Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jeffrey N. Higaki"'
Publikováno v:
Clinical Science. 131:395-409
Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is an underdiagnosed and important type of cardiomyopathy and/or polyneuropathy that requires increased awareness within the medical community. Raising awareness among clinicians about this type of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6165291a1dcc6db0b0b908a2bedf0cc0
https://doi.org/10.1042/cs20160413
https://doi.org/10.1042/cs20160413
Autor:
Nijjar Tarlochan S, Stephen J. Tam, Bradley Hammerson, Avi Chakrabartty, Jose R. Tapia, Robin Barbour, Ronald Torres, Gene G. Kinney, Ken Flanagan, Wagner Zago, Salmans Joshua Reginald, Jeffrey N. Higaki, Kevin C. Hadley, Natalie J. Galant
Publikováno v:
Amyloid
Introduction: Transthyretin amyloidosis (ATTR amyloidosis) is caused by the misfolding and deposition of the transthyretin (TTR) protein and results in progressive multi-organ dysfunction. TTR epitopes exposed by dissociation and misfolding are targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53abd6c8fd0d213c6e3ad3032fcb1ab3
https://doi.org/10.3109/13506129.2016.1148025
https://doi.org/10.3109/13506129.2016.1148025
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d024a023711207e4558bd707a9af7e
https://doi.org/10.1016/j.jalz.2016.06.2117
https://doi.org/10.1016/j.jalz.2016.06.2117
Autor:
Natalie J, Galant, Antoinette, Bugyei-Twum, Rishi, Rakhit, Patrick, Walsh, Simon, Sharpe, Pharhad Eli, Arslan, Per, Westermark, Jeffrey N, Higaki, Ronald, Torres, José, Tapia, Avijit, Chakrabartty
Publikováno v:
Scientific Reports
Wild-type and mutant transthyretin (TTR) can misfold and deposit in the heart, peripheral nerves, and other sites causing amyloid disease. Pharmacological chaperones, Tafamidis® and diflunisal, inhibit TTR misfolding by stabilizing native tetrameric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17449eb2f47457f9b66474ae258ef6a
https://doi.org/10.1038/srep27679
https://doi.org/10.1038/srep27679
Autor:
Simon Sharpe, Per Westermark, Antoinette Bugyei-Twum, Natalie J. Galant, Rishi Rakhit, Jose R. Tapia, Jeffrey N. Higaki, Ronald Torres, Avijit Chakrabartty, Patrick Walsh, Pharhad Eli Arslan
Publikováno v:
Scientific Reports
Wild-type and mutant transthyretin (TTR) can misfold and deposit in the heart, peripheral nerves, and other sites causing amyloid disease. Pharmacological chaperones, Tafamidis® and diflunisal, inhibit TTR misfolding by stabilizing native tetrameric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f507b8005a8f5f6a718f3dc64f93a58c
https://doi.org/10.1038/srep25080
https://doi.org/10.1038/srep25080
Autor:
Maureen Laney, Zheng Chen, Hanmin Dong, Dan-Xiong Wang, Albert Liclican, John J. Perumattam, Sundeep Dugar, Babu J. Mavunkel, Jeffrey N. Higaki, Yong-jin Xu, Daniel E. Levy, Qing Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2390-2394
A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to >20 μM and were dependant upon both the nature of the aryl group a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d27f70919fae8dd7c1a4db09ac409a
https://doi.org/10.1016/j.bmcl.2008.02.059
https://doi.org/10.1016/j.bmcl.2008.02.059
Autor:
Indrani Chakraborty, Qing Lu, Sundeep Dugar, Dan-Xiong Wang, Hui Wang, Albert Liclican, Ulrike Delling, Jeffrey N. Higaki, Steve Sideris, Zheng Chen, Maureen Laney, Linda S. Higgins, Wang Jing, Don Lim, Babu J. Mavunkel, Daniel E. Levy, Ying Feng, Bindu Goyal, Yong-jin Xu, Rosanne Catalano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2404-2408
Non-ATP competitive pyrimidine-based inhibitors of CaMKIIdelta were identified. Computational studies were enlisted to predict the probable mode of binding. The results of the computational studies led to the design of ATP competitive inhibitors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1804c1b50bdd920bb38053fe4b427f8
https://doi.org/10.1016/j.bmcl.2008.02.056
https://doi.org/10.1016/j.bmcl.2008.02.056
Autor:
Steven Do, Zheng Chen, Hanmin Dong, Maureen Laney, Llorente V. R. Bonaga, Weiling Liang, Albert Liclican, Qing Lu, Dan-Xiong Wang, Daniel E. Levy, John J. Perumattam, Jeffrey N. Higaki, Steve Sideris, Sundeep Dugar, Yong-jin Xu, Babu J. Mavunkel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2399-2403
A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 10 nM to >20 μM and were dependant upon both the nature of the aryl group a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04c112ed5fb356608ea6cec8241062e
https://doi.org/10.1016/j.bmcl.2008.02.057
https://doi.org/10.1016/j.bmcl.2008.02.057
Publikováno v:
Journal of Neurochemistry. 68:333-336
Several reports have suggested that the frequency of Alzheimer's disease (AD) neuropathology is significantly reduced in elderly individuals with schizophrenia (SZ), and it has been proposed that medications used for treatment of SZ may be responsibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac87d5c0ab655df7a4d0ed918b3c329
https://doi.org/10.1046/j.1471-4159.1997.68010333.x
https://doi.org/10.1046/j.1471-4159.1997.68010333.x
Autor:
Babu J. Mavunkel, Barbara Cordell, Jan Marian Scardina, Gregory R. Luedtke, Carmen M. Bryant, Jeffrey N. Higaki, Lisa R. Cowart, Sarvajit Chakravarty, Paul Harden
Publikováno v:
Journal of Medicinal Chemistry. 42:3889-3898
In an effort to rapidly identify potent inhibitors of Abeta production and to probe the amino acid sequence specificity of the protease(s) responsible for the production of this peptide, a large number of dipeptide aldehydes were combinatorially synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c164f37521fa3e92a41c229f7dda06
https://doi.org/10.1021/jm990009f
https://doi.org/10.1021/jm990009f