Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jeffrey R, van Senten"'
Autor:
Maarten P. Bebelman, Irfan M. Setiawan, Nick D. Bergkamp, Jeffrey R. van Senten, Caitrin Crudden, Jan Paul M. Bebelman, Frederik J. Verweij, Guillaume van Niel, Marco Siderius, D. Michiel Pegtel, Martine J. Smit
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107412- (2023)
Summary: The human cytomegalovirus (HCMV)-encoded chemokine receptor US28 contributes to various aspects of the viral life cycle and promotes immune evasion by scavenging chemokines from the microenvironment of HCMV-infected cells. In contrast to the
Externí odkaz:
https://doaj.org/article/3584ed7d87864108bd8d9bb36453dd90
Autor:
Jeffrey R. van Senten, Maarten P. Bebelman, Puck van Gasselt, Nick D. Bergkamp, Jelle van den Bor, Marco Siderius, Martine J. Smit
Publikováno v:
Viruses, Vol 12, Iss 6, p 594 (2020)
Human cytomegalovirus (HCMV) encodes four G protein-coupled receptor (GPCR) homologs. Three of these receptors, UL78, US27 and US28, are known for their roles in HCMV dissemination and latency. Despite importance of its rodent orthologs for viral rep
Externí odkaz:
https://doaj.org/article/e4a963461fdd4c739bcf41c8084bd0f7
Publikováno v:
Moo, E V, Van Senten, J R, Bräuner-osborne, H & Møller, T C 2021, ' Arrestin-Dependent and-Independent Internalization of G Protein–Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling ', Molecular Pharmacology, vol. 99, no. 4, pp. 242-255 . https://doi.org/10.1124/molpharm.120.000192
Molecular Pharmacology
Molecular Pharmacology
Agonist-induced endocytosis is a key regulatory mechanism for controlling the responsiveness of the cell by changing the density of cell surface receptors. In addition to the role of endocytosis in signal termination, endocytosed G protein-coupled re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaa541237585bec4578b1181c1dcbc8
https://doi.org/10.1124/molpharm.120.000192
https://doi.org/10.1124/molpharm.120.000192
Publikováno v:
The Journal of biological chemistry. 298(10)
The internalization of G protein-coupled receptors (GPCRs) can be regulated by PKC. However, most tools available to study the contribution of PKC isozymes have considerable limitations, including a lack of selectivity. In this study, we generated an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37c6fabe3005ac52426425b58f23519a
https://pubmed.ncbi.nlm.nih.gov/36087841
https://pubmed.ncbi.nlm.nih.gov/36087841
Publikováno v:
van Senten, J R, Fan, T S, Siderius, M & Smit, M J 2020, ' Viral G protein-coupled receptors as modulators of cancer hallmarks ', Pharmacological Research, vol. 156, 104804, pp. 1-13 . https://doi.org/10.1016/j.phrs.2020.104804
Herpesviruses encode transmembrane G protein-coupled receptors (GPCRs), which share structural homology to human chemokine receptors. These viral GPCRs include KSHV-encoded ORF74, EBV-encoded BILF1, and HCMV-encoded US28, UL33, UL78 and US27. Viral G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d78ba69e3004546734bf2d5ba54b9e
https://hdl.handle.net/1871.1/13febc04-d0f6-47e0-9c08-b15aef4cfe63
https://hdl.handle.net/1871.1/13febc04-d0f6-47e0-9c08-b15aef4cfe63
Autor:
Tian Shu Fan, Timo W.M. De Groof, Diane Van Hoorick, Henry F. Vischer, Maarten P. Bebelman, Laura Smits-de Vries, Afsar Rahbar, Marco Siderius, Jeffrey R. van Senten, Tonny Lagerweij, Raimond Heukers, Jody van Offenbeek, Raymond H. de Wit, Thomas Wurdinger, Rob Leurs, Cecilia Söderberg-Nauclér, Joao Vieira, Martine J. Smit, Sabrina M. de Munnik
Publikováno v:
Oncogene
