Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jeffrey M. Riggs"'
Autor:
Rachel Ettinger, Jodi L. Karnell, Jill Henault, Santosh K. Panda, Jeffrey M. Riggs, Roland Kolbeck, Miguel A. Sanjuan
Publikováno v:
Autoimmunity, Vol 50, Iss 1, Pp 25-36 (2017)
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their r
Externí odkaz:
https://doaj.org/article/ae21a14b0df746ca9389410b806f6814
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Supplementary Table 1Suppl. Table 1 related to materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c867539694432660b7dd69219ed965
https://doi.org/10.1158/2326-6066.22544859.v1
https://doi.org/10.1158/2326-6066.22544859.v1
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Supplementary Figures S1-S7Supplementary Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cee7b46fd70653a2fd06bbbb1e9efe
https://doi.org/10.1158/2326-6066.22544862.v1
https://doi.org/10.1158/2326-6066.22544862.v1
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Checkpoint blockade therapies targeting PD-1/PD-L1 and CTLA-4 are clinically successful but also evoke adverse events due to systemic T-cell activation. We engineered a bispecific, mAb targeting CD28 homolog (CD28H), a newly identified B7 family rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec9ec374bbda9dffe535a040c2c2b71
https://doi.org/10.1158/2326-6066.c.6550767.v1
https://doi.org/10.1158/2326-6066.c.6550767.v1
Autor:
Madhu Ramaswamy, Taeil Kim, Des C. Jones, Hormas Ghadially, Tamer I. Mahmoud, Andrew Garcia, Gareth Browne, Zenon Zenonos, Yvonne Puplampu-Dove, Jeffrey M. Riggs, Geetha K. Bhat, Ronald Herbst, Darren J. Schofield, Gianluca Carlesso
Publikováno v:
Cancer immunology research. 10(2)
Checkpoint blockade therapies targeting PD-1/PD-L1 and CTLA-4 are clinically successful but also evoke adverse events due to systemic T-cell activation. We engineered a bispecific, mAb targeting CD28 homolog (CD28H), a newly identified B7 family rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c36032091d7d1ccc89453eacc2b535
https://pubmed.ncbi.nlm.nih.gov/34937728
https://pubmed.ncbi.nlm.nih.gov/34937728
Autor:
Jodi L. Karnell, Michael A Smith, William Rees, Victoria P. Werth, Jill Henault, Li Yan, Katherine Ann Vousden, Jeffrey M. Riggs, Miguel A. Sanjuan, Vib Trial Investigators, G. Illei, John N. Ratchford, Yanping Wu, Simone M. Nicholson, Kerry A. Casey, Nanette Mittereder, Michele Gunsior, Jorn Drappa
Publikováno v:
Science translational medicine. 13(595)
Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive immune responses through expression of additional proinflammatory cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f756505d859805fbcc4dee9f1bc05b48
https://pubmed.ncbi.nlm.nih.gov/34039741
https://pubmed.ncbi.nlm.nih.gov/34039741
Autor:
Dominic Sinibaldi, Ethan Grant, Rachel Ettinger, Melissa Parker, Michael A Smith, Kerry A. Casey, Michelle Petri, Devon K. Taylor, Miguel A. Sanjuan, Jodi L. Karnell, Jill Henault, Jeffrey M. Riggs, Roland Kolbeck
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Systemic lupus erythematosus (SLE) impacts multiple organ systems, although the causes of many individual SLE pathologies are poorly understood. This study was designed to elucidate organ-specific inflammation by identifying proteins that correlate w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432b694e2e9988008e2291098b4c8488
https://doi.org/10.1038/s41598-019-50231-y
https://doi.org/10.1038/s41598-019-50231-y
Autor:
Desmond Jones, Tamer Mahmoud, Madhu Ramaswamy, Susan Wilson, Gianluca Carlesso, Jeffrey M. Riggs, Andrew Garcia, Hormas Ghadially, Darren J. Schofield, Taeil Kim
Publikováno v:
Cancer Research. 80:4438-4438
The success of immune checkpoint inhibitors CTLA4 and PD-1 monoclonal antibody, both FDA approved cancer therapies, specifically counteracts inhibitory pathways to activate antigen-specific T cells. However, their success is limited by the fact that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe0bc1a536d2aa728836f64ad1978bc
https://doi.org/10.1158/1538-7445.am2020-4438
https://doi.org/10.1158/1538-7445.am2020-4438
Autor:
Jill Henault, Roland Kolbeck, Santosh K. Panda, Jeffrey M. Riggs, Rachel Ettinger, Jodi L. Karnell, Miguel A. Sanjuan
Publikováno v:
Autoimmunity. 50(1)
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9549c2b96cb270f3a6a4c8aa76d453f4
https://pubmed.ncbi.nlm.nih.gov/28166684
https://pubmed.ncbi.nlm.nih.gov/28166684
Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model
Autor:
William Vermi, Miguel A. Sanjuan, Sarah L. Rowland, Jeffrey M. Riggs, Susan Gilfillan, Emil R. Unanue, Roland Kolbeck, Marco Colonna, Mattia Bugatti
Publikováno v:
Journal of Experimental Medicine. 211:1977-1991
Plasmacytoid dendritic cells (pDCs) have long been implicated in the pathogenesis of lupus. However, this conclusion has been largely based on a correlative link between the copious production of IFN-α/β by pDCs and the IFN-α/β “signature” of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7731afdfc026c4942a7f965d1bc7b96
https://doi.org/10.1084/jem.20132620
https://doi.org/10.1084/jem.20132620