Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Jeffrey R Mann"'
Autor:
Michelle C W Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, An Tran, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004964 (2015)
Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can acc
Externí odkaz:
https://doaj.org/article/fbdbd16026c44294a31791d6aec3ee14
Autor:
Hsiao P. J. Voon, Linda Hii, Andrew Garvie, Maheshi Udugama, Brian Krug, Caterina Russo, Anderly C. Chüeh, Roger J. Daly, Alison Morey, Toby D. M. Bell, Stephen J. Turner, Joseph Rosenbluh, Paul Daniel, Ron Firestein, Jeffrey R. Mann, Philippe Collas, Nada Jabado, Lee H. Wong
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Background Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas. These H3.3 point mutations affect many chromatin modifications but the exact
Externí odkaz:
https://doaj.org/article/1023758b231c48e2b46f0fc49daf209d
Autor:
Jonathan Ip, Paul Canham, K H Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002919 (2012)
Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are required for the proper assembly of heterochromatin. More recent studies have postulated tha
Externí odkaz:
https://doaj.org/article/6f5656b252bc45f69ef5080e7c43c94c
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000803 (2010)
The misexpressed imprinted genes causing developmental failure of mouse parthenogenones are poorly defined. To obtain further insight, we investigated misexpressions that could cause the pronounced growth deficiency and death of fetuses with maternal
Externí odkaz:
https://doaj.org/article/87ca97e4b9564994826f3fecf09ad8e7
Autor:
Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108729- (2021)
Summary: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) are imprinting disorders manifesting as aberrant fetal growth and severe postnatal-growth-related complications. Based on the insulator model, one-third of BWS cases and two
Externí odkaz:
https://doaj.org/article/3c6bac68b35c49c3ac02056d59a4d489
Publikováno v:
Reproduction Reborn ISBN: 0197616194
Positive impacts on human health can occasionally arise from adopting techniques and approaches developed for entirely different purposes. Mitochondrial replacement therapy (MRT), also referred to as mitochondrial donation, is an example. Its origins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3df4f24b5ade603b07ac44d1f8673a
https://doi.org/10.1093/oso/9780197616192.003.0002
https://doi.org/10.1093/oso/9780197616192.003.0002
Most paediatric diffuse intrinsic pontine gliomas carry a lysine- to methionine-27 (K27M) mutation in the histone variant H3.3 encoded by the ‘H3.3 histone A’ (H3F3A) gene. To establish a pre-clinical model of the disease we made a Cre/loxPcondit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fe8c9b4e75636d0a9c13964d092c243
https://doi.org/10.1101/2022.11.25.518018
https://doi.org/10.1101/2022.11.25.518018
Autor:
Jacob R. Tremblay, Jose Ortiz, Janine C. Quijano, Heather Zook, Jeanne M. LeBon, Wendong Li, Kevin Jou, Walter Tsark, Jeffrey R. Mann, Mark Kozlowski, David A. Tirrell, Farzad Esni, Dannielle D. Engle, Arthur D. Riggs, Hsun Teresa Ku
Pancreatic ducts function to deliver digestive enzymes into the intestines. Upon injury, ducts can become proliferative and contribute to tissue regeneration; however, the identity of the ductal cells that contribute to these processes is unknown. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e36551482d784e9344f96e4a87e4e1
https://doi.org/10.1101/2022.07.12.499653
https://doi.org/10.1101/2022.07.12.499653
Autor:
Deepak Adhikari, In-won Lee, Usama Al-Zubaidi, Jun Liu, Qing-Hua Zhang, Wai Shan Yuen, Likun He, Yasmyn Winstanley, Hiromi Sesaki, Jeffrey R. Mann, Rebecca L. Robker, John Carroll
Publikováno v:
Science advances. 8(24)
Eggs contain about 200,000 mitochondria that generate adenosine triphosphate and metabolites essential for oocyte development. Mitochondria also integrate metabolism and transcription via metabolites that regulate epigenetic modifiers, but there is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ce12ab3cfac6b3a31f31a3109488c0
https://pubmed.ncbi.nlm.nih.gov/35704569
https://pubmed.ncbi.nlm.nih.gov/35704569
Autor:
Maheshi Udugama, Benjamin Vinod, F Lyn Chan, Linda Hii, Andrew Garvie, Philippe Collas, Paul Kalitsis, David Steer, Partha P Das, Pratibha Tripathi, Jeffrey R Mann, Hsiao P J Voon, Lee H Wong
Publikováno v:
Nucleic acids research. 50(8)
Histone H3.3 is an H3 variant which differs from the canonical H3.1/2 at four residues, including a serine residue at position 31 which is evolutionarily conserved. The H3.3 S31 residue is phosphorylated (H3.3 S31Ph) at heterochromatin regions includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7694af86c81c832f7d1132a5db7915
https://pubmed.ncbi.nlm.nih.gov/35451487
https://pubmed.ncbi.nlm.nih.gov/35451487