Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jeffrey R. Keefer"'
Autor:
Michael A Krause, Seidina A S Diakite, Tatiana M Lopera-Mesa, Chanaki Amaratunga, Takayuki Arie, Karim Traore, Saibou Doumbia, Drissa Konate, Jeffrey R Keefer, Mahamadou Diakite, Rick M Fairhurst
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37214 (2012)
α-Thalassemia results from decreased production of α-globin chains that make up part of hemoglobin tetramers (Hb; α(2)β(2)) and affects up to 50% of individuals in some regions of sub-Saharan Africa. Heterozygous (-α/αα) and homozygous (-α/-
Externí odkaz:
https://doaj.org/article/b922aa020f984573a150af1c23910ff3
Autor:
Chanaki Amaratunga, Tatiana M Lopera-Mesa, Nathaniel J Brittain, Rushina Cholera, Takayuki Arie, Hisashi Fujioka, Jeffrey R Keefer, Rick M Fairhurst
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14798 (2011)
In Africa, infant susceptibility to Plasmodium falciparum malaria increases substantially as fetal hemoglobin (HbF) and maternal immune IgG disappear from circulation. During the first few months of life, however, resistance to malaria is evidenced b
Externí odkaz:
https://doaj.org/article/1ec8f3ce6e7541679428b70da5439344
Autor:
Shirley H. Purvis, Emily Barron-Casella, Jeffrey R. Keefer, Yolanda M. Fortenberry, James F. Casella
Publikováno v:
Nucleic acid therapeutics. 27(6)
The pathophysiology of sickle cell disease (SCD) is dependent on the polymerization of deoxygenated sickle hemoglobin (HbS), leading to erythrocyte deformation (sickling) and vaso-occlusion within the microvasculature. Following deoxygenation, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c742047eba2cf0edd3260f8b34bce0
https://pubmed.ncbi.nlm.nih.gov/29039727
https://pubmed.ncbi.nlm.nih.gov/29039727
Autor:
Hetty E. Carraway, Natalie Uy, Steven D. Gore, Sarah Sakoian, Thomas Prebet, Katharine R. Press, Jeffrey R. Keefer
Publikováno v:
Leukemialymphoma. 59(3)
Hemoglobinopathies are inherited disorders of globin chains leading to decreased production of hemoglobin (Hb), the most significant being sickle cell disease (SCD) and β-thalassemia. Expression of...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb45aa7aa350f947055c91d09a84b54
https://pubmed.ncbi.nlm.nih.gov/28738707
https://pubmed.ncbi.nlm.nih.gov/28738707
Autor:
William A. Wargin, Lynne Neumayr, Richard J. Labotka, Marvin Reid, Jeffrey R. Keefer, Kenneth I. Ataga, Ronald J. Berenson, Jonathan Glass, Abdullah Kutlar, Loray A Blair-Britt, Susan P. Perrine, Elliott Vichinsky
Publikováno v:
American Journal of Hematology. 87:1017-1021
Therapeutics which reduce the pathology in sickle cell syndromes are needed, particularly noncytotoxic therapeutics. Fetal hemoglobin (HbF, α(2) γ(2) ) is established as a major regulator of disease severity; increased HbF levels correlate with mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52646293447c428c4fff45a62f7446a2
https://doi.org/10.1002/ajh.23306
https://doi.org/10.1002/ajh.23306
Autor:
Gloria Shin, Kirby D. Smith, Shirley H. Purvis, Tonya Schneidereith, Gao X. Dong, Forrest Spencer, Rebecca Deering Brose, Jeffrey R. Keefer, Martina C. McGuinness
Publikováno v:
Human Molecular Genetics. 21:4237-4252
Various small molecule pharmacologic agents with different known functions produce similar outcomes in diverse Mendelian and complex disorders, suggesting that they may induce common cellular effects. These molecules include histone deacetylase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a958442ff0b5f940ba9b6515c0a05a54
https://doi.org/10.1093/hmg/dds247
https://doi.org/10.1093/hmg/dds247
Publikováno v:
Pediatric Radiology. 39:1105-1109
Littoral cell angioma (LCA) is a rare primary splenic vascular tumor originating from littoral cells lining the splenic red pulp sinuses. LCAs are rarely seen in children. We present the US, CT, and MRI findings including diffusion-weighted imaging (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e02a9bb142ae807f7a6a3ce059dc253
https://doi.org/10.1007/s00247-009-1339-x
https://doi.org/10.1007/s00247-009-1339-x
Autor:
Kortney Hensley, Alan D. Friedman, Dehua Wang, Jeffrey R. Keefer, Dong Hong Cai, Christine Yeamans
Publikováno v:
Oncogene. 27:2772-2779
The basic-region leucine zipper (BR-LZ or bZIP) transcription factors dimerize via their LZ domains to position the adjacent BRs for DNA-binding. Members of the C/EBP, AP-1, and CREB/ATF bZIP subfamilies form homodimeric or heterodimeric complexes wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d49e6a9d1397a06bd449857c53fab6b
https://doi.org/10.1038/sj.onc.1210940
https://doi.org/10.1038/sj.onc.1210940
Publikováno v:
Pediatric Blood & Cancer. 50:1006-1012
Background Acute chest syndrome (ACS) is a frequent cause of hospitalization and mortality in children with sickle cell disease. Transfusion is often required to prevent respiratory failure and treatment with dexamethasone may reduce the length of ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff7a71c34cf1b0978b8ab1db5f91a437
https://doi.org/10.1002/pbc.21336
https://doi.org/10.1002/pbc.21336
Autor:
Jason W. Griffith, John R. David, Jeffrey R. Keefer, Richard Bucala, Michael A. McDevitt, Philip E. Thuma, Shanmugasundaram Ganapathy-Kanniappan, Robert A. Mitchell, Victor R. Gordeuk, Jianlin Xie, Lin Leng, Courtney McDonald, Christine N. Metz, Aihua Liu
Publikováno v:
The Journal of Experimental Medicine
The pathogenesis of malarial anemia is multifactorial, and the mechanisms responsible for its high mortality are poorly understood. Studies indicate that host mediators produced during malaria infection may suppress erythroid progenitor development (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d84bf3743b46dc63a2883fceb8586c2
http://europepmc.org/articles/PMC2121202
http://europepmc.org/articles/PMC2121202