Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeffrey M. McKenna"'
Publikováno v:
CHIMIA, Vol 77, Iss 7/8 (2023)
Externí odkaz:
https://doaj.org/article/f1a86ec7ed6642fda0e44a3ba89a38e4
Autor:
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O. Frank, Matthew J. Hesse, Daniela Dankova, Jae-Geun Song, Megan Bruce-Smythe, Heidi Struble, Francisco J. Garcia, Scott M. Brittain, Andrew C. Kile, Lynn M. McGregor, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1702-1702 (2023)
Externí odkaz:
https://doaj.org/article/45f60932a33347c4abe0263c84aaeafc
Autor:
Kelsey E. Sivick, Anthony L. Desbien, Laura Hix Glickman, Gabrielle L. Reiner, Leticia Corrales, Natalie H. Surh, Thomas E. Hudson, Uyen T. Vu, Brian J. Francica, Tamara Banda, George E. Katibah, David B. Kanne, Justin J. Leong, Ken Metchette, Jacob R. Bruml, Chudi O. Ndubaku, Jeffrey M. McKenna, Yan Feng, Lianxing Zheng, Steven L. Bender, Charles Y. Cho, Meredith L. Leong, Andrea van Elsas, Thomas W. Dubensky, Jr., Sarah M. McWhirter
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3074-3085.e5 (2018)
Summary: Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is us
Externí odkaz:
https://doaj.org/article/6640eed869a2425eb7c9442fb0d88d76
Autor:
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O. Frank, Matthew J. Hesse, Daniela Dankova, Jae-Geun Song, Megan Bruce-Smythe, Heidi Struble, Francisco J. Garcia, Scott M. Brittain, Andrew C. Kile, Lynn M. McGregor, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Publikováno v:
ACS Central Science. 9:915-926
Autor:
Angel Gonzalez-Valero, Audrey G. Reeves, Annika C. S. Page, Patrick J. Moon, Edward Miller, Katia Coulonval, Steven W. M. Crossley, Xiao Xie, Dan He, Patricia Z. Musacchio, Alec H. Christian, Jeffrey M. McKenna, Richard A. Lewis, Eric Fang, Dustin Dovala, Yipin Lu, Lynn M. McGregor, Markus Schirle, John A. Tallarico, Pierre P. Roger, F. Dean Toste, Christopher J. Chang
Publikováno v:
J Am Chem Soc
Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing functional protein sites and compounds for therapeutic development. However, the vast majority of ABPP methods for covalent drug discovery target highl
Publikováno v:
Synthesis. 55:837-845
A one step electrophilic fluorination of alkenes is reported, which furnishes the products in a highly regioselective manner via allylic rearrangement. The reaction proceeds efficiently under mild conditions with the use of trisubstituted alkenes as
Autor:
Patrick Moon, Charlotte M. Zammit, Qian Shao, Dustin Dovala, Lydia Boike, Nathaniel J. Henning, Mark Knapp, Jessica N. Spradlin, Carl C. Ward, Helene Wolleb, Daniel Fuller, Gabrielle Blake, Jason P. Murphy, Feng Wang, Yipin Lu, Stephanie A. Moquin, Laura Tandeske, Matthew J. Hesse, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, F. Dean Toste, Daniel K. Nomura
Publikováno v:
ChemBioChem.
Autor:
Flor A. Gowans, Danny Q. Thach, Yangzhi Wang, Belen E. Altamirano Poblano, Dustin Dovala, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura
SummaryOphiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the proteome-wide targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18cdbfe8d02ec6a1bd7812b67f98c4a
https://doi.org/10.1101/2023.03.09.531918
https://doi.org/10.1101/2023.03.09.531918
Autor:
Annika C. S. Page, Spencer O. Scholz, Katherine N. Keenan, Jessica N. Spradlin, Bridget P. Belcher, Scott M. Brittain, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Daniel K. Nomura, F. Dean Toste
Publikováno v:
Chemical science, vol 13, iss 13
Photoaffinity labeling (PAL) is a powerful tool for the identification of non-covalent small molecule-protein interactions that are critical to drug discovery and medicinal chemistry, but this approach is limited to only a small subset of robust phot
Autor:
Nafsika Forte, Dustin Dovala, Matthew J. Hesse, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Targeted protein degradation (TPD) with Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds consisting of protein targeting ligands linked to recruiters of E3 ubiquitin ligases, has arisen as a powerful therapeutic modality to indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec8dd8ee0ad57c401128e4c23f1b503
https://doi.org/10.1101/2022.12.19.520812
https://doi.org/10.1101/2022.12.19.520812