Oncogene, 37(30), 4110-4121. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 37, no. 30, pp. 4110-4121 . https://doi.org/10.1038/s41388-018-0255-7
Oncogene, 2018(30), 1-12. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 2018, no. 30, pp. 1-12 . https://doi.org/10.1038/s41388-018-0255-7
Oncogene, 37(30), 4110-4121. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 37, no. 30, pp. 4110-4121 . https://doi.org/10.1038/s41388-018-0255-7
Oncogene, 2018(30), 1-12. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 2018, no. 30, pp. 1-12 . https://doi.org/10.1038/s41388-018-0255-7
Glioblastoma (GBM) is the most aggressive and an incurable type of brain cancer. Human cytomegalovirus (HCMV) DNA and encoded proteins, including the chemokine receptor US28, have been detected in GBM tumors. US28 displays constitutive activity and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d2b143f496bc5734d97f476890189d
http://europepmc.org/articles/PMC6062493
http://europepmc.org/articles/PMC6062493
Autor:
Jesper Mosolff Mathiesen, Sofie D. Seiersen, Jeffrey R. van Senten, Mie Fabricius Pedersen, Hans Bräuner-Osborne, Michel Bouvier, Thor C. Møller
Publikováno v:
Møller, T C, Pedersen, M F, van Senten, J R, Seiersen, S D, Mathiesen, J M, Bouvier, M & Bräuner-Osborne, H 2020, ' Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells ', Scientific Reports, vol. 10, no. 1, 17395 . https://doi.org/10.1038/s41598-020-73674-0
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Most G protein-coupled receptors (GPCRs) recruit β-arrestins and internalize upon agonist stimulation. For the μ-opioid receptor (μ-OR), this process has been linked to development of opioid tolerance. GPCR kinases (GRKs), particularly GRK2 and GR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97ca6d627bac5187dc196269597fae4
https://curis.ku.dk/ws/files/251408173/OA_Dissecting_the_roles_ofGRK2.pdf
https://curis.ku.dk/ws/files/251408173/OA_Dissecting_the_roles_ofGRK2.pdf
Autor:
Puck van Gasselt, David Maussang, René J. P. Musters, Erik Slinger, Guus A.M.S. van Dongen, Ellen Langemeijer, Cecilia Söderberg-Nauclér, Jeffrey R. van Senten, Tonny Lagerweij, Marijke Stigter-van Walsum, Raimond Heukers, Marco Siderius, Martine J. Smit, Thomas Wurdinger, Rob Leurs, Tian Shu Fan, Afsar Rahbar, Nick D. Bergkamp, Maarten P. Bebelman
Publikováno v:
Journal of Biological Chemistry, 294(44), 16297-16308. American Society for Biochemistry and Molecular Biology Inc.
J Biol Chem
Van Senten, J R, Bebelman, M P, Fan, T S, Heukers, R, Bergkamp, N D, Van Gasselt, P, Langemeijer, E V, Slinger, E, Lagerweij, T, Rahbar, A, Van Walsum, M S, Maussang, D, Leurs, R, Musters, R J P, Van Dongen, G A M S, Söderberg-Nauclér, C, Würdinger, T, Siderius, M & Smit, M J 2019, ' The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties ', Journal of Biological Chemistry, vol. 294, no. 44, pp. 16297-16308 . https://doi.org/10.1074/jbc.RA119.007796, https://doi.org/10.1074/jbc.RA119.007796
Van Senten, J R, Bebelman, M P, Fan, T S, Heukers, R, Bergkamp, N D, Van Gasselt, P, Langemeijer, E V, Slinger, E, Lagerweij, T, Rahbar, A, Van Walsum, M S, Maussang, D, Leurs, R, Musters, R J P, Van Dongen, G A M S, Söderberg-Nauclér, C, Würdinger, T, Siderius, M & Smit, M J 2019, ' The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties ', Journal of Biological Chemistry, vol. 294, no. 44, pp. 16297-16308 . https://doi.org/10.1074/jbc.RA119.007796
J Biol Chem
