Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jeffrey P Murry"'
Autor:
R Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D Sloan, Dan Karel, Hing C Wong, Emily K Jeng, Allison S Thomas, James B Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A Ostrowski, Darrell J Irvine, Bruce D Walker
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005545 (2016)
Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently c
Externí odkaz:
https://doaj.org/article/8d9eef0385234f16ae9fba721f3491fb
Autor:
Cressida A Madigan, Amanda Jezek Martinot, Jun-Rong Wei, Ashoka Madduri, Tan-Yun Cheng, David C Young, Emilie Layre, Jeffrey P Murry, Eric J Rubin, D Branch Moody
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004792 (2015)
The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme iron using mycobactin and carboxymycobactin siderophores, synthesized by myco
Externí odkaz:
https://doaj.org/article/e42074d0df95400da6d67ff886ee2b4a
Autor:
Derek D Sloan, Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S Pace, Jasmine Kaur, Jeffrey P Murry, Mini Balakrishnan, Paul A Moore, Syd Johnson, Jeffrey L Nordstrom, Tomas Cihlar, Scott Koenig
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005233 (2015)
HIV reservoirs and production of viral antigens are not eliminated in chronically infected participants treated with combination antiretroviral therapy (cART). Novel therapeutic strategies aiming at viral reservoir elimination are needed to address c
Externí odkaz:
https://doaj.org/article/b748f788913f41528226c5ca0c716a56
Autor:
Datsen George Wei, Vicki Chiang, Elizabeth Fyne, Mini Balakrishnan, Tiffany Barnes, Michael Graupe, Joseph Hesselgesser, Alivelu Irrinki, Jeffrey P Murry, George Stepan, Kirsten M Stray, Angela Tsai, Helen Yu, Jonathan Spindler, Mary Kearney, Celsa A Spina, Deborah McMahon, Jacob Lalezari, Derek Sloan, John Mellors, Romas Geleziunas, Tomas Cihlar
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004071 (2014)
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to d
Externí odkaz:
https://doaj.org/article/ac65303f63b846a6ab208ba464922569
Autor:
Bhawna Sharma, Elena Bekerman, Hoa Truong, Johnny Lee, Maria Gamez-Guerrero, Archana Boopathy, Rohit Mital, Katell Bidet Huang, Sarah Ahmadi-Erber, Raphaela Wimmer, Sophie Schulha, Henning Lauterbach, Klaus Orlinger, Silpa Suthram, Mark G. Lewis, Wade Blair, Tariro Makadzange, Romas Geleziunas, Jeffrey P. Murry, Sarah Schmidt
Publikováno v:
Vaccines, Vol 12, Iss 7, p 735 (2024)
Arenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV) aren
Externí odkaz:
https://doaj.org/article/12cd484f588c476caa2e1468f51b5006
Autor:
John D. Ventura, Joseph P. Nkolola, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Noe B. Mercado, David L. Hope, Victoria M. Giffin, Katherine McMahan, Romas Geleziunas, Jeffrey P. Murry, Yunling Yang, Mark G. Lewis, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure research. In this study, we investigated the therapeutic efficacy of a vaccine consisti
Externí odkaz:
https://doaj.org/article/e42cb38a5f4c44cdb752a66e3a3f759b
Autor:
Victoria E. K. Walker-Sperling, Noe B. Mercado, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola, Mark Lewis, Jeffrey P. Murry, Yunling Yang, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Dan H. Barouch
Publikováno v:
Nature communications. 13(1)
The latent viral reservoir is the critical barrier for developing an HIV-1 cure. Previous studies have shown that therapeutic vaccination or broadly neutralizing antibody (bNAb) administration, together with a Toll-like receptor 7 (TLR7) agonist, enh
Autor:
Sladjana Prisic, Robert N. Husson, Jeffrey P. Murry, Shichun Lun, Eric J. Rubin, Mushtaq Mir, Haidan Guo, Choong-Min Kang
Publikováno v:
Infection and Immunity. 87
To persist and cause disease in the host, Mycobacterium tuberculosis must adapt to its environment during infection. Adaptations include changes in nutrient utilization and alterations in growth rate. M. tuberculosis Rv1422 is a conserved gene of unk
Autor:
Rebecca Hoh, Jeffrey P. Murry, Alivelu Irrinki, Tomas Cihlar, Garry P. Nolan, Li Li, Stefan Pflanz, Christopher W. Pohlmeyer, Aaron Arvey, Veronica D. Gonzalez, Steven G. Deeks, Gundula Min-Oo, Andrew Mulato, George Kukolj, Ricardo Ramirez
Publikováno v:
Journal of virology, vol 93, iss 7
HIV infection is controlled immunologically in a small subset of infected individuals without antiretroviral therapy (ART), though the mechanism of control is unclear. CD8(+) T cells are a critical component of HIV control in many immunological contr
Autor:
Francis Hong, Derek D. Sloan, Jeffrey P. Murry, Jasmine Kaur, Mattie Follen, Alivelu Irrinki, Sandra S. Win, John W. Mellors, Romas Geleziunas, Angela Tsai, Tomas Cihlar, Anthony R. Cillo
Publikováno v:
AIDS (London, England). 32(6)
OBJECTIVE To define the relationships between molecular measures of viral persistence in blood (i.e., plasma viremia, cellular HIV-1 DNA, and mRNA) and expressed or inducible virus from resting CD4 T cells of individuals on suppressive antiretroviral