Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeffrey M. Howell"'
Publikováno v:
Tetrahedron: Asymmetry. 14:3673-3677
The chiral intermediate (3R)-cis-3-acetyloxy-4-(1,1-dimethylethyl)-2-azetidinone 2 was prepared for the semi-synthesis of the new taxane 5, an orally active anticancer compound. The enantioselective enzymatic hydrolysis of cis-3-acetyloxy-4-(1,1-dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac9f83985d2a33781cb42a3bd2492e6
https://doi.org/10.1016/j.tetasy.2003.09.019
https://doi.org/10.1016/j.tetasy.2003.09.019
Autor:
Robert J. Johnston, Ramesh N. Patel, Ronald L. Hanson, Jeffrey M. Howell, Amit Banerjee, Rapheal Ko, Mary-Jo Donovan, Animesh Goswami, Dana L Cazzulino, Steven L. Goldberg, David B. Brzozowski, Venkata B. Nanduri, Thomas P. Tully
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 30:252-259
There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158b016c82fa7a54dbd6b58c49980d87
https://doi.org/10.1007/s10295-003-0032-6
https://doi.org/10.1007/s10295-003-0032-6
Autor:
Jeffrey M. Howell, Maxime Soumeillant, K. David Mirfakhrae, Truc Chi Vu, and David R. Kronenthal, Shankar Swaminathan, Xinhua Qian, Xuebao Wang, Edward Y. Hua, Bin Zheng, Animesh Goswami, Fernando Quiroz, Ramesh N. Patel
Publikováno v:
Organic Process Research & Development. 5:415-420
(S)-N-(tert-Butoxycarbonyl)-3-hydroxymethylpiperidine 1 was made from (R,S)-3-hydroxymethylpiperidine 2 via fractional crystallization of the corresponding l(−)-dibenzoyl tartarate salt 3 followed by hydrolysis and acylation. Lipase from Pseudomona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ae393408f263983d9ea4010098954f
https://doi.org/10.1021/op010210b
https://doi.org/10.1021/op010210b
Autor:
Jeffrey M. Howell, David B. Brzozowski, Ronald F Eiring, R. N. Patel, Venkata B. Nanduri, Abhisek Banerjee
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 25:171-175
The 2-ketoreductase from Gluconobacter oxydans (SC 13851) catalyzes the reduction of 2-pentanone to (S)-(+)-2-pentanol. The 2-ketoreductase was purified 295-fold to homogeneity from G. oxydans cell extracts. The purified 2-ketoreductase had a molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04ccf474a6c337fd36b5565aada2716
https://doi.org/10.1038/sj.jim.7000047
https://doi.org/10.1038/sj.jim.7000047
Autor:
Bang-Chi Chen, Andrew Rusowicz, Ronald F Eiring, Francis J. Okuniewicz, Valerie Zannella, Kenneth J. Natalie, Shawn K. Pack, Ramesh N. Patel, Steven R. Schwarz, Kai S Tse, John J. Venit, Susan C Durand, John M. Wasylyk, Bruce T Lotz, Keith Ramig, Ronald L. Hanson, John C. Harris, William L. Parker, Shankar Swaminathan, Victor W. Rosso, David A. Lust, Mary Jo Donovan, Laszlo J. Szarka, Mark Liu, Laporte Thomas L, Michael A. Montana, Dana L Cazzulino, Venkata B. Nanduri, Peter J. Bernot, Jeffrey M. Howell
Publikováno v:
Enzyme and Microbial Technology. 26:348-358
Allysine ethylene acetal [(S)-2-amino-5-(1,3-dioxolan-2-yl)-pentanoic acid (2)] was prepared from the corresponding keto acid by reductive amination using phenylalanine dehydrogenase (PDH) from Thermoactinomyces intermedius ATCC 33205. Glutamate, ala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a09021bd4305ecd5ef317f78de9a3
https://doi.org/10.1016/s0141-0229(99)00175-1
https://doi.org/10.1016/s0141-0229(99)00175-1
Autor:
Clyde G. McNamee, David R. Kronenthal, Ramesh N. Patel, Jeffrey T. North, Amit Banerjee, Jeffrey M. Howell, Laszlo J. Szarka, Brian L. Davis, David Brzozowaski
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:535-542
The chiral intermediate (3 S ,4 R )- trans -3,4-dihydro-3,4-dihydroxy-2,2-dimethyl-2 H -1-benzopyran-6-carbonitrile [(+)- trans diol 3 ] was made by the stereoselective microbial epoxidation of 2,2-dimethyl-2 H -1-benzopyran-6-carbonitrile 1 . This c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080ca9082730c9097bb727b63b36d3ec
https://doi.org/10.1016/0968-0896(94)80024-3
https://doi.org/10.1016/0968-0896(94)80024-3
Autor:
Venkat Nanduri, David Brozozowski, Jeffrey M. Howell, Clyde G. McNamee, Ramesh N. Patel, David Mirfakhrae, Laszlo J. Szarka, John K. Thottathil, Amit Banerjee
Publikováno v:
Tetrahedron: Asymmetry. 4:2069-2084
The chiral intermediate (2R,3S)-(−)-N-benzoyl-3-phenyl isoserine ethyl ester 2a , a potential taxol 5 side-chain synthon, was prepared by microbial and enzymatic processes. Taxol 5 is an anticancer compound recently approved by FDA for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250361397d7a33dc2664c61070829215
https://doi.org/10.1016/s0957-4166(00)82256-9
https://doi.org/10.1016/s0957-4166(00)82256-9
Autor:
David Mirfakhrae, Jeffrey M. Howell, Amit Banerjee, Laszlo J. Szarka, Clyde G. McNamee, David Brozozowski, John K. Thottathil, Venkat Nanduri, Ramesh N. Patel
Publikováno v:
ChemInform. 25
The chiral intermediate (2R,3S)-(−)-N-benzoyl-3-phenyl isoserine ethyl ester 2a , a potential taxol 5 side-chain synthon, was prepared by microbial and enzymatic processes. Taxol 5 is an anticancer compound recently approved by FDA for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37de42c69fab528ea4eb9bc7d22aa980
https://doi.org/10.1002/chin.199402060
https://doi.org/10.1002/chin.199402060
Publikováno v:
Annals of the New York Academy of Sciences. 672:415-424
A key intermediate, S-(−)-3-benzoylthio-2-methylpropanoic acid (1) was made in high optical purity by the lipase-catalyzed stereoselective esterification of racemic 1 with methanol in an organic solvent system. Among various lipases evaluated, Aman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0637157595d2dc5a307667ba81f73dce
https://doi.org/10.1111/j.1749-6632.1992.tb35651.x
https://doi.org/10.1111/j.1749-6632.1992.tb35651.x
Autor:
Jeffrey M. Howell, Amit Banerjee, Ramesh N. Patel, Laszlo J. Szarka, Robert S. Robison, Clyde G. McNamee
Publikováno v:
Enzyme and Microbial Technology. 14:731-738
A key chiral intermediate S (−)-4-chloro-3-hydroxybutanoic acid, methyl ester 2 was made in high optical purity by the stereoselective reduction of 4-chloro-3-oxobutanoic acid methyl ester 1 by cell suspensions of Geotrichum candidum SC 5469. A rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12cb1bea873e920893eaab35f93125a8
https://doi.org/10.1016/0141-0229(92)90113-3
https://doi.org/10.1016/0141-0229(92)90113-3