Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jeffrey M. McManus"'
Autor:
Mehdi Baratchian, Jeffrey M. McManus, Mike P. Berk, Fumihiko Nakamura, Sanjay Mukhopadhyay, Weiling Xu, Serpil Erzurum, Judy Drazba, John Peterson, Eric A. Klein, Benjamin Gaston, Nima Sharifi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonar
Externí odkaz:
https://doaj.org/article/6ebf2e7f44a9410abac21588fc2e74c2
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224081 (2019)
Steroid hormones and their respective nuclear receptors are essential mediators in numerous physiologic and pathophysiologic processes, ranging from regulation of metabolism, immune function, and reproductive processes to the development of hormone-d
Externí odkaz:
https://doaj.org/article/fc38b79f00c646ed98ab7326ac3146d8
Publikováno v:
Eur J Endocrinol
Context A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression neither for viral susceptib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b791d9666c717dbc9dcbfad1ff7136
https://doi.org/10.1530/eje-21-0996
https://doi.org/10.1530/eje-21-0996
Publikováno v:
JNCI cancer spectrum. 6(5)
Background The germline variant rs1047303 (HSD3B1[1245A/C]), restricting or enabling production of potent androgens and estrogens from adrenal precursors, affects outcomes of castration-resistant prostate cancer and is associated with estrogen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174cbe784bfeef94746fd7e050b2f98c
https://pubmed.ncbi.nlm.nih.gov/35947687
https://pubmed.ncbi.nlm.nih.gov/35947687
Autor:
Fumihiko Nakamura, Sanjay Mukhopadhyay, Mehdi Baratchian, Judy Drazba, Nima Sharifi, Serpil C. Erzurum, Weiling Xu, Jeffrey M. McManus, John W. Peterson, Benjamin Gaston, Eric A. Klein, Mike Berk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98771f3d263fded475c727bb11027dc
https://doaj.org/article/6ebf2e7f44a9410abac21588fc2e74c2
https://doaj.org/article/6ebf2e7f44a9410abac21588fc2e74c2
Publikováno v:
Cancer Research. 82:647-647
Breast and endometrial cancer are both malignancies that can be classified into subtypes based on their hormone dependence, such as estrogen receptor (ER)-positive vs. ER-negative breast cancer and low-grade vs. high-grade endometrial cancer. The gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d84e58c6b72bdb70d7e6a3f3eca8c8a
https://doi.org/10.1158/1538-7445.am2022-647
https://doi.org/10.1158/1538-7445.am2022-647
Publikováno v:
Journal of the Endocrine Society. 6(5)
A growing body of evidence suggests a role for androgens in asthma and asthma control. This includes a sex discordance in disease rates that changes with puberty, experiments in mice showing androgens reduce airway inflammation, and a reported associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b199305e907937d41d832b135b2cb3
https://pubmed.ncbi.nlm.nih.gov/35402761
https://pubmed.ncbi.nlm.nih.gov/35402761
Autor:
Stanley L. Hazen, Nima Sharifi, Fumihiko Nakamura, Mona Patel, Xiuxiu Li, Erinn Downs, Yoon-Mi Chung, Peter Bazeley, Aaron C Bernstein, Sarat Chandarlapaty, Aimalie Hardaway, Halle C. F. Moore, Wei Wei, Serena Nik-Zainal, George Thomas Budd, Jeffrey M. McManus, Jame Abraham, Mathew Thomas, Megan L. Kruse, W.H. Wilson Tang
Publikováno v:
JCI Insight
BACKGROUND Genetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b74aa8ecbc9d2b2f50a6cf5fda092b7
https://doi.org/10.1172/jci.insight.150403
https://doi.org/10.1172/jci.insight.150403
Publikováno v:
Learning & Memory. 26:151-165
Sensory feedback shapes ongoing behavior and may produce learning and memory. Motor responses to edible or inedible food in a reduced Aplysia preparation were examined to test how sensory feedback affects behavior and memory. Feeding patterns were in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81823a17218f2922f3fef3cebf962a83
https://doi.org/10.1101/lm.048983.118
https://doi.org/10.1101/lm.048983.118
Publikováno v:
Endocr Rev
Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone deprivation in the 1940s and therefore firmly established the concept that prostate cancer is a highly androgen-dependent disease. Since that time, hormonal therapy has un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805777f07006be7e3ecf714cd8b16a6a
https://pubmed.ncbi.nlm.nih.gov/33480983
https://pubmed.ncbi.nlm.nih.gov/33480983