Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jeffrey Pangilinan"'
Autor:
Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscl
Externí odkaz:
https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d9
Autor:
Jason Mastaitis, Andrew J. Murphy, Jesus A. Trejos, Stephen Jaspers, Jeffrey Pangilinan, Trevor Stitt, Erqian Na, Esther Latres, Yu Bai, George D. Yancopoulos, Lawrence Miloscio, Jesper Gromada, Ashique Rafique, Wen Fury, Jee Hae Kim, Tobias Willer, Katie Cavino, Haruka Okamoto, Angelos Papatheodorou
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man. Broad T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87739244226941d93603a7a609426820
https://doi.org/10.1038/ncomms15153
https://doi.org/10.1038/ncomms15153
Autor:
Calvin Lin, George D. Yancopoulos, Trevor Stitt, Erqian Na, Terra Potocky, Andrew J. Murphy, Roy Bauerlein, Ying Huang, Jesper Gromada, Jeffrey Pangilinan, Ashique Rafique, Lawrence Miloscio, Mark Eckersdorff, Jason Mastaitis, Esther Latres
Publikováno v:
Skeletal Muscle
Background Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported the concept that inactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74fe5eeba57ddc6f17d3abd6ce4487a
https://doi.org/10.1186/s13395-015-0060-8
https://doi.org/10.1186/s13395-015-0060-8