Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeffrey Peter Mitchell"'
Autor:
Ram Yogev, Barrie Harper, Jeffrey Peter Mitchell, Daniel Gonzalez, Susan R. Mendley, Andrew M. Atz, Julie Autmizguine, Janice E. Sullivan, Andrew Lewandowski, Paula Delmore, Brenda B. Poindexter, Michael Cohen-Wolkowiez, Chiara Melloni, Christoph P. Hornik, Samantha H Dallefeld, Amira Al-Uzri
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Trimethoprim (TMP)-sulfamethoxazole (SMX) is used to treat various types of infections, including community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) and Pneumocystis jirovecii infections in children. Pharmacokinetic (PK) data fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852b9bec0565aa27465e740415e34be0
https://doi.org/10.1128/aac.01813-17
https://doi.org/10.1128/aac.01813-17
Autor:
Angela Luttick, Jennifer E. Fenner, Simon P. Tucker, Jeffrey Peter Mitchell, Chin Yu Lim, Bo Lin, Roland Henry Nearn, Silas Bond, Penelope Anne Mayes, John N. Lambert, Craig J. Morton, Vanessa Anne Sanford, Kelly Helen Anderson, Alistair George Draffan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:976-981
Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children and adults. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones with general structure 1 were previously identified as promising inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951c6b9135483c44ae7ba24e4c56e919
https://doi.org/10.1016/j.bmcl.2014.11.024
https://doi.org/10.1016/j.bmcl.2014.11.024
Autor:
Samantha H Dallefeld, Jeffrey Peter Mitchell, Ram Yogev, Barrie Harper, Matthew M. Laughon, Christoph P. Hornik, Janice E. Sullivan, Susan R. Mendley, Huali Wu, Chiara Melloni, Michael Cohen-Wolkowiez, Thomas P. Green, Andrew Lewandowski, Amira Al-Uzri, Andrew M. Atz
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 45(3)
Amiodarone is a first-line antiarrhythmic for life-threatening ventricular fibrillation or ventricular tachycardia in children, yet little is known about its pharmacokinetics (PK) in this population. We developed a population PK (PopPK) model using s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1864cf947e7805e1db41e0b805db13d
https://pubmed.ncbi.nlm.nih.gov/29435949
https://pubmed.ncbi.nlm.nih.gov/29435949
Autor:
Ian Collins, Pramod K. Chauhan, Neil R. Stokes, Anu Mahajan, Anil K Srivastava, Mahipal Singh, Anju Yadav, James M. Bennett, Leanne MacLeod, Paul Lancett, Yashodanand Nandan Nayal, David T. Davies, Narendra Nayal, Maruti Gavade, David J. Haydon, Rebecca Macdonald, Nicola Baker, Jeffrey Peter Mitchell, Lloyd George Czaplewski, Pitt Gary Robert William, Dushyant Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:353-359
The design, synthesis and structure-activity relationships of a series of oxazole-benzamide inhibitors of the essential bacterial cell division protein FtsZ are described. Compounds had potent anti-staphylococcal activity and inhibited the cytokinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddbd9a97bd9de9b500efee80df242b4
https://doi.org/10.1016/j.bmcl.2013.11.002
https://doi.org/10.1016/j.bmcl.2013.11.002
Autor:
Jeffrey Peter Mitchell, David J. Haydon, Hilary Peasley, Lloyd George Czaplewski, Narendra Nayal, Alastair Logan, Joanne Berry, Anil K. Srivastava, Anju Yadav, Ian Collins, Neil R. Stokes, James M. Bennett, Rebecca Macdonald, Nicola Baker, Leanne MacLeod
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:317-325
The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have been reported to be potent and selective antistaphylococcal agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9b083bc874958b03fddf8bb95cf0f
https://doi.org/10.1128/aac.01580-12
https://doi.org/10.1128/aac.01580-12
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :471-484
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2cd19222dd31f42946e22ff6f49970d
https://doi.org/10.1039/b001942i
https://doi.org/10.1039/b001942i
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089cf692eb363342806dafbf27073d6a
https://doi.org/10.1002/chin.200131244
https://doi.org/10.1002/chin.200131244
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(19)
Two new methods for the modification of PAMAM dendrimers have been developed which allow the covergent synthesis of either peptide or carbohydrate-bearing dendrimer molecules. Both methods involve condensation between hydroxylamino nucleophiles and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a9d329a8451d2d9414079ad4456410
https://pubmed.ncbi.nlm.nih.gov/10522691
https://pubmed.ncbi.nlm.nih.gov/10522691