Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jeffrey R Erickson"'
Autor:
Chidinma A Okolo, Ei-Phyo Khaing, Valeria Mereacre, Rachel S Wallace, Michelle L Munro, Jeffrey R Erickson, Peter P. Jones
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can tri
Externí odkaz:
https://doaj.org/article/9e686edc72f64357bd38a4f3c16f2c9c
Autor:
Jeffrey R Erickson
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Calcium/calmodulin (Ca2+/CaM) dependent protein kinase II (CaMKII) has emerged as a key nodal protein in the regulation of cardiac physiology and pathology. Due to the particularly elegant relationship between the structure and function of the kinase
Externí odkaz:
https://doaj.org/article/878f05da32f6413d8bf4f757b872b78d
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Increasing prevalence of diabetes mellitus worldwide has pushed the complex disease state to the foreground of biomedical research, especially concerning its multifaceted impacts on the cardiovascular system. Current therapies for diabetic cardiomyop
Externí odkaz:
https://doaj.org/article/488cd6ad52b846b9a79a72da0c5ff58d
Autor:
Claire L. Curl, Vennetia R. Danes, James R. Bell, Antonia J. A. Raaijmakers, Wendy T. K. Ip, Chanchal Chandramouli, Tristan W. Harding, Enzo R. Porrello, Jeffrey R. Erickson, Fadi J. Charchar, Andrew R. Kompa, Amanda J. Edgley, David J. Crossman, Christian Soeller, Kimberley M. Mellor, Jonathan M. Kalman, Stephen B. Harrap, Lea M. D. Delbridge
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 11 (2018)
BackgroundAmong the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need—and the l
Externí odkaz:
https://doaj.org/article/1d494628ead14a7dbee011a799b45a35
Autor:
Finn T. Roberts-Craig, Luke P. Worthington, Samuel P. O’Hara, Jeffrey R. Erickson, Alison K. Heather, Zoe Ashley
Publikováno v:
International journal of molecular sciences. 23(14)
Vascular smooth muscle cells (VSMCs) help to maintain the normal physiological contractility of arterial vessels to control blood pressure; they can also contribute to vascular disease such as atherosclerosis. Ca2+/calmodulin-dependent kinase II (CaM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aedb651fbfcc72127e45b53a555f42
https://pubmed.ncbi.nlm.nih.gov/35887264
https://pubmed.ncbi.nlm.nih.gov/35887264
Autor:
Angela C. Greenman, Gary M. Diffee, Amelia S. Power, Gerard T. Wilkins, Olivia M. S. Gold, Jeffrey R. Erickson, James C. Baldi
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 132(6)
The cardiovascular benefits of regular exercise are unequivocal, yet patients with type 2 diabetes respond poorly to exercise due to a reduced cardiac reserve. The contractile response of diabetic cardiomyocytes to β-adrenergic stimulation is attenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5acabcef55765dd4817660c784bb12
https://pubmed.ncbi.nlm.nih.gov/35482324
https://pubmed.ncbi.nlm.nih.gov/35482324
Publikováno v:
Nitric oxide : biology and chemistry. 129
Nitric oxide (NO) is a key vasodilatory signalling molecule and NO releasing molecules (NO donors) are being examined as potential treatments for many pathologies. The photoresponsive NO donor tert-dodecane S-nitrosothiol (tDodSNO) has been designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61db0cdfb77bb1b04aa0166c50a7ab7
https://pubmed.ncbi.nlm.nih.gov/36209988
https://pubmed.ncbi.nlm.nih.gov/36209988
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Increasing prevalence of diabetes mellitus worldwide has pushed the complex disease state to the foreground of biomedical research, especially concerning its multifaceted impacts on the cardiovascular system. Current therapies for diabetic cardiomyop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9a8c149c2e29122c04980e9c2abdc8
https://doi.org/10.3389/fphar.2021.695401
https://doi.org/10.3389/fphar.2021.695401
Publikováno v:
Heart Rhythm. 16:765-772
Background Type 2 diabetes (T2D) increases arrhythmia risk through incompletely elucidated mechanisms. Ventricular arrhythmias could be initiated by delayed afterdepolarizations (DADs) resulting from elevated spontaneous sarcoplasmic reticulum (SR) C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892e0e274ee13fda5ca78243980b85d7
https://doi.org/10.1016/j.hrthm.2018.11.001
https://doi.org/10.1016/j.hrthm.2018.11.001
Publikováno v:
Acta Physiologica. 233
O-GlcNAcylation is a ubiquitous post-translational modification that is extremely labile and plays a significant role in physiology, including the heart. Sustained activation of cardiac O-GlcNAcylation is frequently associated with alterations in cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463dbaea4ec5e547861084c8a61c8036
https://doi.org/10.1111/apha.13696
https://doi.org/10.1111/apha.13696