Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Jeffrey N. Weiser"'
Autor:
Anne-Stéphanie Rueff, Renske van Raaphorst, Surya D. Aggarwal, Javier Santos-Moreno, Géraldine Laloux, Yolanda Schaerli, Jeffrey N. Weiser, Jan-Willem Veening
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Phenotypic variation is the phenomenon in which clonal cells display different traits even under identical environmental conditions. This plasticity is thought to be important for processes including bacterial virulence, but direct evidence
Externí odkaz:
https://doaj.org/article/e8c7dfd4d89b4c2a9b32de5868db46ec
Autor:
Mila B. Ortigoza, Catherina L. Mobini, Hedy L. Rocha, Stacey Bartlett, Cynthia A. Loomis, Jeffrey N. Weiser
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The ongoing transmission of influenza A viruses (IAV) for the past century continues to be a burden to humans. IAV binds terminal sialic acids (SA) of sugar molecules present within the upper respiratory tract (URT) in order to successfully
Externí odkaz:
https://doaj.org/article/97e848cdca4a4952b74b5bba6c6a0594
Autor:
Tonia Zangari, M. Ammar Zafar, John A. Lees, Annie R. Abruzzo, Gavyn Chern Wei Bee, Jeffrey N. Weiser
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on capsular polysaccharide and its serotype diversity. More broadly-based approaches using common protein antigens have not resulted in a licensed vaccine. Herein, w
Externí odkaz:
https://doaj.org/article/181763b877054cdb834eea67101b2637
Autor:
Maria G. Noval, Maria E. Kaczmarek, Akiko Koide, Bruno A. Rodriguez-Rodriguez, Ping Louie, Takuya Tada, Takamitsu Hattori, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Andrew Bazley, Maren de Vries, Marie I. Samanovic, Jeffrey N. Weiser, Ioannis Aifantis, Joan Cangiarella, Mark J. Mulligan, Ludovic Desvignes, Meike Dittmann, Nathaniel R. Landau, Maria Aguero-Rosenfeld, Shohei Koide, Kenneth A. Stapleford
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutraliz
Externí odkaz:
https://doaj.org/article/431b486be8244906b88b8f8c1a505e1f
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Capsule-switch mutants were compared to analyze how serotype affects the success of Streptococcus pneumoniae (Spn) during colonization and transmission. Strains of multiple serotypes were tested in highly susceptible infant mice, both singly
Externí odkaz:
https://doaj.org/article/d1460143100e4effb63ed74dd203024d
Autor:
John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi
Externí odkaz:
https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3
Autor:
Daichi Murakami, Masamitsu Kono, Denisa Nanushaj, Fumie Kaneko, Tonia Zangari, Yasuteru Muragaki, Jeffrey N. Weiser, Muneki Hotomi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Streptococcus pneumoniae, one of the most common commensal pathogens among children, is spread by close contact in daycare centers or within a family. Host innate immune responses and bacterial virulence factors promote pneumococcal transmission. How
Externí odkaz:
https://doaj.org/article/c485e5c1fa2d4b0693fc519a2f0cc13e
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Respiratory tract infections are a leading cause of childhood mortality and, globally, Streptococcus pneumoniaeS. pneumoniae
Externí odkaz:
https://doaj.org/article/dbe7f03ca2454e6dbe6a797dc82e25fb
Autor:
M. Ammar Zafar, Alexandria J. Hammond, Shigeto Hamaguchi, Weisheng Wu, Masamitsu Kono, Lili Zhao, Jeffrey N. Weiser
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Host-to-host transmission is a necessary but poorly understood aspect of microbial pathogenesis. Herein, we screened a genomic library of mutants of the leading respiratory pathogen Streptococcus pneumoniae generated by mariner transposon mu
Externí odkaz:
https://doaj.org/article/b6c89ed1bffe4b75a6bd6fe0635854ad
Autor:
Mila Brum Ortigoza, Simone B. Blaser, M. Ammar Zafar, Alexandria J. Hammond, Jeffrey N. Weiser
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT The pandemic potential of influenza A viruses (IAV) depends on the infectivity of the host, transmissibility of the virus, and susceptibility of the recipient. While virus traits supporting IAV transmission have been studied in detail using
Externí odkaz:
https://doaj.org/article/6f3a6c5a33cb48f6a42d34080b1185c3