Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Jeffrey N Savas"'
Autor:
Ewa K Bomba-Warczak, Karen M Velez, Luhan T Zhou, Christelle Guillermier, Seby Edassery, Matthew L Steinhauser, Jeffrey N Savas, Francesca E Duncan
Publikováno v:
eLife, Vol 13 (2024)
The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that pers
Externí odkaz:
https://doaj.org/article/6aa92de16b3c4bd9af87d1fb9f1b6b64
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 2, Pp 120-139 (2024)
Abstract Efficient protein turnover is essential for cellular homeostasis and organ function. Loss of proteostasis is a hallmark of aging culminating in severe dysfunction of protein turnover. To investigate protein turnover dynamics as a function of
Externí odkaz:
https://doaj.org/article/0e68cce9b59d434580626510e56539f2
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy
Autor:
Sandra Donkervoort, Niklas Krause, Mykola Dergai, Pomi Yun, Judith Koliwer, Svetlana Gorokhova, Janelle Geist Hauserman, Beryl B Cummings, Ying Hu, Rosemarie Smith, Prech Uapinyoying, Vijay S Ganesh, Partha S Ghosh, Kristin G Monaghan, Seby L Edassery, Pia E Ferle, Sarah Silverstein, Katherine R Chao, Molly Snyder, Sara Ellingwood, Diana Bharucha‐Goebel, Susan T Iannaccone, Matteo Dal Peraro, A Reghan Foley, Jeffrey N Savas, Véronique Bolduc, Dirk Fasshauer, Carsten G Bönnemann, Michael Schwake
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-17 (2021)
Abstract BET1 is required, together with its SNARE complex partners GOSR2, SEC22b, and Syntaxin‐5 for fusion of endoplasmic reticulum‐derived vesicles with the ER‐Golgi intermediate compartment (ERGIC) and the cis‐Golgi. Here, we report three
Externí odkaz:
https://doaj.org/article/36e02f0c64b8417881fabf19320857cf
Publikováno v:
eLife, Vol 8 (2019)
The lenticular fiber cells are comprised of extremely long-lived proteins while still maintaining an active biochemical state. Dysregulation of these activities has been implicated in diseases such as age-related cataracts. However, the lenticular pr
Externí odkaz:
https://doaj.org/article/3ca3af7863aa408a8b3a22e686acd542
Autor:
Jean J Kim, Jeffrey N Savas, Meghan T Miller, Xindao Hu, Cassiano Carromeu, Mathieu Lavallée-Adam, Beatriz C G Freitas, Alysson R Muotri, John R Yates, Anirvan Ghosh
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212553 (2019)
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality. Induced pluripotent stem cell (iPSC) li
Externí odkaz:
https://doaj.org/article/87e01bbb9e4e45acaf98802445390387
Autor:
Ryo Yonashiro, Erich B Tahara, Mario H Bengtson, Maria Khokhrina, Holger Lorenz, Kai-Chun Chen, Yu Kigoshi-Tansho, Jeffrey N Savas, John R Yates III, Steve A Kay, Elizabeth A Craig, Axel Mogk, Bernd Bukau, Claudio AP Joazeiro
Publikováno v:
eLife, Vol 5 (2016)
Ribosome stalling during translation can potentially be harmful, and is surveyed by a conserved quality control pathway that targets the associated mRNA and nascent polypeptide chain (NC). In this pathway, the ribosome-associated quality control (RQC
Externí odkaz:
https://doaj.org/article/5ceb291f38b646cd975c66eb50299b36
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63879 (2013)
Unconventional prefoldin RPB5 Interactor (URI) was identified as a transcriptional repressor that binds RNA polymerase II (pol II) through interaction with the RPB5/POLR2E subunit. Despite the fact that many other proteins involved in transcription r
Externí odkaz:
https://doaj.org/article/bc6be783a4c740da9de43538f38b5f68
Autor:
Birsu Bac, Cheima Hicheri, Craig Weiss, Amelia Buell, Natalia Vilcek, Claudia Spaeni, Changiz Geula, Jeffrey N. Savas, John F. Disterhoft
Publikováno v:
Neurobiology of Aging. 123:98-110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46be5c225279db6a024b36cb31d57114
https://doi.org/10.1016/j.neurobiolaging.2022.12.015
https://doi.org/10.1016/j.neurobiolaging.2022.12.015
Autor:
Varda Lev-Ram, Sakina P. Lemieux, Thomas J. Deerinck, Eric A. Bushong, Brandon H. Toyama, Alex Perez, Denise R. Pritchard, Sung Kyu R. Park, Daniel B. McClatchy, Jeffrey N. Savas, Susan S. Taylor, Mark H. Ellisman, John Yates, Roger Y. Tsien
Publikováno v:
bioRxiv
Perineuronal nets (PNN), a specialized form of ECM (?), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure. We hypothesis that PNNs serve as gatekeepers that guard and protect synaptic territory, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb912379eb1f87fb672a04f071ddfef
https://doi.org/10.1101/2023.04.09.536164
https://doi.org/10.1101/2023.04.09.536164
Combinatorial expression of postsynaptic proteins underlies synapse diversity within and between neuron types1-5. Thus, characterization of neuron-type-specific postsynaptic proteomes is key to obtaining a deeper understanding of discrete synaptic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63bc51b7ca190040129829baa805a33c
https://doi.org/10.1101/2023.03.16.532957
https://doi.org/10.1101/2023.03.16.532957