Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jeffrey P. Bruce"'
Autor:
Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, S. Y. Cindy Yang, David T. Mulder, Jeffrey P. Bruce, Joseph N. Paulson, Pichai Raman, Yuankun Zhu, Adam C. Resnick, Poul H. Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D. Johann, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Natalie Jäger, Trevor J. Pugh
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for pa
Externí odkaz:
https://doaj.org/article/55f18503cc5b446bb5969c8df01fb686
Autor:
Caitlin T. Fierheller, Laure Guitton-Sert, Wejdan M. Alenezi, Timothée Revil, Kathleen K. Oros, Yuandi Gao, Karine Bedard, Suzanna L. Arcand, Corinne Serruya, Supriya Behl, Liliane Meunier, Hubert Fleury, Eleanor Fewings, Deepak N. Subramanian, Javad Nadaf, Jeffrey P. Bruce, Rachel Bell, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Jacek Majewski, Trevor J. Pugh, Marc Tischkowitz, Paul A. James, Ian G. Campbell, Celia M. T. Greenwood, Jiannis Ragoussis, Jean-Yves Masson, Patricia N. Tonin
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-26 (2021)
Abstract Background Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA r
Externí odkaz:
https://doaj.org/article/52b67832911d434ca9c1266c56a3622d
Autor:
S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 c
Externí odkaz:
https://doaj.org/article/2a55653c8f4a4ed888f461e4bdb5696f
Autor:
Jennifer Yin Yee Kwan, Liang-Tzung Lin, Rachel Bell, Jeffrey P. Bruce, Christopher Richardson, Trevor J. Pugh, Fei-Fei Liu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Multiple studies have reported a doubling in risk of Coronavirus Disease-2019 (COVID-19) among cancer patients. Here, we examine the potential biological rationale behind this recurrent epidemiological observation. By leveraging large-scale
Externí odkaz:
https://doaj.org/article/5b5d721bd98047939c6e665fc34c1be2
Autor:
Caitlin T. Fierheller, Wejdan M. Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N. Subramanian, Eleanor Fewings, Jeffrey P. Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G. Campbell, Trevor J. Pugh, Celia M. T. Greenwood, Jiannis Ragoussis, Patricia N. Tonin
Publikováno v:
Genes, Vol 14, Iss 2, p 277 (2023)
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular genetic characteristics of FANCI, as
Externí odkaz:
https://doaj.org/article/760e9117f65c4e71ac2573e2329fbc39
Autor:
David Goldstein, Anna Spreafico, Ilan Weinreb, Trevor J. Pugh, Scott V Bratman, Bayardo Perez-Ordonez, Aaron R Hansen, Lillian Siu, Antony Tin, Alexey Aleshin, Amy Prawira, Jonathan Irish, John de Almeida, Douglas Chepeha, Stephen Smith, Marc Oliva, Daniel V Araujo, J. Javier Diaz-Mejia, Peter Olson, Tina Shek, Andrew Hope, Dax Torti, Jeffrey P. Bruce, Ben X. Wang, Anthony Fortuna, Hirak Der-Torossian, Ronald Shazer, Nickolas Attanasio, Qingyan Au, Jordan Feeney, Himanshu Sethi, Isan Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/0c91b22ec6d04b31bb0d153a425dbaed
Autor:
Chetan Safi, Daniel Spielman, Marc Otten, Jeffrey N. Bruce, Neil Feldstein, Jonathan B. Overdevest, David A. Gudis
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Introduction: Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a small round blue cell tumor of nasal neuroepithelium first described in 1924. Though this tumor is especially rare in the pediatric population with an incidence of
Externí odkaz:
https://doaj.org/article/859e4961bb744f3ba7c68ff595b0e7fd
Autor:
Jinzhou Yuan, Hanna Mendes Levitin, Veronique Frattini, Erin C. Bush, Deborah M. Boyett, Jorge Samanamud, Michele Ceccarelli, Athanassios Dovas, George Zanazzi, Peter Canoll, Jeffrey N. Bruce, Anna Lasorella, Antonio Iavarone, Peter A. Sims
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-15 (2018)
Abstract Background Despite extensive molecular characterization, we lack a comprehensive understanding of lineage identity, differentiation, and proliferation in high-grade gliomas (HGGs). Methods We sampled the cellular milieu of HGGs by profiling
Externí odkaz:
https://doaj.org/article/6be843e71c994480a656cf91533de3d3
Autor:
Cheng-Hung Tai, Cheng-Chia Wu, Mark E Hwang, Anurag Saraf, Christopher Grubb, Ashish Jani, Matthew E Lapa, Jacquelyn I S Andrews, Steven R Isaacson, Adam M Sonabend, Sameer A Sheth, Guy M McKhann, Michael B Sisti, Jeffrey N Bruce, Simon K Cheng, Eileen P Connolly, Tony JC Wang
Publikováno v:
CNS Oncology, Vol 7, Iss 1, Pp 25-34 (2018)
Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & methods: We retrospectively gathered data from 127 breast cancer patients who u
Externí odkaz:
https://doaj.org/article/98760b8a48174ab3a28e68a83cbe0ea2
Autor:
Amit M. Oza, Trevor J. Pugh, Zhihui (Amy) Liu, Yeh Chen Lee, Lorena Fariñas-Madrid, Tiantiam Li, Stephanie Pedersen, Iulia Cirlan, Katherine Karakasis, Marsela Braunstein, Qian Tan, Sarah Accardi, Justin White, Valerie Bowering, Neesha C. Dhani, Ainhoa Madariaga, Jeffrey P. Bruce, Swati Garg, Ana Oaknin, Stephanie Lheureux
Purpose:PARP inhibitors (PARPi) are standard-of-care therapy for high-grade serous ovarian cancer (HGSOC). We investigated combining cediranib (antiangiogenic) with olaparib (PARPi) at emergence of PARPi resistance.Patients and Methods:The proof-of-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6b12c6b527a49a4e3a78faae4c695b
https://doi.org/10.1158/1078-0432.c.6529832.v1
https://doi.org/10.1158/1078-0432.c.6529832.v1