Výsledky vyhledávání - "Jeffrey M. Harrington"

Akademický článek

Suaugusiųjų švietimo praktika postmoderniame pasaulyje

Autor: Jeffrey M. Harrington

Publikováno v: Acta Paedagogica Vilnensia, Vol 13, Iss 13 (2016)

Straipsnyje nagrinėjama itin aktuali suaugusiųjų švietimo problema. Autorius kelia klausimus: kokia suaugusiųjų švietimo vieta šiandienėje edukologijoje ir kokį vaidmenį suaugusiųjų mokymasis visą gyvenimą atlieka postmoderniame pasaul

Externí odkaz: https://doaj.org/article/b7fbdb26d96e4583a25ab3b37f4f0f83

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EP3 signaling is decoupled from regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance

Autor: Michelle E. Kimple, Matthew J. Merrins, Jeffrey M. Harrington, Sophia M. Sdao, Grant M. Kelly, Michael D. Schaid

Of the β-cell signaling pathways altered by non-diabetic obesity and insulin resistance, some are adaptive while others actively contribute to β-cell failure and demise. Cytoplasmic calcium (Ca2+) and cyclic AMP (cAMP), which control the timing and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6625b5fd5e81d2c3606cb83d96687a
https://doi.org/10.1101/2020.07.10.197863

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Differential Effects of Prostaglandin E2 Production and Signaling through the Prostaglandin EP3 Receptor on Human Beta-cell Compensation

Autor: Nathan A. Truchan, Buchanan R, Austin Reuter, Harpreet K Sandhu, Rachel J. Fenske, Michelle E. Kimple, Jeffrey M. Harrington, Moeller J

ObjectiveSignaling through Prostaglandin E3 Receptor (EP3), a G protein-coupled receptor for E series prostaglandins such as prostaglandin E2(PGE2), has been linked to the beta-cell dysfunction and loss of beta-cell mass in type 2 diabetes (T2D). In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d5df1b5668095b178d7356a6e3122

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Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

Autor: Grant M. Kelly, Kathryn A. Carbajal, Dudley W. Lamming, Michelle E. Kimple, Erin Guthery, Shannon J. Gallagher, Allison L. Brill, Joshua C. Neuman, Darby C. Peter, Cara L Green, Molly L. Wehner, Michael D. Schaid, Austin Reuter, Jeffrey M. Harrington

Publikováno v: The Journal of Biological Chemistry

The inhibitory G protein alpha-subunit (Gαz) is an important modulator of beta-cell function. Full-body Gαz-null mice are protected from hyperglycemia and glucose intolerance after long-term high-fat diet (HFD) feeding. In this study, at a time poi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d299e7f361025fcb5f8c430f86202b
https://doi.org/10.1074/jbc.ra120.015585

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