Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jeffrey Mcdonald"'
Autor:
Chuanhai Zhang, Mengchen Ye, Kamran Melikov, Dengbao Yang, Goncalo Dias do Vale, Jeffrey McDonald, Kaitlyn Eckert, Mei-Jung Lin, Xing Zeng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Interorganelle contacts facilitate material exchanges and sustain the structural and functional integrity of organelles. Lipid droplets (LDs) of adipocytes are responsible for energy storage and mobilization responding to body needs. LD biog
Externí odkaz:
https://doaj.org/article/25c6a1121dd14ae8ac673d1a12e6a497
Autor:
Zeina Salloum, Kristin Dauner, Yun-feng Li, Neha Verma, David Valdivieso-González, Víctor Almendro-Vedia, John D Zhang, Kiran Nakka, Mei Xi Chen, Jeffrey McDonald, Chase D Corley, Alexander Sorisky, Bao-Liang Song, Iván López-Montero, Jie Luo, Jeffrey F Dilworth, Xiaohui Zha
Publikováno v:
eLife, Vol 13 (2024)
Statins are known to be anti-inflammatory, but the mechanism remains poorly understood. Here, we show that macrophages, either treated with statin in vitro or from statin-treated mice, have reduced cholesterol levels and higher expression of Jmjd3, a
Externí odkaz:
https://doaj.org/article/ed7269abf3734a6fbbad42dc2661c083
Autor:
Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, José Gabriel Barcia Durán, Jeffrey McDonald, Erik R. Nelson, Sunghee Park, Donald P. McDonnell, Kathryn J. Moore, Lily Jun-shen Huang, Edward A. Fisher, Chieko Mineo, Linzhang Huang, Philip W. Shaul
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we show in male mice that hypercho
Externí odkaz:
https://doaj.org/article/acdb55d979ff40c6a879b2daab171d43
Autor:
Brad Padilla, Alan L. Shields, Fiona Taylor, Xiaoran Li, Jeffrey Mcdonald, Tanya Green, Anthony L. Boral, Hui-Min Lin, Cem Akin, Frank Siebenhaar, Brenton Mar
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Indolent systemic mastocytosis (ISM) is a rare, clonal mast cell neoplasm characterized by severe, unpredictable symptoms. The Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) items compose a Total Symptom Score (T
Externí odkaz:
https://doaj.org/article/f99dc0e48e5b4368acd4c26be63b00b4
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100151- (2022)
Lipid transfer proteins acquire and release their lipid cargoes by interacting transiently with source and destination biomembranes. In the GlycoLipid Transfer Protein (GLTP) superfamily, the two-layer all-α-helical GLTP-fold defines proteins that s
Externí odkaz:
https://doaj.org/article/9e1528764da6447b8402017f8db445a2
Autor:
Bret M. Evers, Carlos Rodriguez-Navas, Rachel J. Tesla, Janine Prange-Kiel, Catherine R. Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A. Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L. White, III, Joachim Herz
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2565-2574 (2017)
Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with pr
Externí odkaz:
https://doaj.org/article/a8b5570d8446427886cab7bf1d9791a5
Autor:
Dustin M. Mink, Jeffrey McDonald, Sikha Bagui, William B. Glisson, Jordan Shropshire, Ryan Benton, Samuel Russ
Publikováno v:
Big Data and Cognitive Computing, Vol 5, Iss 2, p 27 (2021)
Modern-day aircraft are flying computer networks, vulnerable to ground station flooding, ghost aircraft injection or flooding, aircraft disappearance, virtual trajectory modifications or false alarm attacks, and aircraft spoofing. This work lays out
Externí odkaz:
https://doaj.org/article/8919bed166a8451483dcacfbfa0608ca
Autor:
Mahesh S. Padanad, Georgia Konstantinidou, Niranjan Venkateswaran, Margherita Melegari, Smita Rindhe, Matthew Mitsche, Chendong Yang, Kimberly Batten, Kenneth E. Huffman, Jingwen Liu, Ximing Tang, Jaime Rodriguez-Canales, Neda Kalhor, Jerry W. Shay, John D. Minna, Jeffrey McDonald, Ignacio I. Wistuba, Ralph J. DeBerardinis, Pier Paolo Scaglioni
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1614-1628 (2016)
KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant
Externí odkaz:
https://doaj.org/article/accd4720f8274f44bb862c81497526a0
Autor:
Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang, Fiona Oh, Jessica Sima, Ruyin Guo, Yun Liu, Chao Zhang, Shaeri Mukherjee, Michael Bassik, Weichun Lin, Huichao Deng, Goncalo Vale, Jeffrey McDonald, Kang Shen, Dengke K. Ma
Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through homeostatic mechanisms conserved in nearly all forms of life. As most eukaryotic enzymes for lipid synthesis and desaturation localize on endoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fcaa1b8edfc016567e5f772ae2d900
https://doi.org/10.1101/2022.08.25.505359
https://doi.org/10.1101/2022.08.25.505359
Autor:
Xing Zeng, Chuanhai Zhang, Goncalo Vale, Kaitlyn Eckert, Jeffrey McDonald, Mei-Jung Lin, Mengchen Ye
Inter-organellar contact sites facilitate material exchanges between membrane-bound intracellular compartments and sustain the structural and functional integrity of organelles1-3. The endoplasmic reticulum (ER)-lipid droplet (LD) contact sites contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01fae6b7d358ad6992de7488dfd05049
https://doi.org/10.21203/rs.3.rs-1290351/v1
https://doi.org/10.21203/rs.3.rs-1290351/v1