Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey O. Blaisdell"'
Autor:
Jeffrey O. Blaisdell, Susan S. Wallace
Publikováno v:
Nucleic Acids Research
Current methods to measure the fraction of active glycosylase molecules in a given enzyme preparation are slow and cumbersome. Here we report a novel assay for rapidly determining the active fraction based on molecular accessibility of a fluorescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5be67c83121b25f791f5905630c8aa
https://doi.org/10.1093/nar/gkm021
https://doi.org/10.1093/nar/gkm021
Publikováno v:
Journal of Biological Chemistry. 280:34378-34384
Escherichia coli endonuclease III (EcoNth) plays an important cellular role by removing premutagenic pyrimidine damages produced by reactive oxygen species. EcoNth is a bifunctional enzyme that has DNA glycosylase and apurinic/apyrimidinic lyase acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e204bc525239a553ecc962075329b8
https://doi.org/10.1074/jbc.m504916200
https://doi.org/10.1074/jbc.m504916200
Publikováno v:
Radiation Protection Dosimetry. 97:25-31
Energy from low LET ionising radiation, such as X rays and gamma rays, is deposited in the water surrounding the DNA molecule such that between 2 to 5 radical pairs are generated within a radius of I to 4 nm. As a result, multiple single lesions, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef22d6bd5dc8a93fb9082494ffaf2e6
https://doi.org/10.1093/oxfordjournals.rpd.a006634
https://doi.org/10.1093/oxfordjournals.rpd.a006634
Autor:
Douglas I. Johnson, Cynthia R. Davis, Cheryl Collins, Jeffrey O. Blaisdell, Tamara J. Richman, Steven B. Deliduka
Publikováno v:
Journal of Biological Chemistry. 273:849-858
The Saccharomyces cerevisiae Cdc42p GTPase is localized to the plasma membrane and involved in signal transduction mechanisms controlling cell polarity. The mechanisms of action of the dominant negative cdc42(D118A) mutant and the lethal, gain of fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f5adbf7af83d414a1093cf6548c047
https://doi.org/10.1074/jbc.273.2.849
https://doi.org/10.1074/jbc.273.2.849
Publikováno v:
Europe PubMed Central
Escherichia coli possesses two DNA glycosylase/apurinic lyase activities with overlapping substrate specificities, endonuclease III and endonuclease VIII, that recognize and remove oxidized pyrimidines from DNA. Endonuclease III is encoded by the nth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34687b24fa115b734d10f2b0a2e5d1b8
https://doi.org/10.1128/jb.179.11.3773-3782.1997
https://doi.org/10.1128/jb.179.11.3773-3782.1997
Publikováno v:
Methods in enzymology. 408
As new organisms are being sequenced on a daily basis, new DNA glycosylases that recognize DNA damage can be easily identified in an effort to understand both their phylogenetics and substrate specificities. As a practical matter, existing bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::289c006308e23a5abbb8ae447af8549e
https://pubmed.ncbi.nlm.nih.gov/16793360
https://pubmed.ncbi.nlm.nih.gov/16793360
As new organisms are being sequenced on a daily basis, new DNA glycosylases that recognize DNA damage can be easily identified in an effort to understand both their phylogenetics and substrate specificities. As a practical matter, existing bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98c2459858c1c29f11f02e594c28a60
https://doi.org/10.1016/s0076-6879(06)08002-5
https://doi.org/10.1016/s0076-6879(06)08002-5
Escherichia coli formamidopyrimidine DNA glycosylase (Fpg), MutY DNA glycosylase, endonuclease VIII, and endonuclease III are oxidative base excision repair DNA glycosylases that remove oxidized bases from DNA, or an incorrect base paired with an oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e938eae3d741dbc5faf990ffb8e2bc4
https://europepmc.org/articles/PMC110984/
https://europepmc.org/articles/PMC110984/
In the bacterium Escherichia coli , oxidized pyrimidines are removed by two DNA glycosylases, endonuclease III and endonuclease VIII (endo VIII), encoded by the nth and nei genes, respectively. Double mutants lacking both of these activities exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0965bb61e4f78a5fa55f23f9972e4b2f
https://europepmc.org/articles/PMC103775/
https://europepmc.org/articles/PMC103775/
Autor:
Dongyan Jiang, Andrei Purmal, Susan S. Wallace, Jeffrey O. Blaisdell, Lynn Harrison, Zafer Hatahet
Publikováno v:
Advances in DNA Damage and Repair ISBN: 9781461372073
DNA base lesions produced by free radicals are common products of normal oxidative metabolism. These lesions are removed by base excision repair processing, the first step of which is recognition of the base lesion by a DNA-glycosylase. In general, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd33df12f95f3ae4cbfe5575abe4d68
https://doi.org/10.1007/978-1-4615-4865-2_34
https://doi.org/10.1007/978-1-4615-4865-2_34