Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jeffrey R. Koenitzer"'
Autor:
Amjad Horani, Deepesh Kumar Gupta, Jian Xu, Huihui Xu, Lis del Carmen Puga-Molina, Celia M. Santi, Sruthi Ramagiri, Steven K. Brennan, Jiehong Pan, Jeffrey R. Koenitzer, Tao Huang, Rachael M. Hyland, Sean P. Gunsten, Shin-Cheng Tzeng, Jennifer M. Strahle, Pleasantine Mill, Moe R. Mahjoub, Susan K. Dutcher, Steven L. Brody
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown. We used CRISPR-Cas9 g
Externí odkaz:
https://doaj.org/article/a8958a20c7784cb38752182a624f9384
Autor:
Jeffrey R. Koenitzer, Gustavo Bonacci, Steven R. Woodcock, Chen-Shan Chen, Nadiezhda Cantu-Medellin, Eric E. Kelley, Francisco J. Schopfer
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 1-10 (2016)
Nitro-fatty acids (NO2-FA) are metabolic and inflammatory-derived electrophiles that mediate pleiotropic signaling actions. It was hypothesized that NO2-FA would impact mitochondrial redox reactions to induce tissue-protective metabolic shifts in cel
Externí odkaz:
https://doaj.org/article/734c0fe8f5364d86a1484b0e58752578
Autor:
Sonia R. Salvatore, Dario A. Vitturi, Paul R.S. Baker, Gustavo Bonacci, Jeffrey R. Koenitzer, Steven R. Woodcock, Bruce A. Freeman, Francisco J. Schopfer
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1998-2009 (2013)
The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction. The formation of 9-NO2-octadeca-9,11-dienoic acid and 12-NO2-octadeca-9,11-dienoic acid ste
Externí odkaz:
https://doaj.org/article/61ca34640d3b4f0b88b5342113ee5343
Autor:
Guy Hazan, Anna Eubanks, Carrie Gierasch, Jeffrey Atkinson, Carolyn Fox, Ariel Hernandez-Leyva, Anne L. Rosen, Andrew L. Kau, Eugene Agapov, Jennifer Alexander-Brett, Deborah Steinberg, Diane Kelley, Michael White, Derek Byers, Kangyun Wu, Shamus P. Keeler, Yong Zhang, Jeffrey R. Koenitzer, Elise Eiden, Neil Anderson, Michael J. Holtzman, Jeffrey Haspel
Publikováno v:
J Immunol
Asthma is a chronic disease of childhood, but for unknown reasons, disease activity sometimes subsides as children mature. In this study, we present clinical and animal model evidence suggesting that the age dependency of childhood asthma stems from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46463e84abef43f97a09844c6e2f2dfb
https://doi.org/10.4049/jimmunol.2101094
https://doi.org/10.4049/jimmunol.2101094
Autor:
Hannah Luehmann, Amber Salter, Benjamin D. Humphreys, Jeffrey J. Atkinson, Gyu Seong Heo, Yongjian Liu, Adrian Shifren, Cedric Mpoy, Christophe Combadière, Michelle Hoelscher, Sean P. Gunsten, Daniel Kreisel, Ethan C. Lee, Buck E. Rogers, Shuchi Guo, Tonya D. Russell, Jiehong Pan, Jeffrey R. Koenitzer, Delphine L. Chen, Derek E. Byers, Richard Laforest, Kory J. Lavine, Deborah H. Sultan, Tao Huang, Steven L. Brody, David S. Gierada, Robert J. Gropler
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:78-89
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease without effective molecular markers of disease activity or treatment responses. Monocyte and interstitial m...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9aba66372ad9a17457625ed13cfe080
https://doi.org/10.1164/rccm.202004-1132oc
https://doi.org/10.1164/rccm.202004-1132oc
Autor:
Jeffrey R. Koenitzer, Anne Rosen, Guy Hazan, Yong Zhang, Carolyn Fox, Michael J. Holtzman, Andrew L. Kau, Shamus P. Keeler, Jeffrey J. Atkinson, Carrie Gierasch, Jennifer Alexander-Brett, Anna Eubanks, Derek E. Byers, Eugene Agapov, Deborah Lynn Steinberg, Diane G. Kelley, Michael White, Jeffrey A. Haspel, Ariel Hernandez-Leyva, Kangyun Wu
Asthma is a common chronic disease of childhood, but for unknown reasons disease activity sometimes subsides as children mature. To understand why, we exposed mice across a range of ages to viral and allergic triggers of asthma exacerbations and airw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58439c9f0ce3a2d38064135fdaeb1f9d
https://doi.org/10.21203/rs.3.rs-544240/v1
https://doi.org/10.21203/rs.3.rs-544240/v1
Publikováno v:
Am J Respir Cell Mol Biol
Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell types by death or inadequate dissociation, and transcriptional stress responses induced durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576ce4ecb8e9b465ae71ae71a56ce469
https://europepmc.org/articles/PMC7790136/
https://europepmc.org/articles/PMC7790136/
Autor:
Shuchi Guo, Tonya D. Russell, Christophe Combadière, Derek E. Byers, Benjamin D. Humphreys, Jeffrey R. Koenitzer, Kory J. Lavine, Hannah Luehmann, Jiehong Pan, Adrian Shifren, Gyu Seong Heo, Amber Salter, David S. Gierada, Ethan C. Lee, Sean P. Gunsten, Robert J. Gropler, Daniel Kreisel, Jeffrey J. Atkinson, Michelle Hoelscher, Deborah H. Sultan, Tao Huang, Steven L. Brody, Richard Laforest, Yongjian Liu, Cedric Mpoy, Delphine L. Chen, Buck E. Rogers
Idiopathic pulmonary fibrosis (IPF) is a progressive, inflammatory lung disease that is monitored clinically by measures of lung function, without effective molecular markers of disease activity or therapeutic efficacy. Lung immune cells active in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b309dae1fbae679b094449221cf2581c
https://doi.org/10.1101/2020.03.04.960179
https://doi.org/10.1101/2020.03.04.960179
Autor:
Nicolas A. Stewart, Francisco J. Schopfer, Gustavo Bonacci, Steven R. Woodcock, Jeffrey R. Koenitzer, Sonia R. Salvatore, Nobunao Wakabayashi, Thomas W. Kensler, Bruce A. Freeman, Chen Shan Chen, Dario A. Vitturi
Publikováno v:
Journal of Biological Chemistry. 288:25626-25637
Inflammation, characterized by the activation of both resident and infiltrated immune cells, is accompanied by increased production of oxidizing and nitrating species. Nitrogen dioxide, the proximal nitrating species formed under these conditions, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9018b522fb1c480a6c0905369a5a9d4
https://doi.org/10.1074/jbc.m113.486282
https://doi.org/10.1074/jbc.m113.486282
Autor:
Francisco J. Schopfer, Sonia R. Salvatore, Gustavo Bonacci, Jeffrey R. Koenitzer, Paul R. S. Baker, Dario A. Vitturi, Steven R. Woodcock, Bruce A. Freeman
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1998-2009 (2013)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction. The formation of 9-NO2-octadeca-9,11-dienoic acid and 12-NO2-octadeca- 9,11-dienoic acid st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6037bbcd5b293a5cfeda8196b0d1b54a
https://doi.org/10.1194/jlr.m037804
https://doi.org/10.1194/jlr.m037804