Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Jeffrey P, Chang"'
Autor:
Reid T. Powell, Amanda L. Rinkenbaugh, Lei Guo, Shirong Cai, Jiansu Shao, Xinhui Zhou, Xiaomei Zhang, Sabrina Jeter-Jones, Chunxiao Fu, Yuan Qi, Faiza Baameur Hancock, Jason B. White, Clifford Stephan, Peter J. Davies, Stacy Moulder, W. Fraser Symmans, Jeffrey T. Chang, Helen Piwnica-Worms
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Triple negative breast cancer (TNBC) accounts for 15–20% of breast cancer cases in the United States. Systemic neoadjuvant chemotherapy (NACT), with or without immunotherapy, is the current standard of care for patients with early-stage TN
Externí odkaz:
https://doaj.org/article/388c05310d9142b793c6b22617755d55
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Tumors are comprised of subpopulations of cancer cells that harbor distinct genetic profiles and phenotypes that evolve over time and during treatment. By reconstructing the course of cancer evolution, we can understand the acquisition of th
Externí odkaz:
https://doaj.org/article/32809e00495645f1b0e0865e48743292
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Publications comparing variant caller algorithms present discordant results with contradictory rankings. Caller performances are inconsistent and wide ranging, and dependent upon input data, application, parameter settings, and evaluation me
Externí odkaz:
https://doaj.org/article/785a225b493f45888aa181d81784c2aa
Autor:
Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, Dina Montufar-Solis, Wei Chen, Maurice Wong, Yong Zhou, Carlito B. Lebrilla, John F. Hancock
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
KRAS is a small GTPase that regulates cell proliferation. Here, the authors show that a subset of cell surface glycosphingolipids regulate KRAS plasma membrane localization by modulating inner leaflet lipid composition, uncovering a requirement for K
Externí odkaz:
https://doaj.org/article/7c042b78ee0049b58df0d81f70b376de
Autor:
Gloria V. Echeverria, Shirong Cai, Yizheng Tu, Jiansu Shao, Emily Powell, Abena B. Redwood, Yan Jiang, Aaron McCoy, Amanda L. Rinkenbaugh, Rosanna Lau, Alexander J. Trevarton, Chunxiao Fu, Rebekah Gould, Elizabeth E. Ravenberg, Lei Huo, Rosalind Candelaria, Lumarie Santiago, Beatriz E. Adrada, Deanna L. Lane, Gaiane M. Rauch, Wei T. Yang, Jason B. White, Jeffrey T. Chang, Stacy L. Moulder, W. Fraser Symmans, Susan G. Hilsenbeck, Helen Piwnica-Worms
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. We established orthotopic PDX models of triple negative breast cancer (T
Externí odkaz:
https://doaj.org/article/1aeaec90b47b427c8b0d10b0dad9ddf6
Autor:
Hui Chen, Qingqing Ding, Laila Khazai, Li Zhao, Senthil Damodaran, Jennifer K. Litton, Gaiane M. Rauch, Clinton Yam, Jeffrey T. Chang, Sahil Seth, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz Adrada, Kiran Virani, Jason B. White, Elizabeth Ravenberg, Xingzhi Song, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Mark J. Routbort, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Debu Tripathy, Wei-Lien Wang, Stacy Moulder, Lei Huo
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Recent advances have been made in targeting the phosphoinositide 3-kinase pathway in breast cancer. Phosphatase and tensin homolog (PTEN) is a key component of that pathway. Objective: To understand the changes in PTEN expression over the
Externí odkaz:
https://doaj.org/article/d6308ee798424003bf82ce6d0277871d
Autor:
Xuan Liu, Zhongqi Ge, Fei Yang, Alejandro Contreras, Sanghoon Lee, Jason B. White, Yiling Lu, Marilyne Labrie, Banu K. Arun, Stacy L. Moulder, Gordon B. Mills, Helen Piwnica-Worms, Jennifer K. Litton, Jeffrey T. Chang
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Germline mutations in BRCA1 or BRCA2 exist in ~2–7% of breast cancer patients, which has led to the approval of PARP inhibitors in the advanced setting. We have previously reported a phase II neoadjuvant trial of single agent talazoparib f
Externí odkaz:
https://doaj.org/article/c1596f6b174a47a78043a40e8d62cdcd
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background Using endoscopy as the reference, this study evaluated the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in measuring distance from the incisors to the PET detectable esophageal c
Externí odkaz:
https://doaj.org/article/bc36089529d24c94b8b7cdef14c56d7a
Autor:
Zheng Wang, Mohit Hulsurkar, Lijuan Zhuo, Jinbang Xu, Han Yang, Samira Naderinezhad, Lin Wang, Guoliang Zhang, Nanping Ai, Linna Li, Jeffrey T. Chang, Songlin Zhang, Ladan Fazli, Chad J. Creighton, Fang Bai, Michael M. Ittmann, Martin E. Gleave, Wenliang Li
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 11, Pp 1147-1165 (2021)
Epithelial-mesenchymal transition (EMT) contributes to tumor invasion, metastasis and drug resistance. AKT activation is key in a number of cellular processes. While many positive regulators for either EMT or AKT activation have been reported, few ne
Externí odkaz:
https://doaj.org/article/8c48a73040db41e99238a7ba9fbf044c
Autor:
Vrutant V. Shah, Aundrietta D. Duncan, Shiming Jiang, Sabrina A. Stratton, Kendra L. Allton, Clinton Yam, Abhinav Jain, Patrick M. Krause, Yue Lu, Shirong Cai, Yizheng Tu, Xinhui Zhou, Xiaomei Zhang, Yan Jiang, Christopher L. Carroll, Zhijun Kang, Bin Liu, Jianjun Shen, Mihai Gagea, Sebastian M. Manu, Lei Huo, Michael Gilcrease, Reid T. Powell, Lei Guo, Clifford Stephan, Peter J. Davies, Jan Parker-Thornburg, Guillermina Lozano, Richard R. Behringer, Helen Piwnica-Worms, Jeffrey T. Chang, Stacy L. Moulder, Michelle Craig Barton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Human metaplastic breast cancers (MpBC) are a rare, aggressive subclass of triple-negative breast cancers. Here, the authors show over-expression of histone reader TRIM24 is sufficient to generate tumors with a molecular signature of metabolic dysfun
Externí odkaz:
https://doaj.org/article/d198e1ab2b18460f8fd9661445a6e392