Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Jeffrey R. Jacobson"'
Autor:
Joseph B. Mascarenhas, Jin H. Song, Amir A. Gaber, Jeffrey R. Jacobson, Anne E. Cress, Sara M. Camp, Steven M. Dudek, Joe G.N. Garcia
Publikováno v:
Cellular Physiology and Biochemistry, Vol 56, Iss 4, Pp 329-339 (2022)
Externí odkaz:
https://doaj.org/article/db45225a52274a1eb20b98fc2c190c6f
Publikováno v:
Cells, Vol 12, Iss 19, p 2405 (2023)
GADD45a is a gene we previously reported as a mediator of responses to acute lung injury. GADD45a−/− mice express decreased Akt and increased Akt ubiquitination due to the reduced expression of UCHL1 (ubiquitin c-terminal hydrolase L1), a deubiqu
Externí odkaz:
https://doaj.org/article/cc7629dd72504c6eb730d3d408293d4b
Autor:
Tadeo Bermudez, Saad Sammani, Jin H. Song, Vivian Reyes Hernon, Carrie L. Kempf, Alexander N. Garcia, Jessica Burt, Matthew Hufford, Sara M. Camp, Anne E. Cress, Ankit A. Desai, Viswanathan Natarajan, Jeffrey R. Jacobson, Steven M. Dudek, Leopoldo C. Cancio, Julie Alvarez, Ruslan Rafikov, Yansong Li, Donna D. Zhang, Nancy G. Casanova, Christian Bime, Joe G. N. Garcia
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Despite encouraging preclinical data, therapies to reduce ARDS mortality remains a globally unmet need, including during the COVID-19 pandemic. We previously identified extracellular nicotinamide phosphoribosyltransferase (eNAMPT) as a novel
Externí odkaz:
https://doaj.org/article/092e7e48d86844b5b1f80cb4299618f7
Autor:
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-10 (2021)
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton. The curr
Externí odkaz:
https://doaj.org/article/92ff608ff26f4a6a889aba835f82792f
Autor:
Jahar Bhattacharya, Robert Booy, Arturo Casadevall, Charles Dela Cruz, David S. Fedson, Joe G. N. Garcia, Gary Grohmann, Ivan F. N. Hung, Jeffrey R. Jacobson, Lance C. Jennings, Lester Kobzik, Aleksandra Leligdowicz, James K. Liao, Jennifer H. Martin, Daniel M. Musher, Charles N. Serhan, Masato Tashiro
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/d9ffadb6015e4a5c97dba6f06a4fba3a
Autor:
Saad Sammani, Tadeo Bermudez, Carrie L. Kempf, Jin H. Song, Justin C Fleming, Vivian Reyes Hernon, Matthew Hufford, Lin Tang, Hua Cai, Sara M. Camp, Viswanathan Natarajan, Jeffrey R. Jacobson, Steven M. Dudek, Diego R. Martin, Christof Karmonik, Xiaoguang Sun, Belinda Sun, Nancy G. Casanova, Christian Bime, Joe G. N. Garcia
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic that neut
Externí odkaz:
https://doaj.org/article/2c8776f9cbd24ddda8cb97066773d1c8
Autor:
Weiguo Chen, Jamie M. C. Gard, Yulia Epshtein, Sara M. Camp, Joe G. N. Garcia, Jeffrey R. Jacobson, Anne E. Cress
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
We previously reported integrin beta 4 (ITGB4) is an important mediator of lung vascular protection by simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A-reductase inhibitor. In this study, we report increased endothelial cell (EC) expression speci
Externí odkaz:
https://doaj.org/article/e0971b32a5dd486899a2d375875b9e94
Autor:
Mariam Anis, Janae Gonzales, Rachel Halstrom, Noman Baig, Cat Humpal, Regaina Demeritte, Yulia Epshtein, Jeffrey R. Jacobson, Dustin R. Fraidenburg
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13641 (2022)
Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction, uncontrolled proliferation and migration of pulmonary arterial endothelial cells leading to increased pulmonary vascular resistance resulting in great morbidity and po
Externí odkaz:
https://doaj.org/article/496dc8ffbb8042688737a9a49395c14f
Publikováno v:
Cells, Vol 10, Iss 9, p 2186 (2021)
We previously reported that claudin-5, a tight junctional protein, mediates lung vascular permeability in a murine model of acute lung injury (ALI) induced by lipopolysaccharide (LPS). Recently, it has been reported that haloperidol, an antipsychotic
Externí odkaz:
https://doaj.org/article/b4fe4d063ecd478a869f0676c2211547
Autor:
Yulia Epshtein, Ramaswamy Ramchandran, Anne E. Cress, Jeffrey R. Jacobson, Panfeng Fu, Joe G.N. Garcia, Joseph B Mascarenhas, Viswanathan Natarajan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
We have shown that both reactive oxygen species (ROS) and paxillin tyrosine phosphorylation regulate LPS-induced human lung endothelial permeability. Mitochondrial ROS (mtROS) is known to increase endothelial cell (EC) permeability which requires dyn