Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jeffrey P. Spence"'
Autor:
Jacob Schreiber, Carles Boix, Jin wook Lee, Hongyang Li, Yuanfang Guan, Chun-Chieh Chang, Jen-Chien Chang, Alex Hawkins-Hooker, Bernhard Schölkopf, Gabriele Schweikert, Mateo Rojas Carulla, Arif Canakoglu, Francesco Guzzo, Luca Nanni, Marco Masseroli, Mark James Carman, Pietro Pinoli, Chenyang Hong, Kevin Y. Yip, Jeffrey P. Spence, Sanjit Singh Batra, Yun S. Song, Shaun Mahony, Zheng Zhang, Wuwei Tan, Yang Shen, Yuanfei Sun, Minyi Shi, Jessika Adrian, Richard Sandstrom, Nina Farrell, Jessica Halow, Kristen Lee, Lixia Jiang, Xinqiong Yang, Charles Epstein, J. Seth Strattan, Bradley Bernstein, Michael Snyder, Manolis Kellis, William Stafford, Anshul Kundaje, ENCODE Imputation Challenge Participants
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational methods to impute the remainder. However, identifying the best imputation methods and what measu
Externí odkaz:
https://doaj.org/article/af322f5b401248609628ec2ad86cadd9
Autor:
Sandra Bond Chapman, Julie M. Fratantoni, Ian H. Robertson, Mark D'Esposito, Geoffrey S. F. Ling, Jennifer Zientz, Stacy Vernon, Erin Venza, Lori G. Cook, Aaron Tate, Jeffrey S. Spence
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Introduction: Brain health is neglected in public health, receiving attention after something goes wrong. Neuroplasticity research illustrates that preventive steps strengthen the brain's component systems; however, this information is not widely kno
Externí odkaz:
https://doaj.org/article/263840064a7e478686f19a344ee1200a
Autor:
Bambi L. DeLaRosa, Jeffrey S. Spence, Michael A. Motes, Wing To, Sven Vanneste, Michael A. Kraut, John Hart Jr
Publikováno v:
Brain and Behavior, Vol 10, Iss 12, Pp n/a-n/a (2020)
Abstract Introduction Prior Go/NoGo studies have localized specific regions and EEG spectra for which traditional approaches have distinguished between Go and NoGo conditions. A more detailed characterization of the spatial distribution and timing of
Externí odkaz:
https://doaj.org/article/fabac393372047708ad12555b53a607f
Autor:
Moises Exposito-Alonso, Tom R. Booker, Lucas Czech, Lauren Gillespie, Shannon Hateley, Christopher C. Kyriazis, Patricia L. M. Lang, Laura Leventhal, David Nogues-Bravo, Veronica Pagowski, Megan Ruffley, Jeffrey P. Spence, Sebastian E. Toro Arana, Clemens L. Weiß, Erin Zess
Publikováno v:
Exposito-Alonso, M, Booker, T R, Czech, L, Gillespie, L, Hateley, S, Kyriazis, C C, Lang, P L M, Leventhal, L, Nogues-Bravo, D, Pagowski, V, Ruffley, M, Spence, J P, Arana, S E T, Weiss, C L & Zess, E 2022, ' Genetic diversity loss in the Anthropocene ', Science, vol. 377, no. 6613, pp. 1431-1435 . https://doi.org/10.1126/science.abn5642
More species than ever before are at risk of extinction due to anthropogenic habitat loss and climate change. But even species that are not threatened have seen reductions in their populations and geographic ranges, likely impacting their genetic div
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
BackgroundThe human brain has high energy requirements that continuously support healthy neuronal activity and cognition. A disruption in brain energy metabolism (BEM) may contribute to early neuropathological changes such as accumulation of β-amylo
Externí odkaz:
https://doaj.org/article/c35fe06d7c0c40c0be7f9b5cefa6dc5a
Autor:
Dinesh K. Sivakolundu, Kathryn L. West, Mark Zuppichini, Monroe P. Turner, Dema Abdelkarim, Yuguang Zhao, Jeffrey S. Spence, Hanzhang Lu, Darin T. Okuda, Bart Rypma
Publikováno v:
NeuroImage, Vol 215, Iss , Pp 116812- (2020)
Behavioral studies investigating fundamental cognitive abilities provide evidence that processing speed accounts for large proportions of performance variability between individuals. Processing speed decline is a hallmark feature of the cognitive dis
Externí odkaz:
https://doaj.org/article/e23162d2cf094d9b90d9dcd554ae89d9
Autor:
Preetam Schramm, Namrata Das, Emet Schneiderman, Zohre German, Jason Hui, Duane Wilson, Jeffrey S. Spence, Pollyana Moura, Sandra B. Chapman
Publikováno v:
Geriatrics, Vol 6, Iss 4, p 107 (2021)
Respiration rate (RR) dynamics entrains brain neural networks. RR differences between mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to oral appliance therapy (OAT) are unknown. This pilot study investigated if RR during s
Externí odkaz:
https://doaj.org/article/15fcccdc80934b65af1c206e24697c6f
Autor:
Roshni A. Patel, Shaila A. Musharoff, Jeffrey P. Spence, Harold Pimentel, Catherine Tcheandjieu, Hakhamanesh Mostafavi, Nasa Sinnott-Armstrong, Shoa L. Clarke, Courtney J. Smith, Peter P. Durda, Kent D. Taylor, Russell Tracy, Yongmei Liu, W. Craig Johnson, Francois Aguet, Kristin G. Ardlie, Stacey Gabriel, Josh Smith, Deborah A. Nickerson, Stephen S. Rich, Jerome I. Rotter, Philip S. Tsao, Themistocles L. Assimes, Jonathan K. Pritchard
Publikováno v:
Am J Hum Genet
Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has
Publikováno v:
bioRxiv
The Discrete-Time Wright Fisher (DTWF) model and its large population diffusion limit are central to population genetics. These models describe the forward-in-time evolution of the frequency of an allele in a population and can include the fundamenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ef3152fb2df13b272e080d09c171be
https://doi.org/10.1101/2023.05.19.541517
https://doi.org/10.1101/2023.05.19.541517
Publikováno v:
bioRxiv
Measures of selective constraint on genes have been used for many applications including clinical interpretation of rare coding variants, disease gene discovery, and studies of genome evolution. However, widely-used metrics are severely underpowered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa6056fedd4ea44f61000c6339bd4b9
https://europepmc.org/articles/PMC10245655/
https://europepmc.org/articles/PMC10245655/