaz:
https://doaj.org/article/384db0eca8114c448f1019714f611871
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Diabetes cell replacement therapy has the potential to be transformed by human pluripotent stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in relationship to primary fetal and adult β-cells remains unc
Externí odkaz:
https://doaj.org/article/c0e2562a64d84edba75d1a2a6353b1ca
Autor:
Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark J. Henderson, Jeffrey R. Millman, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram
Externí odkaz:
https://doaj.org/article/24a5fd515d1d461683a1b821a7ee0008
Autor:
Debkalpa Goswami, Daniel A. Domingo‐Lopez, Niamh A. Ward, Jeffrey R. Millman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche
Publikováno v:
Advanced Science, Vol 8, Iss 16, Pp n/a-n/a (2021)
Abstract Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to
Externí odkaz:
https://doaj.org/article/4cf0798c8ca246f8b21fe8ecf5742881
Autor:
Leonardo Velazco-Cruz, Jiwon Song, Kristina G. Maxwell, Madeleine M. Goedegebuure, Punn Augsornworawat, Nathaniel J. Hogrebe, Jeffrey R. Millman
Publikováno v:
Stem Cell Reports, Vol 12, Iss 2, Pp 351-365 (2019)
Summary: Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have generated insulin-producing cells resembling pancreatic β cells. While these stem cell-derived β (SC-β) cells are capable of undergoing glucose-stimulate
Externí odkaz:
https://doaj.org/article/e0b99cbc138d49ee89ca9341cbfe50d4
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100238- (2021)
Summary: Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These advances are enabling in vitro disease modeling studies
Externí odkaz:
https://doaj.org/article/b241cef2e79f47fdbed90a2ed9d304dd
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108850- (2021)
Externí odkaz:
https://doaj.org/article/81c86e686f9d4ebfbab552bc82af5ad5
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108067- (2020)
Summary: Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet organoids could provide an unlimited cell source for diabetes cell replacement therapy. However, current SC-β cells generated in vitro are tran
Externí odkaz:
https://doaj.org/article/53f7bf141973425f9f8e9f84420f1906
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human
Externí odkaz:
https://doaj.org/article/4ec2b80bd10a4bdc837d437747074b1e
Autor:
Leonardo Velazco-Cruz, Madeleine M. Goedegebuure, Kristina G. Maxwell, Punn Augsornworawat, Nathaniel J. Hogrebe, Jeffrey R. Millman
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature
Externí odkaz:
https://doaj.org/article/7a25372c70bc4406a4a89c2dd99e4bef