Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jeffrey P, Krise"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49366 (2012)
Drug distribution in cells is a fundamentally important, yet often overlooked, variable in drug efficacy. Many weakly basic anticancer agents accumulate extensively in the acidic lysosomes of normal cells through ion trapping. Lysosomal trapping redu
Externí odkaz:
https://doaj.org/article/ff8f6756132541a2b8c9f313906f7f9c
Publikováno v:
Journal of Pharmaceutical Sciences. 102:4173-4180
Many currently approved drugs possess weakly basic properties that make them substrates for extensive sequestration in acidic intracellular compartments such as lysosomes through an ion trapping-type mechanism. Lysosomotropic drugs often have unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd1aed74bc96b52497539b145239d3d
https://doi.org/10.1002/jps.23706
https://doi.org/10.1002/jps.23706
Autor:
Jeffrey P. Krise, Nadia Hamid
Publikováno v:
Lysosomes: Biology, Diseases, and Therapeutics: Biology, Diseases, and Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27ce61353557cd695855a4f0f95f894
https://doi.org/10.1002/9781118978320.ch18
https://doi.org/10.1002/9781118978320.ch18
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:120-128
The distribution behavior of a drug within a cell is an important, yet often overlooked, variable in both activity and differential selectivity. In normal cells, drugs with weakly basic properties are known to be extensively compartmentalized in acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61b7274a41211a68a1ca19caf9a9609
https://doi.org/10.1124/jpet.109.160226
https://doi.org/10.1124/jpet.109.160226
Publikováno v:
Bioanalysis. 1:1445-1459
The human body is continuously exposed to small organic molecules containing one or more basic nitrogen atoms. Many of these are endogenous (i.e., neurotransmitters, polyamines and biogenic amines), while others are exogenously supplied in the form o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f045f4409bdb6b08fea76bc7e3a105c7
https://doi.org/10.4155/bio.09.128
https://doi.org/10.4155/bio.09.128
Publikováno v:
Analytical Biochemistry. 386:91-97
Traditionally, lysosomes have been considered to be a terminal endocytic compartment. Recent studies suggest that lysosomes are quite dynamic, being able to fuse with other late endocytic compartments as well as with the plasma membrane. Here we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac6b55b3b6cc9432628494d4c0ec691
https://doi.org/10.1016/j.ab.2008.11.036
https://doi.org/10.1016/j.ab.2008.11.036
Publikováno v:
Journal of Biological Chemistry. 283:24584-24593
Mutations in the late endosomal/lysosomal membrane protein Niemann-Pick C1 (NPC1) are known to cause a generalized block in retrograde vesicle-mediated transport, resulting in the hyper-accumulation of multiple lysosomal cargos. An important, yet oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625a13b3b2d22f187a8263932a4767af
https://doi.org/10.1074/jbc.m803715200
https://doi.org/10.1074/jbc.m803715200
Autor:
Diane M. Ignar, Jason D. Speake, Yuping Gong, Zhiyang Zhao, Beth Beaudet, Jeffrey P. Krise, Melanie N. Tallman, Donavon J. McConn
Publikováno v:
Pharmaceutical Research. 24:1138-1144
A series of melanocortin-4 receptor (MC4R) agonists, developed for use as anti-obesity agents, were found to have unusual pharmacokinetic behavior arising from excessive retention in the liver, with nearly undetectable levels in plasma following oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa6df8b2f425ed6d0ec5f10390efbe0
https://doi.org/10.1007/s11095-007-9239-y
https://doi.org/10.1007/s11095-007-9239-y
Publikováno v:
ACS Chemical Biology. 1:309-315
The degree to which anticancer agents selectively target cancer cells is a key determinant in successful therapeutic outcomes. Inhibitors of the Hsp90 molecular chaperone represent an important new class of anticancer agents. We propose here a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e222e6afa2f57e08426d62f49ab07193
https://doi.org/10.1021/cb6001202
https://doi.org/10.1021/cb6001202
Publikováno v:
Biochemistry. 44:15743-15749
A number of multidrug-resistant (MDR) cancer cells have been shown to have acquired an increased capacity to sequester weakly basic anticancer drugs in their lysosomes relative to drug-sensitive counterparts. In this report we have comparatively eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa2c0a94b215f454a972662cbeddd5b
https://doi.org/10.1021/bi051759w
https://doi.org/10.1021/bi051759w