Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jeffrey McDermott"'
Autor:
Gladis Sánchez, Gustavo Blanco, Shameem Sultana Syeda, Gunda I. Georg, Kwon Ho Hong, Jeffrey McDermott
Publikováno v:
Biology of Reproduction
One of the mechanisms that cells have developed to fulfil their specialized tasks is to express different molecular variants of a particular protein that has unique functional properties. Na,K-ATPase (NKA), the ion transport mechanism that maintains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce00c9ba2d801047652481a128c5043a
https://doi.org/10.1093/biolre/ioaa093
https://doi.org/10.1093/biolre/ioaa093
Autor:
Lijun Catherine Liu, Amrita Mitra, Gladis Sánchez, Gustavo Blanco, Jeffrey McDermott, September Numata
Publikováno v:
The Journal of membrane biology. 254(5-6)
Mammalian sperm express two Na,K-ATPase (NKA) isoforms, Na,K-ATPase α4 (NKAα4) and Na,K-ATPase α1 (NKAα1). While NKAα4 is critical to sperm motility, the role of NKAα1 in sperm movement remains unknown. We determined this here using a genetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893f540a2816f3edc243c661e3520793
https://pubmed.ncbi.nlm.nih.gov/34129092
https://pubmed.ncbi.nlm.nih.gov/34129092
Autor:
Leandro A. Barbosa, Jessica Venugopal, Gustavo Blanco, Jeffrey McDermott, Gladis Sánchez, Madhulika Sharma, Gail A. Reif, Darren P. Wallace
Publikováno v:
Experimental Cell Research. 355:142-152
The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the ADPKD phenotype includes cell de-differentiation and epithelial to mesenchymal transition (EM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b663bb09f470033dfced0da2c283e3
https://doi.org/10.1016/j.yexcr.2017.04.001
https://doi.org/10.1016/j.yexcr.2017.04.001
Autor:
Jiang Liu, Isabella Mayes, Jeffrey McDermott, Zijian Xie, Sandrine V. Pierre, Gustavo Blanco, Shreya Tapan Mukherji, Luca Brambilla
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfc5dce2d19704d7db67092cfff1bf76
https://doi.org/10.1096/fasebj.2020.34.s1.05852
https://doi.org/10.1096/fasebj.2020.34.s1.05852
Autor:
José A.F.P. Villar, Rosy Iara Maciel de Azambuja Ribeiro, Gustavo Blanco, Jessica M M Valadares, Jeffrey McDermott, Fernando de Pilla Varotti, Cristoforo Scavone, Simone C. Silva, Sayonarah C. Rocha, Leandro A. Barbosa, Marco Túlio C. Pessôa, Gladis Sánchez
Publikováno v:
Steroids
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cardiotonic steroids (CTS) are agents traditionally known for their capacity to bind to the Na,K-ATPase (NKA), affecting the ion transport and the contraction of the heart. Natural CTS have been shown to also have effects on cell signaling pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dcb7778acb2aa4d1f419b916220670
https://doi.org/10.1016/j.steroids.2019.108551
https://doi.org/10.1016/j.steroids.2019.108551
Publikováno v:
Molecular Reproduction and Development. 82:167-181
Most of our knowledge on the biological role of the testis-specific Na,K-ATPase alpha 4 isoform derives from studies performed in non-human species. Here, we studied the function of human Na,K-ATPase alpha 4 after its expression in transgenic mice. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf231a2956a1f99d33a671e1efa5bea
https://doi.org/10.1002/mrd.22454
https://doi.org/10.1002/mrd.22454
Publikováno v:
Journal of Assisted Reproduction and Genetics. 29:1313-1325
Expression of the Na,K-ATPase α4 isoform is required for sperm motility and fertility and is controlled by the Atp1a4 promoter. Here, we have investigated the specific tissue, cell type and developmental regulation of expression mediated by the Atp1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6971294adfda2bbc90cf51588849600
https://doi.org/10.1007/s10815-012-9876-x
https://doi.org/10.1007/s10815-012-9876-x
Autor:
Anh-Nguyet T. Nguyen, Gustavo Blanco, Tamara Jimenez, Gladis Sánchez, Jeffrey McDermott, T. Rajendra Kumar
Publikováno v:
Biology of Reproduction. 84:153-161
The Na,K-ATPase alpha4 (ATP1A4) isoform is specifically expressed in male germ cells and is highly prevalent in spermatozoa. Although selective inhibition of alpha4 activity with ouabain has been shown to affect sperm motility, a more direct analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d315d3b42a90bbc9e902a648724af6ed
https://doi.org/10.1095/biolreprod.110.087064
https://doi.org/10.1095/biolreprod.110.087064
Publikováno v:
Proceedings of the National Academy of Sciences. 108:644-649
Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na + and K +
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d60b18a34ef21c90381a42b1634788
https://doi.org/10.1073/pnas.1016902108
https://doi.org/10.1073/pnas.1016902108
Publikováno v:
Genetics. 178:1371-1383
The larval body wall muscles of Drosophila melanogaster arise by fusion of founder myoblasts (FMs) and fusion-competent myoblasts (FCMs). Sticks-and-Stones (SNS) is expressed on the surface of all FCMs and mediates adhesion with FMs and developing sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85d55c1d101b9eeb344a123db3d8861
https://doi.org/10.1534/genetics.107.083808
https://doi.org/10.1534/genetics.107.083808