Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffrey M. Partridge"'
Autor:
Hanson Gunnar J, Philip F. Hughes, Barta Thomas E, Amy F. Barabasz, Briana Foley, James Marvin Veal, Jeffrey M. Partridge, Christopher John Markworth, Andy J. Ommen, Melanie Silinski, Steven E. Hall, John W. Rice, Paul M. Steed, Emilie D. Smith, Patrick Fadden, Kenneth He Huang, Wei Ma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2550-2554
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. These aminoquinazoline derivatives, represented by compound 15 (SNX-683
Autor:
James Marvin Veal, Amy F. Barabasz, Jeffrey M. Partridge, Kenneth He Huang, John W. Rice, Melanie Silinski, Steven E. Hall, Barta Thomas E, Laura G. Dubois, Paul M. Steed, Patrick Fadden, Sarah R. Mabbett
Publikováno v:
Arthritis & Rheumatism. 58:3765-3775
Objective. To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. A close analog was evaluated in preclini
Autor:
Jeffrey M. Partridge, Laura A. Koutsky
Publikováno v:
The Lancet Infectious Diseases. 6:21-31
Genital human papillomavirus (HPV) infection, globally one of the most common sexually transmitted infections, is associated with cancers, genital warts, and other epithelial lesions. Although a consistent and coherent picture of the epidemiology and
Autor:
Phu Dac, Tran, Long Ngoc, Vu, Hien Tran, Nguyen, Lan Trong, Phan, Wayne, Lowe, Michelle S, McConnell, Michael F, Iademarco, Jeffrey M, Partridge, James C, Kile, Trang, Do, Patrick J, Nadol, Hien, Bui, Diep, Vu, Kyle, Bond, David B, Nelson, Lauren, Anderson, Kenneth V, Hunt, Nicole, Smith, Paul, Giannone, John, Klena, Denise, Beauvais, Kristi, Becknell, Jordan W, Tappero, Scott F, Dowell, Peter, Rzeszotarski, May, Chu, Carl, Kinkade
Publikováno v:
MMWR. Morbidity and Mortality Weekly Report
Over the past decade, Vietnam has successfully responded to global health security (GHS) challenges, including domestic elimination of severe acute respiratory syndrome (SARS) and rapid public health responses to human infections with influenza A(H5N
Publikováno v:
Journal of Biological Chemistry. 273:24396-24405
Microcystin-affinity chromatography was used to purify 15 protein phosphatase 1 (PP1)-binding proteins from the myofibrillar fraction of rabbit skeletal muscle. To reduce the time and amount of material required to identify these proteins, proteome a
Autor:
Jeron Eaves, Meredith Lewis, Steven E. Hall, Amy F. Barabasz, Mei Hu, Andy J. Ommen, James Marvin Veal, Barta Thomas E, James C. Otto, Matthew Jenks, Bert Pronk, Jeffrey M. Partridge, John W. Rice, Melanie Silinski, Katleen Verleysen, Lindsay Hinkley, Jon-Paul Strachan, Briana Foley, Angela R. Woodward, Geng Lifeng, Anisa Scott, Emilie D. Smith, Wei Ma, Paul M. Steed, Tiffany Freed, Laura G. Dubois, W. Stephen Mccall, Hanson Gunnar J, Philip F. Hughes, Patrick Fadden, Kenneth He Huang, Christopher John Markworth
Publikováno v:
Journal of medicinal chemistry. 52(14)
A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library. These indol-4-one and indazol-4-one derived 2-aminobenzamides showed strong binding affinity t
Autor:
Geng Lifeng, James Marvin Veal, Jeffrey M. Partridge, Amy F. Barabasz, Steven E. Hall, James C. Otto, Barta Thomas E, Hanson Gunnar J, John W. Rice, Matthew Jenks, Wei Ma, Briana Foley, Patrick Fadden, Kenneth He Huang
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(12)
Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the discovery of a novel small molecule scaffold that inhibits Hsp90. X-ray data show that the sc
Autor:
James P. Hughes, Michael Stern, Long Fu Xi, Rachel L. Winer, Stephen E. Hawes, Jeffrey M. Partridge, Nancy B. Kiviat, Qinghua Feng, Laura A. Koutsky, Sandra O'Reilly, Bethany A. Weaver, Shu Kuang Lee
Publikováno v:
The Journal of infectious diseases. 196(8)
In contrast to the wealth of data on human papillomavirus (HPV) infections in women, much less is known about HPV in men.Between June 2003 and March 2006, a total of 240 heterosexually active male university students 18-20 years of age were recruited
Autor:
Briana Foley, Wei Ma, Steven E. Hall, Emilie D. Smith, Gijsbertus J. Pronk, Jeron Eaves, Laura G. Dubois, James Marvin Veal, Mei Hu, Amy F. Barabasz, James C. Otto, Timothy A.J. Haystead, Katleen Verleysen, Barta Thomas E, Matthew Jenks, Paul M. Steed, Hanson Gunnar J, Philip F. Hughes, Lindsay Hinkley, Tiffany Freed, Patrick Fadden, John W. Rice, Anisa Scott, Jeffrey M. Partridge, Angela Woodward Spangenberg, Kenneth He Huang, Melanie Silinski, Andy J. Ommen, Meredith Lewis
Publikováno v:
Chemistry & Biology. (7):686-694
SummaryA chemoproteomics-based drug discovery strategy is presented that utilizes a highly parallel screening platform, encompassing more than 1000 targets, with a focused chemical library prior to target selection. This chemoproteomics-based process