Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jeffrey M. McManus"'
Autor:
Mehdi Baratchian, Jeffrey M. McManus, Mike P. Berk, Fumihiko Nakamura, Sanjay Mukhopadhyay, Weiling Xu, Serpil Erzurum, Judy Drazba, John Peterson, Eric A. Klein, Benjamin Gaston, Nima Sharifi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonar
Externí odkaz:
https://doaj.org/article/6ebf2e7f44a9410abac21588fc2e74c2
Publikováno v:
Eur J Endocrinol
Context A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression neither for viral susceptib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b791d9666c717dbc9dcbfad1ff7136
https://doi.org/10.1530/eje-21-0996
https://doi.org/10.1530/eje-21-0996
Publikováno v:
JNCI cancer spectrum. 6(5)
Background The germline variant rs1047303 (HSD3B1[1245A/C]), restricting or enabling production of potent androgens and estrogens from adrenal precursors, affects outcomes of castration-resistant prostate cancer and is associated with estrogen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174cbe784bfeef94746fd7e050b2f98c
https://pubmed.ncbi.nlm.nih.gov/35947687
https://pubmed.ncbi.nlm.nih.gov/35947687
Autor:
Fumihiko Nakamura, Sanjay Mukhopadhyay, Mehdi Baratchian, Judy Drazba, Nima Sharifi, Serpil C. Erzurum, Weiling Xu, Jeffrey M. McManus, John W. Peterson, Benjamin Gaston, Eric A. Klein, Mike Berk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98771f3d263fded475c727bb11027dc
https://doaj.org/article/6ebf2e7f44a9410abac21588fc2e74c2
https://doaj.org/article/6ebf2e7f44a9410abac21588fc2e74c2
Publikováno v:
Journal of the Endocrine Society. 6(5)
A growing body of evidence suggests a role for androgens in asthma and asthma control. This includes a sex discordance in disease rates that changes with puberty, experiments in mice showing androgens reduce airway inflammation, and a reported associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b199305e907937d41d832b135b2cb3
https://pubmed.ncbi.nlm.nih.gov/35402761
https://pubmed.ncbi.nlm.nih.gov/35402761
Autor:
Stanley L. Hazen, Nima Sharifi, Fumihiko Nakamura, Mona Patel, Xiuxiu Li, Erinn Downs, Yoon-Mi Chung, Peter Bazeley, Aaron C Bernstein, Sarat Chandarlapaty, Aimalie Hardaway, Halle C. F. Moore, Wei Wei, Serena Nik-Zainal, George Thomas Budd, Jeffrey M. McManus, Jame Abraham, Mathew Thomas, Megan L. Kruse, W.H. Wilson Tang
Publikováno v:
JCI Insight
BACKGROUND Genetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b74aa8ecbc9d2b2f50a6cf5fda092b7
https://doi.org/10.1172/jci.insight.150403
https://doi.org/10.1172/jci.insight.150403
Publikováno v:
Learning & Memory. 26:151-165
Sensory feedback shapes ongoing behavior and may produce learning and memory. Motor responses to edible or inedible food in a reduced Aplysia preparation were examined to test how sensory feedback affects behavior and memory. Feeding patterns were in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81823a17218f2922f3fef3cebf962a83
https://doi.org/10.1101/lm.048983.118
https://doi.org/10.1101/lm.048983.118
Publikováno v:
Cancer Research. 82:647-647
Breast and endometrial cancer are both malignancies that can be classified into subtypes based on their hormone dependence, such as estrogen receptor (ER)-positive vs. ER-negative breast cancer and low-grade vs. high-grade endometrial cancer. The gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d84e58c6b72bdb70d7e6a3f3eca8c8a
https://doi.org/10.1158/1538-7445.am2022-647
https://doi.org/10.1158/1538-7445.am2022-647
Publikováno v:
Endocr Rev
Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone deprivation in the 1940s and therefore firmly established the concept that prostate cancer is a highly androgen-dependent disease. Since that time, hormonal therapy has un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805777f07006be7e3ecf714cd8b16a6a
https://pubmed.ncbi.nlm.nih.gov/33480983
https://pubmed.ncbi.nlm.nih.gov/33480983
Autor:
John W. Peterson, Mehdi Baratchian, Fumihiko Nakamura, Serpil C. Erzurum, M. Berk, Nima Sharifi, Sanjay Mukhopadhyay, Gaston Ben, Jeffrey M. McManus, Eric A. Klein, Weiling Xu, Judy Drazba
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
Scientific Reports
article-version (status) pre
article-version (number) 2
Scientific Reports
The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ab44b082e2f9479b51947fb745c114
http://europepmc.org/articles/PMC7574256
http://europepmc.org/articles/PMC7574256