Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Jeffrey M. Peters"'
Autor:
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters
Externí odkaz:
https://doaj.org/article/a855de1025a445adaa26ec6581764497
Autor:
Robert G. Nichols, Bipin Rimal, Fuhua Hao, Jeffrey M. Peters, Emily R. Davenport, Andrew D. Patterson
Publikováno v:
Environment International, Vol 192, Iss , Pp 109022- (2024)
The organophosphate chlorpyrifos is a commonly used pesticide for fruits and vegetables despite its association with neurotoxicity in humans. While some studies suggest that organophosphates may impact the gut microbiota, no studies to date have inve
Externí odkaz:
https://doaj.org/article/99b50383e8e6472790e6e98410c29910
Autor:
Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 606 (2024)
Nuclear hormone receptors exist in dynamic equilibrium between transcriptionally active and inactive complexes dependent on interactions with ligands, proteins, and chromatin. The present studies examined the hypothesis that endogenous ligands activa
Externí odkaz:
https://doaj.org/article/231cd6ff406947e89aa731b290f06494
Autor:
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Publikováno v:
Metabolites, Vol 13, Iss 8, p 936 (2023)
Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both Ppara-null and PPARA-humanized mice, yet both lines develop age-related
Externí odkaz:
https://doaj.org/article/1049ad43d5d041adbdc3b51a8f7b2f5d
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-10 (2019)
Abstract The human microbiome is composed of four major areas including intestinal, skin, vaginal, and oral microbiomes, with each area containing unique species and unique functionalities. The human microbiome may be modulated with prebiotics, probi
Externí odkaz:
https://doaj.org/article/2489f8ac5a914535bfe665dc7696d75b
Autor:
Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae-Il Choi, Ji-Min Yang, Ju-Young Kim, Young-Chan Kim, Hyun-Jai Cho, Jeffrey M. Peters, Seung-Bum Ryoo, Young Tae Kim, Hyo-Soo Kim
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1614-1625 (2015)
We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells in vitro and in vivo. Myeloid cell-specific knockout of PPARβ/δ results in imp
Externí odkaz:
https://doaj.org/article/54ff192ba67047f48eb2b24391cc4f82
Autor:
David A. Pan, Michelle K. Mater, Annette P. Thelen, Jeffrey M. Peters, Frank J. Gonzalez, Donald B. Jump
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 5, Pp 742-751 (2000)
The glycolytic enzyme, L-pyruvate kinase (L-PK), plays an important role in hepatic glucose metabolism. Insulin and glucose induce L-PK gene expression, while glucagon and polyunsaturated fatty acids (PUFA) inhibit L-PK gene expression. We have been
Externí odkaz:
https://doaj.org/article/1a16505d17984b7b8035535958359176
Autor:
Mary C. Hunt, Per J.G. Lindquist, Jeffrey M. Peters, Frank J. Gonzalez, Ulf Diczfalusy, Stefan E.H. Alexson
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 5, Pp 814-823 (2000)
Long-chain acyl-CoA thioesterases catalyze the hydrolysis of acyl-CoAs to the corresponding free fatty acid and CoA. We recently cloned four members of a novel multigene family of peroxisome proliferator-induced genes encoding cytosolic (CTE-I), mito
Externí odkaz:
https://doaj.org/article/a28da9531d8844a495d928be33cff36a
Publikováno v:
PPAR Research, Vol 2008 (2008)
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeosta
Externí odkaz:
https://doaj.org/article/1a0c22c3fed0489690919c2f4584f391
Autor:
Lakshmi Gopinathan, Daniel B. Hannon, Russell W. Smith, Jeffrey M. Peters, John P. Vanden Heuvel
Publikováno v:
PPAR Research, Vol 2008 (2008)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors and of interest are cofactors with ubiquitin ligas
Externí odkaz:
https://doaj.org/article/3e991e6a7f5d4d198926e6c3c15b715e