Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jeffrey R Liddell"'
Autor:
James B. W. Hilton, Kai Kysenius, Jeffrey R. Liddell, Stephen W. Mercer, Bence Paul, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Dominic J. Hare, Blaine R. Roberts, Peter J. Crouch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The copper compound CuII(atsm) has progressed to phase 2/3 testing for treatment of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII(atsm) is neuroprotective in mutant SOD1 mouse models of ALS where its activity is asc
Externí odkaz:
https://doaj.org/article/236516f7a4ca40819c0aeb1e8d9cbdfc
Autor:
Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing ne
Externí odkaz:
https://doaj.org/article/c1c1ef71cd304efcb8d9a959888a9cd7
Autor:
Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, Andrii Domanskyi, Riikka H. Hämäläinen, Gundars Goldsteins, Jari Koistinaho, Tarja Malm, Sweelin Chew, Kirsi Rilla, Anthony R. White, Nicholas Marsh-Armstrong, Katja M. Kanninen
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105753- (2022)
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is a
Externí odkaz:
https://doaj.org/article/90b3b33e12fd4d749b99c1ac7e4e3bbb
Autor:
Sara Nikseresht, James B.W. Hilton, Jeffrey R. Liddell, Kai Kysenius, Ashley I. Bush, Scott Ayton, HuiJing Koay, Paul S. Donnelly, Peter J. Crouch
Publikováno v:
Neuroscience. 509:125-131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6317b9381f76044f7b6e9ce61322c4c
https://doi.org/10.1016/j.neuroscience.2022.11.026
https://doi.org/10.1016/j.neuroscience.2022.11.026
Publikováno v:
Life, Vol 10, Iss 11, p 271 (2020)
The blood–brain barrier permeant, copper-containing compound, CuII(atsm), has successfully progressed from fundamental research outcomes in the laboratory through to phase 2/3 clinical assessment in patients with the highly aggressive and fatal neu
Externí odkaz:
https://doaj.org/article/330caf4af3d14b4f9571e91234705c4c
Autor:
Xin Yi Choo, Jeffrey R. Liddell, Mikko T. Huuskonen, Alexandra Grubman, Diane Moujalled, Jessica Roberts, Kai Kysenius, Lauren Patten, Hazel Quek, Lotta E. Oikari, Clare Duncan, Simon A. James, Lachlan E. McInnes, David J. Hayne, Paul S. Donnelly, Eveliina Pollari, Suvi Vähätalo, Katarína Lejavová, Mikko I. Kettunen, Tarja Malm, Jari Koistinaho, Anthony R. White, Katja M. Kanninen
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, including Alzheimer’s disease (AD). Inflammation and biometals are linked at the molecular level through regulation of me
Externí odkaz:
https://doaj.org/article/7883b0b3d158493f9964e1950be2d8dd
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Ferroptosis is a newly described form of regulated cell death, distinct from apoptosis, necroptosis and other forms of cell death. Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione peroxidase 4, exacerbated by
Externí odkaz:
https://doaj.org/article/d4add537cfc54d5f9e5a0cde51875d77
ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism
Autor:
Erin J. McAllum, Blaine R. Roberts, James L. Hickey, Theresa N. Dang, Alexandra Grubman, Paul S. Donnelly, Jeffrey R. Liddell, Anthony R. White, Peter J. Crouch
Publikováno v:
Neurobiology of Disease, Vol 81, Iss , Pp 20-24 (2015)
Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effective therapeutics do not yet exist. Transgenic rodent
Externí odkaz:
https://doaj.org/article/8a630bd39a6d430ca0378fa7f76817ec
Autor:
Sara, Nikseresht, James B W, Hilton, Jeffrey R, Liddell, Kai, Kysenius, Ashley I, Bush, Scott, Ayton, HuiJing, Koay, Paul S, Donnelly, Peter J, Crouch
Publikováno v:
Neuroscience. 509
Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9934a89c0e90ededfb88da815958e7c0
https://pubmed.ncbi.nlm.nih.gov/36436699
https://pubmed.ncbi.nlm.nih.gov/36436699
Autor:
Xin Yi Choo, Lachlan E. McInnes, Alexandra Grubman, Joanna M. Wasielewska, Irina Belaya, Emma Burrows, Hazel Quek, Jorge Cañas Martín, Sanna Loppi, Annika Sorvari, Dzhessi Rait, Andrew Powell, Clare Duncan, Jeffrey R. Liddell, Heikki Tanila, Jose M. Polo, Tarja Malm, Katja M. Kanninen, Paul S. Donnelly, Anthony R. White
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10722
Neuroinflammation has a major role in several brain disorders including Alzheimer’s disease (AD), yet at present there are no effective anti-neuroinflammatory therapeutics available. Copper(II) complexes of bis(thiosemicarbazones) (CuII(gtsm) and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c526429ef52637f396c9ca9b1ad233
https://pubmed.ncbi.nlm.nih.gov/36142627
https://pubmed.ncbi.nlm.nih.gov/36142627