Zobrazeno 1 - 10
of 644
pro vyhledávání: '"Jeffrey N, Myers"'
Autor:
Akanksha Srivastava, Graciela M. Nogueras-Gonzalez, Yimin Geng, Jasdev Singh, Jeffrey N. Myers, Yisheng Li, Mark S. Chambers
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 1, Pp 24-40 (2024)
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment; however, their oral toxicity profile is not well elucidated. This review aimed to investigate the prevalence of oral toxicities including xerostomia, mucositis/stomatitis, dysg
Externí odkaz:
https://doaj.org/article/3bbcadf3ffa54ca3a52f5788272ffd2c
Autor:
Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Qi Wang, Ximing Tang, Sen Pathak, Maria Gabriela Raso, Jared K. Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The GOF activities of TP53 mutati
Externí odkaz:
https://doaj.org/article/439599fe4b0841cea0b2d92022192f6d
Autor:
Xinyi Zhang, Frederico O. Gleber‐Netto, Shidan Wang, Roberta Rayra Martins‐Chaves, Ricardo Santiago Gomez, Nadarajah Vigneswaran, Arunangshu Sarkar, William N. William Jr, Vassiliki Papadimitrakopoulou, Michelle Williams, Diana Bell, Doreen Palsgrove, Justin Bishop, John V. Heymach, Ann M. Gillenwater, Jeffrey N. Myers, Renata Ferrarotto, Scott M. Lippman, Curtis Rg Pickering, Guanghua Xiao
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7508-7518 (2023)
Abstract Background Oral leukoplakia (OL) is associated with an increased risk for oral cancer (OC) development. Prediction of OL cancer progression may contribute to decreased OC morbidity and mortality by favoring early intervention. Current OL pro
Externí odkaz:
https://doaj.org/article/f1684d19b6ad4c94aa6119b3cd2b7657
Autor:
Andrew Sikora, Fabio Henrique Brasil da Costa, Abdullah A Osman, Jeffrey N Myers, Roberto Rangel, Alanis Rodriguez Rosario, Nicholas Balbin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/330d78db33e84231ba9e0d0dbc3f7438
Autor:
Bo Yuan, Xi Chen, Wenyi Wang, Ratna Veeramachaneni, Andrew G Sikora, Yewen Shi, Xiaoyong Ren, Shaolong Cao, Fabio Henrique Brasil da Costa, Alanis E Rodriguez Rosario, Arnoldo Corona, Chieko Michikawa, Abdullah A Osman, Tongxin Xie, Jeffrey N Myers, Roberto Rangel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background TP53, the most mutated gene in solid cancers, has a profound impact on most hallmarks of cancer. Somatic TP53 mutations occur in high frequencies in head and neck cancers, including oral squamous cell carcinoma (OSCC). Our study aims to un
Externí odkaz:
https://doaj.org/article/e3736c60fe6045c78cf9a61f33bbf456
Autor:
Yewen Shi, Tongxin Xie, Bingbing Wang, Rong Wang, Yu Cai, Bo Yuan, Frederico O. Gleber-Netto, Xiangjun Tian, Alanis E. Rodriguez-Rosario, Abdullah A. Osman, Jing Wang, Curtis R. Pickering, Xiaoyong Ren, Andrew G. Sikora, Jeffrey N. Myers, Roberto Rangel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Oral squamous cell carcinoma models are presented with defined Trp53 mutations associated with immune checkpoint inhibitor responsiveness, e.g. T122N amino acid change of Tp53 promotes a cold TME enriched with immunosuppressive M2 macrophages resista
Externí odkaz:
https://doaj.org/article/57f97433af1f465f8833d69d49cf18b1
Autor:
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acet
Externí odkaz:
https://doaj.org/article/9e9b057abf944363949c648ff88a38f3
Autor:
Chieko Michikawa, DDS, PhD, Pedro A. Torres-Saavedra, PhD, Natalie L. Silver, MD, MS, Paul M. Harari, MD, Merrill S. Kies, MD, David I. Rosenthal, MD, Quynh-Thu Le, MD, Richard C. Jordan, DDS, PhD, Dzifa Y. Duose, PhD, Saradhi Mallampati, DVM, PhD, Sanchit Trivedi, MS, Rajyalakshmi Luthra, PhD, Ignacio I. Wistuba, MD, Abdullah A. Osman, PhD, Olivier Lichtarge, MD, PhD, Robert L. Foote, MD, Upendra Parvathaneni, MBBS, D. Neil Hayes, MD, MPH, Curtis R. Pickering, PhD, Jeffrey N. Myers, MD, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 6, Pp 100989- (2022)
Purpose: An evolutionary action scoring algorithm (EAp53) based on phylogenetic sequence variations stratifies patients with head and neck squamous cell carcinoma (HNSCC) bearing TP53 missense mutations as high-risk, associated with poor outcomes, or
Externí odkaz:
https://doaj.org/article/af4a399b5e144a18b46cb1524d746ef0
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)
Autor:
Chieko Michikawa, Vancheswaran Gopalakrishnan, Amani M. Harrandah, Tatiana V Karpinets, Rekha Rani Garg, Randy A. Chu, Yuk Pheel Park, Sasanka S. Chukkapallia, Nikhita Yadlapalli, Kelly C. Erikson-Carter, Frederico Omar Gleber-Netto, Elias Sayour, Ann Progulske-Fox, Edward K.L. Chan, Xiaogang Wu, Jianhua Zhang, Christian Jobin, Jennifer A. Wargo, Curtis R. Pickering, Jeffrey N. Myers, Natalie Silver
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100813- (2022)
Recently, increased number of studies have demonstrated a relationship between the oral microbiome and development of head and neck cancer, however, there are few studies to investigate the role of oral bacteria in the context of the tumor microenvir
Externí odkaz:
https://doaj.org/article/974eabb64e8544b885cd3daac2802a36
Autor:
Li Wang, MD, PhD, Piero Fossati, MD, Harald Paganetti, PhD, Li Ma, PhD, Maura Gillison, MD, PhD, Jeffrey N. Myers, MD, PhD, Eugen Hug, MD, Steven J. Frank, MD
Publikováno v:
International Journal of Particle Therapy, Vol 8, Iss 1, Pp 3-13 (2021)
Head and neck squamous cell carcinomas (HNSCCs) often present as local-regionally advanced disease at diagnosis, for which a current standard of care is x-ray–based radiation therapy, with or without chemotherapy. This approach provides effective l
Externí odkaz:
https://doaj.org/article/63a22265bc0541dea3a22b24e0e927a1