84 Using Opportunistic Sampling and Remnant Blood Samples to Develop Pediatric Pharmacokinetic Models to Inform Antidepressant Dosing

Autor: Jeffrey R. Strawn, Ethan A. Poweleit, Zachary L. Taylor, Tomoyuki Mizuno, Samuel Vaughn, Zeruesenay Desta, Stephani Stancil, Laura B. Ramsey

Publikováno v: Journal of Clinical and Translational Science, Vol 8, Pp 22-23 (2024)

OBJECTIVES/GOALS: Developing pharmacokinetic (PK) models to guide selective serotonin reuptake inhibitor (SSRI) dosing in youth is costly, time-intensive, and requires large numbers of participants. We evaluated the use of remnant blood samples from

Externí odkaz: https://doaj.org/article/e1d8503c9362423ea58b12fa2f44074f

Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group

Autor: Anita Harrewijn, Elise M. Cardinale, Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Moji Aghajani, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Savannah Gosnell, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, Karina S. Blair, James R. Blair, Mira Z. Hammoud, Mohammed R. Milad, Katie L. Burkhouse, K. Luan Phan, Heidi K. Schroeder, Jeffrey R. Strawn, Katja Beesdo-Baum, Neda Jahanshad, Sophia I. Thomopoulos, Randy Buckner, Jared A. Nielsen, Jordan W. Smoller, Jair C. Soares, Benson Mwangi, Mon-Ju Wu, Giovana B. Zunta-Soares, Michal Assaf, Gretchen J. Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca B. Price, Gisele G. Manfro, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza Jovanovic, Bianca A. V. Alberton, Brenda Benson, Gabrielle F. Freitag, Courtney A. Filippi, Andrea L. Gold, Ellen Leibenluft, Grace V. Ringlein, Kathryn E. Werwath, Hannah Zwiebel, André Zugman, Hans J. Grabe, Sandra Van der Auwera, Katharina Wittfeld, Henry Völzke, Robin Bülow, Nicholas L. Balderston, Monique Ernst, Christian Grillon, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Hugo D. Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Murray B. Stein, Raquel E. Gur, Ruben C. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Jennifer Harper, Michael Myers, Michael T. Perino, Chad M. Sylvester, Qiongru Yu, Ulrike Lueken, Dick J. Veltman, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee, Anderson M. Winkler, Daniel S. Pine

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/an

Externí odkaz: https://doaj.org/article/9d17f9f8582240abad7553d20434e213

Pediatric anxiety and daily fine particulate matter: A longitudinal study

Autor: Andrew Vancil, Jeffrey R. Strawn, Erika Rasnick, Amir Levine, Heidi K. Schroeder, Ashley M. Specht, Ashley L. Turner, Patrick H. Ryan, Cole Brokamp

Publikováno v: Psychiatry Research Communications, Vol 2, Iss 4, Pp 100077- (2022)

Daily variations in ambient fine particulate matter (PM2.5) could contribute to the morbidity of anxiety disorders in children and adolescents, but has not yet been studied longitudinally at a daily level. We tested this association using repeated we

Externí odkaz: https://doaj.org/article/7cffd4a2919f4fa1817e6cec78a6eb89

Neurocircuitry of treatment in anxiety disorders

Autor: W. Tommy Baumel, Lu Lu, Xiaoqi Huang, Andrew T. Drysdale, John A. Sweeny, Qiyong Gong, Chad M. Sylvester, Jeffrey R. Strawn

Publikováno v: Biomarkers in Neuropsychiatry, Vol 6, Iss , Pp 100052- (2022)

Background: Understanding how treatments change neurobiology is critical to developing predictors of treatment response. This is especially true for anxiety disorders—the most common psychiatric disorders across the lifespan. With this in mind, we

Externí odkaz: https://doaj.org/article/d9b983f957d6402e87dbe078360f355d

Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study

Autor: Fabiano G. Nery, Anna R. Wilson, Marguerite R. Schneider, Jeffrey R. Strawn, Luis R. Patino, Robert K. McNamara, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello

Publikováno v: Brazilian Journal of Psychiatry, Vol 42, Iss 5, Pp 481-488 (2020)

Objectives: To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder. Methods: Youth aged 9-20 ye

Externí odkaz: https://doaj.org/article/c154f513396f4b2c914f750056dabe2c