Van Senten, J R, Bebelman, M P, Fan, T S, Heukers, R, Bergkamp, N D, Van Gasselt, P, Langemeijer, E V, Slinger, E, Lagerweij, T, Rahbar, A, Van Walsum, M S, Maussang, D, Leurs, R, Musters, R J P, Van Dongen, G A M S, Söderberg-Nauclér, C, Würdinger, T, Siderius, M & Smit, M J 2019, ' The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties ', Journal of Biological Chemistry, vol. 294, no. 44, pp. 16297-16308 . https://doi.org/10.1074/jbc.RA119.007796, https://doi.org/10.1074/jbc.RA119.007796
Van Senten, J R, Bebelman, M P, Fan, T S, Heukers, R, Bergkamp, N D, Van Gasselt, P, Langemeijer, E V, Slinger, E, Lagerweij, T, Rahbar, A, Van Walsum, M S, Maussang, D, Leurs, R, Musters, R J P, Van Dongen, G A M S, Söderberg-Nauclér, C, Würdinger, T, Siderius, M & Smit, M J 2019, ' The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties ', Journal of Biological Chemistry, vol. 294, no. 44, pp. 16297-16308 . https://doi.org/10.1074/jbc.RA119.007796
Herpesviruses can rewire cellular signaling in host cells by expressing viral G protein- coupled receptors (GPCRs). These viral receptors exhibit homology to human chemokine receptors, but some display constitutive activity and promiscuous G protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c11cbb8219b78ca20315c799bdc2bd
https://research.vu.nl/en/publications/ce81ac21-3e7d-453f-a60b-0117b02a0b39
https://research.vu.nl/en/publications/ce81ac21-3e7d-453f-a60b-0117b02a0b39
Autor:
Martine J. Smit, Jeffrey R. van Senten, Marco Siderius, Alberto Fraile-Ramos, Azra Mujić-Delić, Raymond H. de Wit
Publikováno v:
de Wit, R H, Mujic-Delic, A, van Senten, J R, Fraile-Ramos, A, Siderius, M H & Smit, M J 2016, ' Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1 alpha/PKM2 axis in glioblastoma cells. ', Oncotarget, vol. Sept 1, 11817 . https://doi.org/10.18632/oncotarget.11817
Oncotarget
Oncotarget, Sept 1:11817. Impact Journals
Oncotarget
Oncotarget, Sept 1:11817. Impact Journals
// Raymond H. de Wit 1,* , Azra Mujic-Delic 1,* , Jeffrey R. van Senten 1 , Alberto Fraile-Ramos 2 , Marco Siderius 1 and Martine J. Smit 1 1 Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9495a055a05c4eb8e4d02448cefc2e70
https://doi.org/10.18632/oncotarget.11817
https://doi.org/10.18632/oncotarget.11817
Autor:
Martine J. Smit, Marco Siderius, Jeffrey R. van Senten, Puck van Gasselt, Maarten P. Bebelman, Nick D. Bergkamp, Jelle van den Bor
Publikováno v:
Viruses
Viruses, 12(6):594, 1-11. MDPI
van Senten, J R, Bebelman, M P, van Gasselt, P, Bergkamp, N D, van den Bor, J, Siderius, M & Smit, M J 2020, ' Human cytomegalovirus-encoded G protein-coupled receptor UL33 facilitates virus dissemination via the extracellular and cell-to-cell route ', Viruses, vol. 12, no. 6, 594, pp. 1-11 . https://doi.org/10.3390/v12060594
Viruses, Vol 12, Iss 594, p 594 (2020)
Volume 12
Issue 6
Viruses, 12(6):594, 1-11. MDPI
van Senten, J R, Bebelman, M P, van Gasselt, P, Bergkamp, N D, van den Bor, J, Siderius, M & Smit, M J 2020, ' Human cytomegalovirus-encoded G protein-coupled receptor UL33 facilitates virus dissemination via the extracellular and cell-to-cell route ', Viruses, vol. 12, no. 6, 594, pp. 1-11 . https://doi.org/10.3390/v12060594
Viruses, Vol 12, Iss 594, p 594 (2020)
Volume 12
Issue 6
Human cytomegalovirus (HCMV) encodes four G protein-coupled receptor (GPCR) homologs. Three of these receptors, UL78, US27 and US28, are known for their roles in HCMV dissemination and latency. Despite importance of its rodent orthologs for viral rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1074c991bacf607876b04a7d6ab6fe90
https://doi.org/10.3390/v12060594
https://doi.org/10.3390/v12060594