Zobrazeno 1 - 10
of 451
pro vyhledávání: '"Jeffrey P, MacKeigan"'
Autor:
Krinio Giannikou, Katie R. Martin, Ahmad G. Abdel-Azim, Kaila J. Pamir, Thomas R. Hougard, Shefali Bagwe, Yan Tang, Jeffrey P. MacKeigan, David J. Kwiatkowski, Elizabeth P. Henske, Hilaire C. Lam
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Tuberous Sclerosis Complex (TSC) is caused by loss of function variants in either TSC1 or TSC2 and is characterized by broad phenotypic heterogeneity. Currently, there is limited knowledge regarding the role of the mitochondrial genome (mtDNA) in TSC
Externí odkaz:
https://doaj.org/article/7a16e35977df4b36bf8e5045581ebf3c
Publikováno v:
Cancers, Vol 15, Iss 4, p 1158 (2023)
Cancer cells utilize variable metabolic programs in order to maintain homeostasis in response to environmental challenges. To interrogate cancer cell reliance on glycolytic programs under different nutrient availabilities, we analyzed a gene panel co
Externí odkaz:
https://doaj.org/article/4b82f0920914458d93b13539d378575c
Autor:
Robert M. Vaughan, Jennifer J. Kordich, Chun-Yuan Chan, Nanda K. Sasi, Stephanie L. Celano, Kellie A. Sisson, Megan Van Baren, Matthew G. Kortus, Dean J. Aguiar, Katie R. Martin, Jeffrey P. MacKeigan
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The tuberous sclerosis complex (TSC) is a rare genetic syndrome and multisystem disease resulting in tumor formation in major organs. A molecular hallmark of TSC is a dysregulation of the mammalian target of rapamycin (mTOR) through loss-of-function
Externí odkaz:
https://doaj.org/article/6b788d8dffba41d183d8e4244c25e1f9
Autor:
Stephanie L. Celano, Lisette P. Yco, Matthew G. Kortus, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Edward Spooner, Ronan C. O'Hagan, Peter Fuller, Katie R. Martin, Stuart D. Shumway, Jeffrey P. MacKeigan
Publikováno v:
iScience, Vol 15, Iss , Pp 109-118 (2019)
Summary: In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor
Externí odkaz:
https://doaj.org/article/1963b7c4000c4a54a648f6f246f51215
Autor:
Katie R. Martin, Stephanie L. Celano, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Ronan C. O'Hagan, Stuart D. Shumway, Peter Fuller, Jeffrey P. MacKeigan
Publikováno v:
iScience, Vol 8, Iss , Pp 74-84 (2018)
Summary: In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer tr
Externí odkaz:
https://doaj.org/article/da31c51b36c548718b2b7aeb41c96998
Autor:
Nanda Kumar Sasi, Flavie Coquel, Yea-Lih Lin, Jeffrey P MacKeigan, Philippe Pasero, Michael Weinreich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 10, Pp 985-995 (2018)
Summary: CDC7-DBF4 kinase (DDK) initiates DNA replication in eukaryotes by activating the replicative MCM helicase. DDK has diverse and apparently conflicting roles in the replication checkpoint response in various organisms, but the underlying mecha
Externí odkaz:
https://doaj.org/article/bb1c67a26bea41f6b90ce1548bb39b94
Autor:
Katie R. Martin, Wanding Zhou, Megan J. Bowman, Juliann Shih, Kit Sing Au, Kristin E. Dittenhafer-Reed, Kellie A. Sisson, Julie Koeman, Daniel J. Weisenberger, Sandra L. Cottingham, Steven T. DeRoos, Orrin Devinsky, Mary E. Winn, Andrew D. Cherniack, Hui Shen, Hope Northrup, Darcy A. Krueger, Jeffrey P. MacKeigan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem tumour growth. Here the authors analyse 111 TSC-associated tissues for TSC1/TSC2 status, DNA mutations, copy number aberrations, differential gene expression and DNA methy
Externí odkaz:
https://doaj.org/article/cce878691c884b4cbf1df21c1d12c2c9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 5, Pp 439-450 (2017)
DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4. Both subunits are highly expressed in many diverse tumor cell lines and
Externí odkaz:
https://doaj.org/article/7cb955dcc1b5490eb08c9672b832c9d0
Autor:
Bin T. Teh, Kyle A. Furge, Jeffrey P. MacKeigan, Kristin Feenstra, Brendan D. Looyenga, David Petillo, Josh Smith, Zhongfa Zhang, Dan Huang, Yan Ding
XLS file - 40KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f65a8da9879274d472a72986029042
https://doi.org/10.1158/0008-5472.22387706.v1
https://doi.org/10.1158/0008-5472.22387706.v1
Autor:
Bin T. Teh, Kyle A. Furge, Jeffrey P. MacKeigan, Kristin Feenstra, Brendan D. Looyenga, David Petillo, Josh Smith, Zhongfa Zhang, Dan Huang, Yan Ding
XLS file - 168K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1484033f3ef6b4bcbd07b9c8dc7fcdd7
https://doi.org/10.1158/0008-5472.22387709.v1
https://doi.org/10.1158/0008-5472.22387709.v1