Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jeffrey N. Masters"'
Publikováno v:
Xenobiotica. 42:863-871
We describe the usability of human pooled hepatocytes for non-CYP metabolism evaluation and an in vivo-in vitro correlation analysis for aldehyde oxidase (AO) substrate compounds using pooled hepatocytes. By comparing intrinsic clearance values of 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c81228319f5a334668d80dbb833a6f
https://doi.org/10.3109/00498254.2012.670736
https://doi.org/10.3109/00498254.2012.670736
Autor:
Earl J. Gubbins, Loan N. Miller, Marc A. Terranova, Robert B. Moreland, Jeffrey N. Masters, Odile F. El-Kouhen, Diana L. Donnelly-Roberts, Marie E. Uchic, Jorge D. Brioni, Marian T. Namovic, Rosalind J. Helfrich, Renjie Chang, Masaki Nakane
Publikováno v:
Biochemical Pharmacology. 68:761-772
The goal of this study was to develop a new approach to study the pharmacology of the dopamine D 4 receptor that could be used in comparative studies with dopamine D 2 and D 3 receptors. Stable HEK-293 cell lines co-expressing recombinant human D 2L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818abcb51ef171c8a2755e5167e2b4e7
https://doi.org/10.1016/j.bcp.2004.05.019
https://doi.org/10.1016/j.bcp.2004.05.019
Autor:
Robert B. Moreland, Usha Warrior, Diana L. Donnelly-Roberts, Jennifer McGowen, Jeffrey N. Masters, Jorge D. Brioni, James L. Kofron, Rosalind J. Helfrich, David J. Burns, Earl J. Gubbins, Sujatha M. Gopalakrishnan
Publikováno v:
Analytical Biochemistry. 321:192-201
The identification of agonist and antagonist leads for G-protein-coupled receptors (GPCRs) is of critical importance to the pharmaceutical and biotechnology industries. We report on the utilization of a novel, high-density, well-less screening platfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e67a365aacd8a2ecec23115435f0203
https://doi.org/10.1016/s0003-2697(03)00425-1
https://doi.org/10.1016/s0003-2697(03)00425-1
Publikováno v:
Pharmacology Research & Perspectives
Metabolism and sinusoidal/canalicular efflux of mycophenolic acid (MPA) was investigated using sandwich-cultured hepatocytes (SCHs). After applying MPA to SCHs from humans, wild-type rats, and multidrug resistance-associated protein (Mrp) 2-deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dacf933d9da256c2b6e6ebd4995cb8
https://doi.org/10.1002/prp2.35
https://doi.org/10.1002/prp2.35
Publikováno v:
Drug metabolism and pharmacokinetics. 29(2)
Rat sandwich-cultured hepatocytes (SCH) were used to correlate the in vitro hepatic disposition of mycophenolic acid (MPA) with published in vivo data, as well as mechanistic studies on drug-drug interaction. The major metabolite of MPA in SCH was 7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3932d243ddd7f8945dfb1ea61437c472
https://pubmed.ncbi.nlm.nih.gov/24025987
https://pubmed.ncbi.nlm.nih.gov/24025987
Publikováno v:
Journal of Molecular Neuroscience. 7:203-215
CR16 is a glucocorticoid-regulated gene expressed in subpopulations of neurons in the brain, including the hippocampus. The CR16 open reading frame encodes a 45 kDa protein containing 32% proline. To begin characterizing the CR16 protein, a rabbit po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e97d01cf5d5b8600b26a992ea8a2473
https://doi.org/10.1007/bf02736841
https://doi.org/10.1007/bf02736841
Publikováno v:
Neuroendocrinology. 63:28-38
A novel cDNA clone, CR16, was isolated from a rat hippocampal cDNA library and characterized for responses to corticosteroids and regional expression. The 4-kb RNA was increased 3-fold by treatment of adrenalectomized (ADX) rats with corticosterone (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70492d608fce16b889c91d7cbb8c823e
https://doi.org/10.1159/000126932
https://doi.org/10.1159/000126932
Publikováno v:
Neuroendocrinology. 60:23-35
Twenty-five years ago, glycerol phosphate dehydrogenase (GPDH, EC 1.1.1.8) was described as a hormonally dependent enzyme in the brain, and since then has been characterized for its developmental regulation and as a marker for oligodendrocytes. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6abf44f0c7b87378ba72e1fd8e836e
https://doi.org/10.1159/000126716
https://doi.org/10.1159/000126716
Publikováno v:
Drug metabolism and pharmacokinetics. 27(2)
Human hepatocytes are a physiologically relevant tool useful in evaluating liver-related pharmacokinetics, including non-cytochrome P-450 (CYP) metabolism, due to their broad spectrum of metabolic enzyme activity. To verify the usefulness of human he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6268fcda14343fa34f0318447be17cb5
https://pubmed.ncbi.nlm.nih.gov/22027494
https://pubmed.ncbi.nlm.nih.gov/22027494
Publikováno v:
Developmental Brain Research. 73:253-259
Mechanisms controlling the synthesis of corticotropin releasing hormone (CRH) in neonatal rats, and the ontogeny of glucocorticoid (GC) feedback control of hypothalamic CRH remain unknown. Specific issues are whether stress induces up-regulation of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a68e75eb3b1e0fe9a232928054a8e1
https://doi.org/10.1016/0165-3806(93)90145-z
https://doi.org/10.1016/0165-3806(93)90145-z