Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Jeffrey N, Strathern"'
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004910 (2015)
Mutations accumulate during all stages of growth, but only germ line mutations contribute to evolution. While meiosis contributes to evolution by reassortment of parental alleles, we show here that the process itself is inherently mutagenic. We have
Externí odkaz:
https://doaj.org/article/77638ec6eb984a90aacd3904567099ff
Autor:
Jordan D Irvin, Maria L Kireeva, Deanna R Gotte, Brenda K Shafer, Ingold Huang, Mikhail Kashlev, Jeffrey N Strathern
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004532 (2014)
We developed a highly sensitive assay to detect transcription errors in vivo. The assay is based on suppression of a missense mutation in the active site tyrosine in the Cre recombinase. Because Cre acts as tetramer, background from translation error
Externí odkaz:
https://doaj.org/article/3b7cc81baf9a406c9a61dffbcec2933d
Autor:
Donald L. Court, Alison J. Rattray, Ding J. Jin, Mikhail Bubunenko, Xintian Li, Maria L. Kireeva, Deanna Gotte, Mikhail Kashlev, Jorge A. Irizarry-Caro, Jeffrey N. Strathern, Carolyn Court
Publikováno v:
Genetics
We made a coupled genetic reporter that detects rare transcription misincorporation errors to measure RNA polymerase transcription fidelity in Escherichia coli. Using this reporter, we demonstrated in vivo that the transcript cleavage factor GreA, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f3f87a8c0ae1fc2aa7ece4095308b9
http://europepmc.org/articles/PMC5419468
http://europepmc.org/articles/PMC5419468
Autor:
J. Brooks Jackson, Philippa Musoke, Jeffrey N. Strathern, Susan H. Eshleman, Chanjuan Shi, Dana Jones, Francis Mmiro, Dwight V. Nissley, Laura Guay, James R. Eshleman, Tamara Flys, Cassidy W. Claasen
Publikováno v:
J Infect Dis
The HIV Network for Prevention Trials (HIVNET) 012 trial showed that NVP resistance (NVPR) emerged in some women and children after the administration of single-dose nevirapine (SD-NVP). We tested whether K103N-containing human immunodeficiency virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2c44b4e3a79c052c77389921061880
https://pubmed.ncbi.nlm.nih.gov/15942890
https://pubmed.ncbi.nlm.nih.gov/15942890
Autor:
Deanna Gotte, Maria L. Kireeva, Lucyna Lubkowska, Jeffrey N. Strathern, Jordan D. Irvin, Francisco Malagon, Brenda Shafer, Mikhail Kashlev, Ding Jun Jin
Publikováno v:
Journal of Biological Chemistry. 288:2689-2699
The fidelity of RNA synthesis depends on both accurate template-mediated nucleotide selection and proper maintenance of register between template and RNA. Loss of register, or transcriptional slippage, is particularly likely on homopolymeric runs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a3dde217f1102f686e3d4cc43196ba
https://doi.org/10.1074/jbc.m112.429506
https://doi.org/10.1074/jbc.m112.429506
Autor:
Alissa A. Hare, Timothy R. Welch, Jeffrey N. Strathern, Liang Xu, Dong Wang, Ji Hyun Shin, Peter B. Dervan, Wei Wang, Fei Yang, Benjamin C. Li, Jenny Chong, Deanna Gotte
RNA polymerase II (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, DNA lesions, and nucleosomes. Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with programmable sequence specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940e020de05acfdca9748b12e7a37fe9
https://resolver.caltech.edu/CaltechAUTHORS:20161020-165432331
https://resolver.caltech.edu/CaltechAUTHORS:20161020-165432331
Autor:
Patrick Cramer, Jeffrey N. Strathern, Alan C. M. Cheung, Mikhail Kashlev, Maria L. Kireeva, Celine Walmacq, Thomas Carell, Chengcheng Ye, Lucyna Lubkowska, Deanna Gotte
Publikováno v:
Molecular Cell
Summary UV-induced cyclobutane pyrimidine dimers (CPDs) in the template DNA strand stall transcription elongation by RNA polymerase II (Pol II). If the nucleotide excision repair machinery does not promptly remove the CPDs, stalled Pol II creates a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a94bdcb243e0129877a3707e39b6d01
Autor:
Jordan D. Irvin, Jeffrey N. Strathern, Maria L. Kireeva, Lucyna Lubkowska, Francisco Malagon, Mikhail Kashlev, Yuri A. Nedialkov, Celine Walmacq
Publikováno v:
Journal of Biological Chemistry. 284:19601-19612
Rpb9 is a small non-essential subunit of yeast RNA polymerase II located on the surface on the enzyme. Deletion of the RPB9 gene shows synthetic lethality with the low fidelity rpb1-E1103G mutation localized in the trigger loop, a mobile element of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e9189bfa47986b355cdaebec993f9d
https://doi.org/10.1074/jbc.m109.006908
https://doi.org/10.1074/jbc.m109.006908
Autor:
Gina H. Cremona, Mikhail Kashlev, Francisco Malagon, Zachary F. Burton, Yuri A. Purtov, Yuri A. Nedialkov, Maria L. Kireeva, Jeffrey N. Strathern, Lucyna Lubkowska
Publikováno v:
Mol Cell
To study fidelity of RNA polymerase II (Pol II), we analyzed properties of the 6-azauracil-sensitive and TFIIS-dependent E1103G mutant of rbp1 (rpo21), the gene encoding the catalytic subunit of Pol II in Saccharomyces cerevisiae. Using an in vivo re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ddac9d8f16acca0f2d00a5d9cdf047
https://doi.org/10.1016/j.molcel.2008.04.017
https://doi.org/10.1016/j.molcel.2008.04.017
Autor:
Jeffrey N. Strathern, Gustavo Santoyo
Publikováno v:
Microbiological Research. 163:113-119
Hexavalent chromium is known to be a potent carcinogen that leads to many different DNA lesions, including DNA-protein crosslinks, and single- and double-strand breaks. In Saccharomyces cerevisiae, DNA double-strand breaks are mainly repaired by eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c48dbb3d47f6f98964bf4a9218b0d95
https://doi.org/10.1016/j.micres.2007.09.001
https://doi.org/10.1016/j.micres.2007.09.001