Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffrey R. May"'
Autor:
Tangpo Yang, Adolfo Cuesta, Xiaobo Wan, Gregory B. Craven, Brad Hirakawa, Penney Khamphavong, Jeffrey R. May, John C. Kath, John D. Lapek, Sherry Niessen, Alma L. Burlingame, Jordan D. Carelli, Jack Taunton
Publikováno v:
Nature chemical biology, vol 18, iss 9
Nat Chem Biol
Nat Chem Biol
The expansion of the target landscape of covalent inhibitors requires the engagement of nucleophiles beyond cysteine. Although the conserved catalytic lysine in protein kinases is an attractive candidate for a covalent approach, selectivity remains a
Autor:
Jeffrey R. May, Kimbie Palacio, Jianying Wang, Brad Hirakawa, Ling Liu, Yizhong Zhang, Gregory J. Stevens, Shirley A. Aguirre, Winston Evering
Publikováno v:
Toxicologic Pathology. 42:1117-1129
This investigation examined microRNA-208a (miR-208a) as a potential biomarker of isoproterenol (ISO)-induced cardiac injury in superoxide dismutase-2 ( Sod2+/−) and the wild-type mice, and the potential sensitivity of Sod2+/− mice to ISO-induced
Autor:
Wesley Scott, Robert H. Denlinger, Sophia Randolph, Natilie Hosea, Ling Liu, Bora Han, Jeffrey R. May, Shirley A. Aguirre, Leigh Ann Burns-Naas
Publikováno v:
Toxicologic Pathology. 42:422-434
Dexamethasone was given in 2 oral dosing regimens with repeat dose oral administration of the gamma secretase inhibitor (GSI), PF-03084014, in Sprague-Dawley (SD) rats in order to evaluate the effects of coadministration of dexamethasone on GSI-induc
Publikováno v:
Toxicologic Pathology. 32:413-417
Female Tg rasH2 (CB6F1/Jic-TgrasH2@Tac) mice were administered water once daily, water twice daily with 8 or 12 hours between doses, 1% sodium dodecyl sulfate in water (1% SDS) once daily, or 1% SDS twice daily with 12 hours between doses by oral gav
Publikováno v:
Environmental Toxicology and Chemistry. 21:347-352
While it is generally accepted that water hardness affects copper toxicity, the major ions that contribute to water hardness (calcium [Ca] and magnesium [Mg]) may affect copper toxicity differently. This is important because the Ca:Mg ratio in standa
Autor:
Frederick Sace, Jeffrey R. May, Justine L. Lam, Dusko Trajkovic, Brad Hirakawa, Jonathan R. Heyen, Eileen R. Blasi, Allison Vitsky, Timothy C. Nichols, Gina M. Yanochko
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 135(2)
The fibroblast growth factor receptors (FGFR) play a major role in angiogenesis and are desirable targets for the development of therapeutics. Groups of Wistar Han rats were dosed orally once daily for 4 days with a small molecule pan-FGFR inhibitor
Publikováno v:
Environmental toxicology and chemistry. 21(2)
While it is generally accepted that water hardness affects copper toxicity, the major ions that contribute to water hardness (calcium [Ca] and magnesium [Mg]) may affect copper toxicity differently. This is important because the Ca:Mg ratio in standa
Autor:
Jonathan R. Heyen, Marlo Volberg, Aida Sacaan, Jeffrey R. May, Wesley Scott, Jill Steidl, Aileen D. McHarg, Nancy Poy, Kimbie Palacio, Steve Foote
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e41-e42
Autor:
Gina M. Yanochko, Jeffrey R. May, Joseph D. Jamieson, Jonathan R. Heyen, Aileen McHarg, Allison Vitsky, Eileen R. Blasi
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 68:e19